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中华移植杂志(电子版) ›› 2018, Vol. 12 ›› Issue (03) : 139 -142. doi: 10.3877/cma.j.issn.1674-3903.2018.03.010

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综述

他汀类药物减轻肝脏缺血再灌注损伤的研究进展
刘忠忠1, 叶少军1, 张行健1, 王彦峰1, 叶啟发2,()   
  1. 1. 430071 武汉大学中南医院 武汉大学肝胆疾病研究院 武汉大学移植医学中心 移植医学技术湖北省重点实验室
    2. 430071 武汉大学中南医院 武汉大学肝胆疾病研究院 武汉大学移植医学中心 移植医学技术湖北省重点实验室;410013 长沙,中南大学湘雅三医院 卫生部移植医学工程技术研究中心
  • 收稿日期:2018-01-11 出版日期:2018-08-25
  • 通信作者: 叶啟发
  • 基金资助:
    国家自然科学基金新疆联合基金资助项目(U1403222)

Research advances of statins on liver ischemic reperfusion injury

Zhongzhong Liu1, Shaojun Ye1, Xingjian Zhang1, Yanfeng Wang1, Qifa Ye2,()   

  1. 1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
    2. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China; the Third Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha 410013, China
  • Received:2018-01-11 Published:2018-08-25
  • Corresponding author: Qifa Ye
  • About author:
    Corresponding author: Ye Qifa, Email:
引用本文:

刘忠忠, 叶少军, 张行健, 王彦峰, 叶啟发. 他汀类药物减轻肝脏缺血再灌注损伤的研究进展[J/OL]. 中华移植杂志(电子版), 2018, 12(03): 139-142.

Zhongzhong Liu, Shaojun Ye, Xingjian Zhang, Yanfeng Wang, Qifa Ye. Research advances of statins on liver ischemic reperfusion injury[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2018, 12(03): 139-142.

缺血再灌注损伤(IRI)是肝切除和肝移植不可避免的损伤过程,也是肝移植主要的损伤危险因素之一,影响肝移植受者术后近、远期疗效。他汀类药物能上调内皮细胞Kruppel样因子2表达,产生抗炎、抗血栓形成、抗氧化应激、抗凋亡等保护作用。本文主要综述他汀类药物减轻肝脏IRI的研究进展。

Ischemic reperfusion injury is almost unavoidable in liver resection surgery and liver transplantation, which is also one of the major risk factors of liver transplantation and affects the short-term and long-term outcome of liver transplantation recipients. Previous study found that Kruppel-like factor 2 induced by stains play an protective role in the regulation of endothelial function, such as anti-inflammation, anti-thrombosis, anti-oxidant stress, anti-apoptosis, and so on. This review summarizes the current understanding of statins on liver ischemic reperfusion injury.

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