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中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (01) : 36 -41. doi: 10.3877/cma.j.issn.1674-3903.2021.01.008

所属专题: 经典病例 文献

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肾移植术后并发移植后淋巴细胞增殖性疾病一例诊疗分析并文献复习
韦星1, 李响1,(), 陈昌庆1, 金海龙1, 蔡明1   
  1. 1. 100091 北京,解放军总医院第八医学中心器官移植中心泌尿外科
  • 收稿日期:2020-10-26 出版日期:2021-02-25
  • 通信作者: 李响

Diagnosis and treatment of post-transplant lymphoproliferative disorder confined to renal allograft and literature review

Xing Wei1, Xiang Li1,(), Changqing Chen1, Hailong Jin1, Ming Cai1   

  1. 1. Department of Organ Transplantation and Urology, the 8th Medical Center of Chinese People′s Liberation Army General Hospital, Beijing 100091, China
  • Received:2020-10-26 Published:2021-02-25
  • Corresponding author: Xiang Li
引用本文:

韦星, 李响, 陈昌庆, 金海龙, 蔡明. 肾移植术后并发移植后淋巴细胞增殖性疾病一例诊疗分析并文献复习[J/OL]. 中华移植杂志(电子版), 2021, 15(01): 36-41.

Xing Wei, Xiang Li, Changqing Chen, Hailong Jin, Ming Cai. Diagnosis and treatment of post-transplant lymphoproliferative disorder confined to renal allograft and literature review[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(01): 36-41.

图1 2019年8月3日受者移植肾影像学检查结果
表1 累及移植肾的PTLD国内外文献报道
参考文献 病例编号 免疫抑制方案 年龄(岁) 性别 发生距移植时间(月) 临床症状 EB病毒 治疗方案 病理诊断 预后
卢峡等[13] 1 他克莫司+MMF+泼尼松 47 27 移植肾区肿胀 阳性 CHOP 单形性PTLD 随访12年未见复发
  2 环孢素+MMF+泼尼松 52 7 阳性 利妥昔单抗+CHOP 多形性PTLD 随访2年肿物未增大,移植肾功能正常
陈雁扬等[14] 3 环孢素+MMF+泼尼松 42 18 阳性 手术切除 多形性PTLD 随访1年半未复发
王照明等[15] 4 环孢素+MMF+泼尼松 - 6 阴性 手术切除 单形性PTLD 随访4个月后死亡
  5 环孢素+硫唑嘌呤+泼尼松 - 12 阳性 CHOP 单形性PTLD 随访2个月后死亡
宋少伟等[16] 6 环孢素+MMF+泼尼松 52 12 血尿 未知 手术切除 多形性PTLD 随访2个月未发现复发
吴轲等[17] 7 他克莫司+MMF+泼尼松 47 26 移植肾区肿胀 阳性 CHOP 单形性PTLD 随访18个月肿物缩小,移植肾功能正常
Shustik等[18] 8 硫唑嘌呤+泼尼松 45 171 未知 手术切除 单形性PTLD 随访33个月未见复发
Meehan等[19] 9 环孢素+硫唑嘌呤+泼尼松 59 84 阴性 手术切除 单形性PTLD 随访12个月未见复发
  10 环孢素+硫唑嘌呤+泼尼松 14 12 阴性 手术切除 单形性PTLD 随访24个月未见复发
  11 他克莫司+硫唑嘌呤+泼尼松 12 17 阴性 手术切除 单形性PTLD 随访1个月后死亡
Kuppachi等[20] 12 他克莫司+MMF+泼尼松 45 18 阳性 手术切除 单形性PTLD 随访23个月未见复发
Thibaud等[21] 13 他克莫司+MMF+泼尼松 69 36 阳性 RCD 单形性PTLD 随访48个月未见复发
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