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中华移植杂志(电子版) ›› 2017, Vol. 11 ›› Issue (03) : 138 -142. doi: 10.3877/cma.j.issn.1674-3903.2017.03.003

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述评

胰岛移植治疗1型糖尿病的进展与挑战
黄孝伦1,()   
  1. 1. 610072 成都,电子科技大学医学院附属医院(四川省人民医院)肝胆胰外科中心 细胞移植中心
  • 收稿日期:2017-03-29 出版日期:2017-08-25
  • 通信作者: 黄孝伦
  • 基金资助:
    四川省人民医院院基金(临床研究及转化基金); 国家重点基础研究发展计划(973计划)(2015CB964703)

Progress and challenge of islet transplantation for type 1 diabetes mellitus

Xiaolun Huang1,()   

  1. 1. Sichuan Provincial People's Hospital, School of Medicine, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu 610072, China
  • Received:2017-03-29 Published:2017-08-25
  • Corresponding author: Xiaolun Huang
  • About author:
    Corresponding author: Huang Xiaolun, Email:
引用本文:

黄孝伦. 胰岛移植治疗1型糖尿病的进展与挑战[J]. 中华移植杂志(电子版), 2017, 11(03): 138-142.

Xiaolun Huang. Progress and challenge of islet transplantation for type 1 diabetes mellitus[J]. Chinese Journal of Transplantation(Electronic Edition), 2017, 11(03): 138-142.

随着外科移植技术的发展和胰岛分离纯化技术的改进,胰岛移植已成为治疗糖尿病的理想方法和手段。本文就目前胰岛移植治疗1型糖尿病的临床效果评价情况、面临的主要问题和解决方法,以及胰岛移植相关研究的进展与挑战展开述评。

With the development of transplantation surgery and the improvement of islet isolation technology, islet transplantation has become the ideal method of diabetes treatment.This paper reviewed recent advances in islet transplantation research, outlined current challenges and future directions in clinical islet transplantation.

1
Shaw JE,Sicree RA,Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030[J]. Diabetes Res Clin Pract, 2010, 87(1): 4-14.
2
Yang W,Lu J,Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010, 362(12): 1090-1110.
3
Scully T. Diabetes in numbers[J]. Nature, 2012, 485(7398): S2-S3.
4
Huang X,Moore DJ,Ketchum RJ, et al. Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation[J]. Endocr Rev, 2008, 29(5): 603-630.
5
Kelly WD,Lillehei RC,Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy[J]. Surgery, 1967, 61(6): 827-837.
6
Howell SL,Kostianovsky M,Lacy PE. Beta granules formation in isolated islets of langerhans: a study by electron microscopic radioautography[J]. J Cell Biol, 1969, 42(3): 695-705.
7
黄孝伦. 胰岛细胞移植治疗糖尿病的历史、现状与未来[J]. 中国普外基础与临床, 2012, 19(2): 125-128.
8
Ballinger WF,Lacy PE. Transplantation of intact pancreatic islets in rats[J]. Surgery, 1972, 72(2): 175-186.
9
Sutherland DE,Gores PF,Farney AC, et al. Evolution of kidney, pancreas, and islet transplantation for patients with diabetes at the University of Minnesota[J]. Am J Surg, 1993, 166(5): 456-491.
10
Ricordi C,Lacy PE,Finke EH, et al. Automated method for isolation of human pancreatic islets[J]. Diabetes, 1988, 37(4): 413-420.
11
Pyzdrowski KL,Kendall DM,Halter JB, et al. Preserved insulin secretion and insulin independence in recipients of islet autografts[J]. N Engl J Med, 1992, 327(4): 220-226.
12
Shapiro AM,Lakey JR,Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen[J]. N Engl J Med, 2000, 343(4): 230-238.
13
Markmann JF,Deng S,Desai NM, et al. The use of non-heart-beating donors for isolated pancreatic islet transplantation[J]. Transplantation, 2003, 75(9): 1423-1429.
14
Edlund H. Pancreatic organogenesis-developmental mechanisms and implications for therapy[J]. Nat Rev Genet, 2002, 3(7): 524-532.
15
Gerber PA,Locher R,Zuellig RA, et al. Glycemia, hypoglycemia, and costs of simultaneous islet-kidney or islet after kidney transplantation versus intensive insulin therapy and waiting list for islet transplantation[J]. Transplantation, 2015, 99(10): 2174-2180.
16
Borchers AT,Uibo R,Gershwin ME. The geoepidemiology of type 1 diabetes[J]. Autoimmun Rev, 2010, 9(5): A355-A365.
17
Ryan EA,Paty BW,Senior PA, et al.Five-year follow-up after clinical islet transplantation[J]. Diabetes, 2005, 54(7): 2060-2069.
18
Shapiro AM,Ricordi C,Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation[J]. N Engl J Med, 2006, 355(13): 1318-1330.
19
Brennan DC,Kopetskie HA,Sayre PH, et al. Long-term follow-up of the Edmonton protocol of islet transplantation in the United States[J]. Am J Transplant, 2016, 16(2): 509-517.
20
Jamiolkowski RM,Guo LY,Li YR, et al. Islet transplantation in type I diabetes mellitus[J]. Yale J Biol Med, 2012, 85(1): 37-43.
21
胡远峰,张洪,张洪德, 等.11例胰岛素依赖型糖尿病患者胰岛移植临床研究简报[J]. 上海医学, 1982, 5(8): 485-486.
22
李大伟,万初生. 我国首例成人胰岛细胞移植获得成功[J]. 首都医药, 2003, 10(8): 17.
23
谢平,穆会君,徐卓群, 等. 成人胰岛细胞的分离纯化及初步的临床应用[J]. 中华器官移植杂志, 2005, 26(6): 350-352.
24
蔡寒青,许世清,门秀丽, 等. 人胰岛的分离纯化和功能评价[J]. 中华医学杂志, 2009, 89(12): 836-840.
25
谭建明,蔡锦全,杨顺良, 等. 肾移植联合成人胰岛细胞移植治疗糖尿病肾病七例报告[J]. 中华泌尿外科杂志, 2009, 30(3): 168-171.
26
高海军,王浩,伊正甲, 等. 门静脉穿刺与封堵技术在胰岛细胞移植中的应用[J/CD]. 实用器官移植电子杂志, 2016, 4(6): 374-377.
27
黄孝伦,姚豫桐,罗兰云, 等. 同种胰岛细胞移植及采用改良Edmonton方案治疗1型糖尿病三例[J]. 中华器官移植杂志, 2014, 35(3): 160-164.
28
姚豫桐,魏玲玲,杨卯竹, 等. 同种异体胰岛移植治疗1型糖尿病10例及随访观察3年的临床研究[J]. 中华器官移植杂志, 2016, 37(2): 90-94.
29
姚豫桐,罗兰云,薛华, 等. 我国首例胰腺次全切除联合自体胰岛细胞移植治疗慢性胰腺炎临床分析[J]. 中国普外基础与临床杂志, 2013, 20(10): 1155-1158.
30
Noguchi H,Miyagi-Shiohira C,Kurima K, et al.Islet culture/preservation before islet transplantation[J]. Cell Med, 2015, 8(1-2): 25-29.
31
Hering BJ,Clarke WR,Bridges ND, et al.Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia[J]. Diabetes Care, 2016, 39: 1230-1240.
32
Ricordi C,Goldstein JS,Balamurugan AN, et al. National Institutes of Health-sponsored clinical islet transplantation consortium phase 3 trial: manufacture of a complex cellular product at eight processing facilities[J]. Diabetes, 2016, 65(11): 3418-3428.
33
Stegall MD,Dean PG,Sung R, et al. The rationale for the new deceased donor pancreas allocation schema[J]. Transplantation, 2007, 83(9): 1156-1161.
34
Hering BJ,Kandaswamy R,Ansite JD, et al. Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes[J]. JAMA, 2005, 293(7): 830-835.
35
Emamaullee JA,Shapiro AM. Factors influencing the loss of beta-cell mass in islet transplantation[J]. Cell Transplant, 2007, 16(1): 1-8.
36
Alejandro R,Barton F,Hering BJ, et al. 2008 update from the collaborative islet transplant registry[J]. Transplantation, 2008, 86(12): 1783-1788.
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