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中华移植杂志(电子版) ›› 2020, Vol. 14 ›› Issue (02) : 118 -123. doi: 10.3877/cma.j.issn.1674-3903.2020.02.014

所属专题: 文献

荟萃分析

HCV感染与肾移植后糖尿病关系的荟萃分析
李超1, 刘炎忠1, 刘志佳1, 柏宏伟1, 药晨1, 谢晓媚1, 李钢1, 余飞1, 解俊杰1, 石炳毅1,()   
  1. 1. 100091 北京,解放军总医院第八医学中心器官移植研究所;100091 北京,北京市器官移植和免疫调节重点实验室
  • 收稿日期:2019-09-01 出版日期:2020-04-25
  • 通信作者: 石炳毅
  • 基金资助:
    国家自然科学基金(81570680)

Relationship between hepatitis C virus infection and post transplantation diabetes mellitus: a meta-analysis

Chao Li1, Yanzhong Liu1, Zhijia Liu1, Hongwei Bai1, Chen Yao1, Xiaomei Xie1, Gang Li1, Fei Yu1, Junjie Xie1, Bingyi Shi1,()   

  1. 1. Organ Transplant Institute, the 8th Medical Center of Chinese PLA General Hospital, Beijing 100091, China; Beijing Key Laboratory of Organ Transplant and Immune Regulation, Beijing 100091, China
  • Received:2019-09-01 Published:2020-04-25
  • Corresponding author: Bingyi Shi
  • About author:
    Corresponding author: Shi Bingyi, Email:
引用本文:

李超, 刘炎忠, 刘志佳, 柏宏伟, 药晨, 谢晓媚, 李钢, 余飞, 解俊杰, 石炳毅. HCV感染与肾移植后糖尿病关系的荟萃分析[J/OL]. 中华移植杂志(电子版), 2020, 14(02): 118-123.

Chao Li, Yanzhong Liu, Zhijia Liu, Hongwei Bai, Chen Yao, Xiaomei Xie, Gang Li, Fei Yu, Junjie Xie, Bingyi Shi. Relationship between hepatitis C virus infection and post transplantation diabetes mellitus: a meta-analysis[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(02): 118-123.

目的

应用荟萃分析系统评价HCV感染是否为肾移植后糖尿病(PTDM)的相关危险因素。

方法

系统检索中国期刊全文数据库、中国生物医学数据库、PubMed数据库、Embase数据库、Google scholar和Web of science database截至2019年12月公开发表的相关文献。应用Stata 15.1统计软件使用随机效应模型进行荟萃分析,计算相对危险度(RR)。

结果

共纳入22篇文献,包含129 981例肾移植受者。荟萃分析结果显示,HCV感染的肾移植受者术后发生PTDM的风险为非HCV感染者的2.5倍(RR=2.50, 95%CI: 1.95~3.20, P<0.001)。在亚洲、高加索和美洲人种中,HCV感染均为肾移植术后PTDM的危险因素。

结论

HCV感染是促进肾移植术后发生PTDM的危险因素,感染者需尽早进行清除HCV的相关治疗。

Objective

To use a meta-analysis system to evaluate whether hepatitis C virus (HCV) infection is a risk factor for post transplantation diabetes mellitus (PTDM) in kidney transplant recipients.

Methods

All the papers published up to December 2019 in Chinese journal full-text database, Chinese biomedical database, PubMed database, Embase database, Google scholar and Web of science database had been systematically searched. A meta-analysis was performed using a random effects model using Stata 15.1 software to calculate relative risk (RR).

Results

A total of 22 articles including 129 981 kidney transplant recipients were included. The results of meta-analysis showed that HCV infected recipients did have an relative risk of PTDM by about 2.5 times to non HCV infected recipients (RR=2.50, 95%CI: 1.95-3.20, P<0.001). Subgroup analysis based on race found that HCV infection was a significant risk factor for PTDM after kidney transplantation in Asian, Caucasian, and American races.

Conclusions

HCV infection is a risk factor that promotes PTDM in recipients after kidney transplantation. Infected recipients should be treated as soon as possible to elimate HCV.

图1 文献检索流程图
表1 纳入文献的基本特征
图2 HCV感染与肾移植后糖尿病荟萃分析森林图
图3 HCV感染与肾移植后糖尿病根据随访时间的亚组分析
图4 HCV感染与肾移植后糖尿病荟萃分析漏斗图
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