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中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (03) : 174 -178. doi: 10.3877/cma.j.issn.1674-3903.2022.03.009

综述

儿童肝移植术后淋巴增殖性疾病研究进展
施丹1, 高志刚2,()   
  1. 1. 310003 杭州,浙江大学医学院附属儿童医院 国家儿童健康与疾病临床医学研究中心儿内科
    2. 310003 杭州,浙江大学医学院附属儿童医院 国家儿童健康与疾病临床医学研究中心普外科
  • 收稿日期:2022-05-17 出版日期:2022-06-25
  • 通信作者: 高志刚
  • 基金资助:
    浙江省医药卫生科技计划省部共建重点项目(WKJ-ZJ-2120); 国家自然科学基金重点项目(81930016)

Progress of post-transplant lymphoproliferative disorder after pediatric liver transplantation

Dan Shi1, Zhigang Gao2,()   

  1. 1. Department of Internal Medicine, The Children′s Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China
    2. Department of General Surgery, The Children′s Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2022-05-17 Published:2022-06-25
  • Corresponding author: Zhigang Gao
引用本文:

施丹, 高志刚. 儿童肝移植术后淋巴增殖性疾病研究进展[J]. 中华移植杂志(电子版), 2022, 16(03): 174-178.

Dan Shi, Zhigang Gao. Progress of post-transplant lymphoproliferative disorder after pediatric liver transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(03): 174-178.

肝移植是儿童终末期肝病的唯一治疗方法,手术技术进步和免疫抑制剂发展极大地提高了儿童肝移植受者生存率。移植后淋巴增殖性疾病(PTLD)是儿童肝移植术后危及生命的并发症,与移植术后受者免疫抑制水平、EB病毒DNA载量等密切相关。PTLD的诊治目前存在一定困难,受者预后不佳。本文就近年来儿童肝移植后PTLD相关研究进展作一综述。

Liver transplantation is the only treatment for children with end-stage liver disease. Advances in surgical techniques and immunosuppressive agents have greatly improved the recipients′ prognosis after liver transplantation. Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after pediatric liver transplantation. It is closely related to the level of immunosuppression and Epstein-Barr virus DNA replication load in pediatric recipients after liver transplantation. There are certain difficulties in the diagnosis and treatment of PTLD, and the prognosis of the recipients is poor. This article reviews the recent research progress on PTLD following pediatric liver transplantation.

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