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中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (04) : 249 -255. doi: 10.3877/cma.j.issn.1674-3903.2022.04.010

综述

活体肝移植供肝脂肪变性评估研究进展
张晋平1, 朱志军1,†(), 孙丽莹2, 魏林1, 曲伟1, 曾志贵1, 张海明1   
  1. 1. 100050　首都医科大学附属北京友谊医院肝移植中心
    2. 100050　首都医科大学附属北京友谊医院肝移植中心；100050　首都医科大学附属北京友谊医院重症肝病科
  • 收稿日期:2022-08-12 出版日期:2022-08-25
  • 通信作者: 朱志军

Research progress of hepatic steatosis evaluation evaluate in living donor liver transplantation

Jinping Zhang1, Zhijun Zhu1,†(), Liying Sun2, Lin Wei1, Wei Qu1, Zhigui Zeng1, Haiming Zhang1   

  1. 1. Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, 100050 Beijing, China
    2. Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, 100050 Beijing, China; Department of Severe Liver Disease, Beijing Friendship Hospital, Capital Medical University, 100050 Beijing, China
  • Received:2022-08-12 Published:2022-08-25
  • Corresponding author: Zhijun Zhu
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引用本文：

张晋平, 朱志军, 孙丽莹, 魏林, 曲伟, 曾志贵, 张海明. 活体肝移植供肝脂肪变性评估研究进展[J]. 中华移植杂志(电子版), 2022, 16(04): 249-255.

Jinping Zhang, Zhijun Zhu, Liying Sun, Lin Wei, Wei Qu, Zhigui Zeng, Haiming Zhang. Research progress of hepatic steatosis evaluation evaluate in living donor liver transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(04): 249-255.

脂肪变性供肝作为边缘性供肝，已成为扩展供肝来源的重要渠道。因此，肝移植术前评估供肝脂肪变性程度尤为重要。临床判断肝脂肪变性发展程度以肝穿刺活检结果作为依据，但给患者带来一定创伤风险。随着影像学和生物学检测技术的不断发展，超声、CT、MRI、磁共振波谱分析和生物标志物等已被用于评估肝移植供肝脂肪变性程度。本文综述上述临床手段在评估脂肪变性供肝质量方面的研究进展，分析其在临床应用中的优缺点，为临床安全、快速和无创评估脂肪变性供肝提供参考。

关键词: 活体肝移植, 脂肪肝, 评价手段, 脂肪变性

Donor livers with steatosis as a type of marginal donor livers, has become an important channel to expand the source of donor livers. Therefore, it is important to evaluate the degree of steatosis before liver transplantation. The clinical judgment on the state of hepatic steatosis is based on the results of liver biopsy, but it brings a certain risk of trauma to patients. With the continuous development of imaging and biological detection technologies. The clinical methods including ultrasound, CT, MRI, magnetic resonance spectroscopy and biomarkers have been used to evaluate the degree of hepatic steatosis in liver transplantation. This article reviews the research progress of the above clinical methods in assessing the quality of donor liver with steatosis, and analyzes their advantages and disadvantages in clinical application, and provides a reference for the safe, rapid and non-invasive assessment of donor liver with steatosis.

Key words: Living liver transplantation, Fatty liver, Evaluation method, Steatosis
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