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中华移植杂志(电子版) ›› 2026, Vol. 20 ›› Issue (01) : 38 -45. doi: 10.3877/cma.j.issn.1674-3903.2026.01.004

专家共识

成人HIV感染合并淋巴瘤患者自体造血干细胞移植专家共识(2026版)
国家感染性疾病临床医学研究中心, 国家传染病医学中心, 长三角地区艾滋病脆弱人群诊治协作组, 浙江省医学会热带病与寄生虫病学分会艾滋病学组   
  1. 1. 国家感染性疾病临床医学研究中心,国家传染病医学中心,浙江大学医学院附属第一医院感染病科,310003 杭州
    2. 浙江大学医学院附属第一医院血液骨髓移植中心,310003 杭州
  • 收稿日期:2026-01-05 出版日期:2026-02-25
  • 基金资助:
    新发突发与重大传染病防控国家科技重大专项(2025ZD01905000)

Expert consensus on autologous hematopoietic stem cell transplantation for adult patients with human immunodeficiency virus infection complicated by lymphoma (2026 version)

National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Yangtze River Delta Collaborative Group for Diagnosis and Treatment of Vulnerable Population with HIV/AIDS, AIDS Group, Society of Tropical Diseases and Parasitology, Zhejiang Medical Association   

  1. 1. National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Department of Infectious Diseases, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003
    2. Hematology and Bone Marrow Transplantation Center, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003
  • Received:2026-01-05 Published:2026-02-25
引用本文:

国家感染性疾病临床医学研究中心, 国家传染病医学中心, 长三角地区艾滋病脆弱人群诊治协作组, 浙江省医学会热带病与寄生虫病学分会艾滋病学组. 成人HIV感染合并淋巴瘤患者自体造血干细胞移植专家共识(2026版)[J/OL]. 中华移植杂志(电子版), 2026, 20(01): 38-45.

National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Yangtze River Delta Collaborative Group for Diagnosis and Treatment of Vulnerable Population with HIV/AIDS, AIDS Group, Society of Tropical Diseases and Parasitology, Zhejiang Medical Association. Expert consensus on autologous hematopoietic stem cell transplantation for adult patients with human immunodeficiency virus infection complicated by lymphoma (2026 version)[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2026, 20(01): 38-45.

成人HIV感染合并淋巴瘤患者自体造血干细胞移植(auto-HSCT)是治疗高危或复发性淋巴瘤的重要手段之一。然而,相较于欧美国家,我国HIV感染患者auto-HSCT的规范化和专业化管理方面仍存在较大差距。为解决这一问题,国家感染性疾病临床医学研究中心、国家传染病医学中心、长三角地区艾滋病脆弱人群诊治协作组和浙江省医学会热带病与寄生虫病学分会艾滋病学组联合相关领域专家,结合国内主要auto-HSCT中心的经验及国际最新研究进展,制订本专家共识。共识涵盖移植前评估与准备(auto-HSCT适应证和患者评估)、auto-HSCT的实施(造血干细胞动员及采集时机、移植流程、相关并发症及处理原则和移植期间护理)及随访管理(移植后维持治疗、造血重建评估、免疫重建监测和随访)等多个方面,旨在为国内临床医师提供科学、规范的指导,优化HIV感染合并淋巴瘤患者auto-HSCT的治疗效果,提高其长期生存获益。

Autologous hematopoietic stem cell transplantation (auto-HSCT) is a crucial therapeutic modality for high-risk or relapsed lymphoma in adults with HIV infection. However, compared with Europe and American countries, China still faces significant gaps in the standardized and specialized management of auto-HSCT for HIV-positive patients. To address this issue, the National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Yangtze River Delta Collaborative Group for Diagnosis and Treatment of Vulnerable Population with HIV/AIDS, AIDS Group, Society of Tropical Diseases and. Parasitology, Zhejiang Medical Association, jointly with experts from relevant fields, have developed this expert consensus by integrating the experience of major domestic auto-HSCT centers and the latest international research advances. This consensus covers multiple aspects, including pre-transplant evaluation and preparation (indications for auto-HSCT and patient assessment), implementation of auto-HSCT (timing of hematopoietic stem cell mobilization and collection, transplant procedure, management principles for related complications, and peri-transplant care), and post-transplant follow-up management (post-transplant maintenance therapy, hematopoietic reconstitution, immune reconstitution, and follow-up). It aims to provide scientific and standardized guidance for domestic clinicians, optimize the therapeutic outcomes of auto-HSCT in patients with HIV-associated lymphoma, and improve their long-term survival benefits.

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