肝移植术后妊娠的挑战与进展

doi:10.3877/cma.j.issn.1674-3903.2022.02.012

中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 119 -121. doi: 10.3877/cma.j.issn.1674-3903.2022.02.012

综述

肝移植术后妊娠的挑战与进展

王益如¹, 阳新宇², 牛诤³, 孙丽萍³, 徐骁²^,^†(

)

^1. 310003　浙江大学医学院附属杭州市第一人民医院妇科；671000　大理大学第一附属医院妇科
^2. 310003　浙江大学医学院附属杭州市第一人民医院肝胆胰外科
^3. 310003　浙江大学医学院附属杭州市第一人民医院妇科

收稿日期:2021-12-14 出版日期:2022-04-25
通信作者: 徐骁

Challenge and progress of pregnancy after liver transplantation

Yiru Wang¹, Xinyu Yang², Zheng Niu³, Liping Sun³, Xiao Xu²^,^†()

^1. Department of Gynecology, Affiliated Hangzhou First People′s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Department of Gynecology, College of Clinical Medicine, Dali University, Dali 671000, China
^2. Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People′s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
^3. Department of Gynecology, Affiliated Hangzhou First People′s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

Received:2021-12-14 Published:2022-04-25
Corresponding author: Xiao Xu

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肝移植是终末期肝脏疾病最有效的治疗方法。随着肝移植外科技术日趋成熟及围手术期管理水平的不断提高，肝移植受者预后明显改善。接受肝移植的女童和育龄妇女也日益增多，术后长期生存中有着潜在的生育需求。但肝移植术后妊娠较正常妊娠面临更为复杂的情况，妊娠期并发症、移植肝状况和胎儿异常风险等问题均不容忽视。肝移植术后妊娠在肝移植受者长期管理中的重要性日益凸显，应纳入规范化临床诊治体系。本文对近年来肝移植术后妊娠研究进展作一综述，以提高临床实践中对肝移植术后妊娠的认知和重视。

关键词: 肝移植, 妊娠, 免疫抑制

Liver transplantation is the most effective treatment for end-stage liver diseases. With the advances in surgical techniques and perioperative managements, the prognosis of liver transplantation recipients has been improved remarkably. The increasing number of women of reproductive age and girls who underwent liver transplantation raised the importance of potential reproductive needs in the long-term postoperative survival. However, owing to the increased risk of complication in pregnancy, fetal anomalies and graft status, pregnancy after liver transplantation is more complicated than normal pregnancy. Considering the importance in the long-term management of liver transplantation recipients, it is necessary to incorporate the pregnancy after liver transplantation into standardized clinical diagnosis and treatment system. Here, aiming to elevate the cognition and attention of pregnancy after liver transplantation in clinical practice, this review examined the domestic and overseas research results, and comprehensively elucidated the progress of pregnancy after liver transplantation.

Key words: Liver transplantation, Pregnancy, Immunosuppression

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