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中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (03) : 174 -178. doi: 10.3877/cma.j.issn.1674-3903.2022.03.009

综述

儿童肝移植术后淋巴增殖性疾病研究进展
施丹1, 高志刚2,()   
  1. 1. 310003 杭州,浙江大学医学院附属儿童医院 国家儿童健康与疾病临床医学研究中心儿内科
    2. 310003 杭州,浙江大学医学院附属儿童医院 国家儿童健康与疾病临床医学研究中心普外科
  • 收稿日期:2022-05-17 出版日期:2022-06-25
  • 通信作者: 高志刚
  • 基金资助:
    浙江省医药卫生科技计划省部共建重点项目(WKJ-ZJ-2120); 国家自然科学基金重点项目(81930016)

Progress of post-transplant lymphoproliferative disorder after pediatric liver transplantation

Dan Shi1, Zhigang Gao2,()   

  1. 1. Department of Internal Medicine, The Children′s Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China
    2. Department of General Surgery, The Children′s Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2022-05-17 Published:2022-06-25
  • Corresponding author: Zhigang Gao
引用本文:

施丹, 高志刚. 儿童肝移植术后淋巴增殖性疾病研究进展[J/OL]. 中华移植杂志(电子版), 2022, 16(03): 174-178.

Dan Shi, Zhigang Gao. Progress of post-transplant lymphoproliferative disorder after pediatric liver transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(03): 174-178.

肝移植是儿童终末期肝病的唯一治疗方法,手术技术进步和免疫抑制剂发展极大地提高了儿童肝移植受者生存率。移植后淋巴增殖性疾病(PTLD)是儿童肝移植术后危及生命的并发症,与移植术后受者免疫抑制水平、EB病毒DNA载量等密切相关。PTLD的诊治目前存在一定困难,受者预后不佳。本文就近年来儿童肝移植后PTLD相关研究进展作一综述。

Liver transplantation is the only treatment for children with end-stage liver disease. Advances in surgical techniques and immunosuppressive agents have greatly improved the recipients′ prognosis after liver transplantation. Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after pediatric liver transplantation. It is closely related to the level of immunosuppression and Epstein-Barr virus DNA replication load in pediatric recipients after liver transplantation. There are certain difficulties in the diagnosis and treatment of PTLD, and the prognosis of the recipients is poor. This article reviews the recent research progress on PTLD following pediatric liver transplantation.

1
Qin T, Gu XQ, Jeong SS, et al. Impact of EBV infection and immune function assay for lymphoproliferative disorder in pediatric patients after liver transplantation: a single-center experience[J]. Hepatobiliary Pancreat Dis Int, 202019(1):3-11.
2
Wang T, Feng M, Luo C, et al. Successful treatment of pediatric refractory Burkitt lymphoma PTLD after liver transplantation using anti-CD19 chimeric antigen receptor T-cell therapy[J]. Cell Transplant, 202130:963689721996649.
3
陈奥,练巧燕,张建恒,等. 移植后淋巴增殖性疾病研究进展[J/CD]. 中华移植杂志:电子版202115(5): 307-312.
4
Caillard S, Porcher R, Provot F, et al. Post-transplantation lymphoproliferative disorder after kidney transplantation: report of a nationwide French registry and the development of a new prognostic score[J]. J Clin Oncol, 201331(10):1302-1309.
5
Tajima T, Hata K, Haga H, et al. Post-transplant lymphoproliferative disorders after liver transplantation: a retrospective cohort study including 1954 transplants[J]. Liver Transpl, 202127(8):1165-1180.
6
Wasuwanich P, Batsis I, Thawillarp S, et al. Post-transplant eosinophilic gastrointestinal disorders and lymphoproliferative disorder in pediatric liver transplant recipients on tacrolimus[J]. Transpl Immunol, 202168:101438.
7
Baker A, Frauca Remacha E, Torres Canizales J, et al. Current practices on diagnosis, prevention and treatment of post-transplant lymphoproliferative disorder in pediatric patients after solid organ transplantation: results of ERN Transplant Child Healthcare Working Group Survey[J]. Children (Basel), 20218(8):661.
8
Éboli LPCB, Tannuri ACA, Tannuri U. Seropositivity for cytomegalovirus and PCR-EBV monitoring: protective factors for posttransplant lymphoproliferative disorder in pediatric liver transplant[J]. Pediatr Transplant, 202226(4):e14226.
9
Akbas A, Tiede C, Lemound J, et al. Post-transplant lymphoproliferative disorders with naso- and oropharyngeal manifestation[J]. Transpl Int, 201528(11):1299-1307.
10
Walti LN, Mugglin C, Sidler D, et al. Association of antiviral prophylaxis and rituximab use with posttransplant lymphoproliferative disorders (PTLDs): a nationwide cohort study[J]. Am J Transplant, 202121(7):2532-2542.
11
Kampers J, Orjuela-Grimm M, Schober T, et al. Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules [J]. Leuk Lymphoma, 201758(3):633-638.
12
刘静怡,孙丽莹,朱志军,等. 儿童肝移植后淋巴组织增生性疾病诊疗分析[J/CD]. 实用器官移植电子杂志20219(3): 183-189.
13
Tsao L, Hsi ED. The clinicopathologic spectrum of posttransplantation lymphoproliferative disorders[J]. Arch Pathol Lab Med, 2007, 131(8):1209-1218.
14
Ghigna MR, Reineke T, Rincé P, et al. Epstein-Barr virus infection and altered control of apoptotic pathways in posttransplant lymphoproliferative disorders[J]. Pathobiology, 201380(2):53-59.
15
Opelz G, Daniel V, Naujokat C, et al. Epidemiology of pretransplant EBV and CMV serostatus in relation to posttransplant non-Hodgkin lymphoma[J]. Transplantation, 200988(8):962-967.
16
Dharnidharka VR, Lamb KE, Gregg JA, et al. Associations between EBV serostatus and organ transplant type in PTLD risk: an analysis of the SRTR National Registry Data in the United States[J]. Am J Transplant, 201212(4):976-983.
17
Dierickx D, Habermann TM. Post-transplantation lymphoproliferative disorders in adults[J]. N Engl J Med, 2018378(6):549-562.
18
Younes BS, McDiarmid SV, Martin MG, et al. The effect of immunosuppression on posttransplant lymphoproliferative disease in pediatric liver transplant patients[J]. Transplantation, 200070(1):94-99.
19
Chardot C, Nicoluzzi JE, Janssen M, et al. Use of mycophenolate mofetil as rescue therapy after pediatric liver transplantation[J]. Transplantation, 200171(2):224-229.
20
Sindhi R, Webber S, Venkataramanan R, et al. Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus[J]. Transplantation, 200172(5):851-855.
21
Kwong AJ, Fix OK. Update on the management of the liver transplant patient[J]. Curr Opin Gastroenterol, 201531(3):224-232.
22
Kremers WK, Devarbhavi HC, Wiesner RH, et al. Post-transplant lymphoproliferative disorders following liver transplantation: incidence, risk factors and survival[J]. Am J Transplant, 20066(5 Pt 1):1017-1024.
23
Zimmermann T, Hoppe-Lotichius M, Tripkovic V, et al. Liver transplanted patients with preoperative autoimmune hepatitis and immunological disorders are at increased risk for post-transplant lymphoproliferative disease (PTLD) [J]. Eur J Intern Med, 201021(3):208-215.
24
Hézode C, Duvoux C, Germanidis G, et al. Role of hepatitis C virus in lymphoproliferative disorders after liver transplantation[J]. Hepatology, 199930(3):775-778.
25
Kinch A, Baecklund E, Backlin C, et al. A population-based study of 135 lymphomas after solid organ transplantation: the role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival[J]. Acta Oncol, 201453(5):669-679.
26
Zhang A, Zhang M, Shen Y, et al. Hepatitis B virus reactivation is a risk factor for development of post-transplant lymphoproliferative disease after liver transplantation[J]. Clin Transplant, 200923(5):756-760.
27
Panagiotidis E, Quigley AM, Pencharz D, et al. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in diagnosis of post-transplant lymphoproliferative disorder[J]. Leuk Lymphoma, 201455(3):515-519.
28
Aguilera N, Gru AA. Reexamining post-transplant lymphoproliferative disorders: newly recognized and enigmatic types[J]. Semin Diagn Pathol, 201835(4):236-246.
29
Hanto DW, Frizzera G, Gajl-Peczalska KJ, et al. Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation[J]. N Engl J Med, 1982306(15):913-918.
30
Green M, Kaufmann M, Wilson J, et al. Comparison of intravenous ganciclovir followed by oral acyclovir with intravenous ganciclovir alone for prevention of cytomegalovirus and Epstein-Barr virus disease after liver transplantation in children[J]. Clin Infect Dis, 199725(6):1344-1349.
31
Jarasvaraparn C, Choudhury S, Rusch C, et al. Characteristics, risk factors, and outcomes of neutropenia after liver or kidney transplantation in children[J]. Pediatr Transplant, 202226(1):e14131.
32
Trappe R, Riess H, Anagnostopoulos I, et al. Efficiency of antiviral therapy plus IVIG in a case of primary EBV infection associated PTLD refractory to rituximab, chemotherapy, and antiviral therapy alone[J]. Ann Hematol, 200988(2):167-172.
33
Lindsay J, Othman J, Heldman MR, et al. Epstein-Barr virus posttransplant lymphoproliferative disorder: update on management and outcomes[J]. Curr Opin Infect Dis, 202134(6):635-645.
34
Chen HS, Ho MC, Hu RH, et al. Roles of Epstein-Barr virus viral load monitoring in the prediction of posttransplant lymphoproliferative disorder in pediatric liver transplantation[J]. J Formos Med Assoc, 2019118(9):1362-1368.
35
McDiarmid SV, Jordan S, Kim GS, et al. Prevention and preemptive therapy of posttransplant lymphoproliferative disease in pediatric liver recipients[J]. Transplantation, 199866(12):1604-1611.
36
Lee TC, Savoldo B, Rooney CM, et al. Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients[J]. Am J Transplant, 20055(9):2222-2228.
37
Swinnen LJ, LeBlanc M, Grogan TM, et al. Prospective study of sequential reduction in immunosuppression, interferon alpha-2B, and chemotherapy for posttransplantation lymphoproliferative disorder[J]. Transplantation, 200886(2):215-222.
38
Parker A, Bowles K, Bradley JA, et al. Management of post-transplant lymphoproliferative disorder in adult solid organ transplant recipients-BCSH and BTS Guidelines[J]. Br J Haematol, 2010149(5):693-705.
39
Tsai DE, Hardy CL, Tomaszewski JE, et al. Reduction in immunosuppression as initial therapy for posttransplant lymphoproliferative disorder: analysis of prognostic variables and long-term follow-up of 42 adult patients[J]. Transplantation, 200171(8):1076-1088.
40
Reshef R, Vardhanabhuti S, Luskin MR, et al. Reduction of immunosuppression as initial therapy for posttransplantation lymphoproliferative disorder[J]. Am J Transplant, 201111(2):336-347.
41
Trappe RU, Dierickx D, Zimmermann H, et al. Response to rituximab induction is a predictive marker in B-cell post-transplant lymphoproliferative disorder and allows successful stratification into rituximab or R-CHOP consolidation in an international, prospective, multicenter phase Ⅱ trial [J]. J Clin Oncol, 201735(5):536-543.
42
Trappe R, Oertel S, Leblond V, et al. Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial[J]. Lancet Oncol, 201213(2):196-206.
43
Dang BN, Ch′ng J, Russell M, et al. Treatment of post-transplant lymphoproliferative disorder (PTLD) in a heart transplant recipient with chimeric antigen receptor T-cell therapy[J]. Pediatr Transplant, 202125(5):e13861.
44
Perica K, Varela JC, Oelke M, et al. Adoptive T cell immunotherapy for cancer[J]. Rambam Maimonides Med J, 20156(1):e0004.
45
Papadopoulos EB, Ladanyi M, Emanuel D, et al. Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation[J]. N Engl J Med, 1994330(17):1185-1191.
46
Dharnidharka VR, Mohanakumar T. New approaches to treating B-cell cancers induced by Epstein-Barr virus[J]. N Engl J Med, 2015372(6):569-571.
47
陶媛,汝昆. 移植后淋巴组织增殖性疾病的诊疗特点及进展[J/CD]. 实用器官移植电子杂志2019, 7(5): 401-405.
48
Mumtaz K, Faisal N, Marquez M, et al. Post-transplant lymphoproliferative disorder in liver recipients: characteristics, management, and outcome from a single-centre experience with >1000 liver transplantations[J]. Can J Gastroenterol Hepatol, 201529(8):417-422.
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