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中华移植杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 268 -273. doi: 10.3877/cma.j.issn.1674-3903.2025.04.010

综述

间充质干细胞来源外泌体在肝再生领域的应用
黄淳雨, 李文馨, 蒋上, 陈佳佳()   
  1. 310003 杭州,浙江大学医学院附属第一医院感染科
  • 收稿日期:2025-02-13 出版日期:2025-08-25
  • 通信作者: 陈佳佳
  • 基金资助:
    国家重点研发计划(2023YFC2308802)

Application of mesenchymal stem cell-derived exosomes in liver regeneration

Chunyu Huang, Wenxin Li, Shang Jiang, Jiajia Chen()   

  1. Department of Infection, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2025-02-13 Published:2025-08-25
  • Corresponding author: Jiajia Chen
引用本文:

黄淳雨, 李文馨, 蒋上, 陈佳佳. 间充质干细胞来源外泌体在肝再生领域的应用[J/OL]. 中华移植杂志(电子版), 2025, 19(04): 268-273.

Chunyu Huang, Wenxin Li, Shang Jiang, Jiajia Chen. Application of mesenchymal stem cell-derived exosomes in liver regeneration[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2025, 19(04): 268-273.

肝脏具有强大再生能力,但在某些情况下,如肝纤维化、肝硬化或急性肝损伤,肝脏的自我修复能力受到抑制,导致疾病进展。间充质干细胞(MSCs)以其独特的生物学特性,在疾病治疗和再生医学中展现出重要的潜力,但其有肿瘤发生、移植排斥反应等风险。MSCs来源外泌体(MSC-Exos)具有与其相当的功能,且更安全,作为一种新的无细胞疗法,为疾病诊疗提供了新方向。MSC-Exos可通过调控自噬和炎症反应、抗氧化应激、抗肝细胞凋亡及促进血管再生等机制有效促进肝再生。本文主要对MSC-Exos特性及其对肝再生的可能作用机制进行综述,以期促进MSC-Exos在肝再生领域的应用。

The liver has a strong regenerative capacity, but in some cases, such as liver fibrosis, cirrhosis, or acute liver injury, the liver′s ability to repair itself is inhibited, leading to disease progression. Mesenchymal stem cells (MSCs), with their unique biological properties, show important potential in disease treatment and regenerative medicine, but they carry risks such as tumorigenesis and transplant rejection. MSC-derived exosomes (MSC-Exos) have comparable functions to them and are safer, providing a new direction for disease diagnosis and treatment as a new cell-free therapy. MSC-Exos can effectively promote liver regeneration by regulating autophagy and inflammatory responses, exerting antioxidant effects, inhibiting hepatocyte apoptosis, and promoting angiogenesis. This article primarily reviews the characteristics of MSC-Exos and their potential mechanisms in liver regeneration, aiming to facilitate the application of MSC-Exos in the field of liver regeneration.

图1 间充质干细胞来源外泌体通过调节自噬、炎症反应改善肝损伤示意图注:STAT3.信号转导及转录活化因子;mTOR.哺乳动物雷帕霉素靶蛋白;LC3 Ⅱ.微管相关蛋白1轻链3 Ⅱ;LPS/TLR4.脂多糖/ Toll样受体4; NLRP3. NOD样受体热蛋白结构域相关蛋白3; PIK3r1.磷脂酰肌醇3-激酶调节亚基1
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