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中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (04) : 193 -200. doi: 10.3877/cma.j.issn.1674-3903.2022.04.001

诊疗规范

肾移植受者人类微小病毒B19感染临床诊疗技术规范(2022版)
中华医学会器官移植学分会, 国家肾脏移植质控中心   
  • 收稿日期:2022-01-02 出版日期:2022-08-25
  • 基金资助:
    国家自然科学基金面上项目(82070768)

Technical specification for clinical diagnosis and treatment of human parvovirus B19 infection in kidney transplant recipients (2022 edition)

Branch of Organ Transplantation of Chinese Medical Association, National Kidney Transplantation Quality Control Center   

  • Received:2022-01-02 Published:2022-08-25
  • About author:
    The 3th Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
引用本文:

中华医学会器官移植学分会, 国家肾脏移植质控中心. 肾移植受者人类微小病毒B19感染临床诊疗技术规范(2022版)[J/OL]. 中华移植杂志(电子版), 2022, 16(04): 193-200.

Branch of Organ Transplantation of Chinese Medical Association, National Kidney Transplantation Quality Control Center. Technical specification for clinical diagnosis and treatment of human parvovirus B19 infection in kidney transplant recipients (2022 edition)[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(04): 193-200.

肾移植受者长期使用免疫抑制剂,导致其免疫功能低下,容易伴发各种病原体感染。近年来随着人类微小病毒B19(HPV-B19)感染的检测技术发展和肾移植手术的增多,肾移植术后HPV-B19的感染率呈逐年上升的趋势,是导致术后纯红细胞再生障碍性贫血的重要原因之一,影响移植肾功能恢复,甚至导致移植肾损伤或预后不良。为了进一步规范肾移植受者HPV-B19感染的诊断和治疗,中华医学会器官移植学分会和国家肾脏移植质控中心组织专家,从HPV-B19病原学、流行病学特点、临床表现、诊断、预防、治疗、存在的问题及展望等方面,制订肾移植术后HPV-B19感染的临床诊疗规范,以期为我国肾移植术后HPV-B19感染的规范化防治提供指导。

Long-term use of immunosuppressant in kidney transplant recipients leads to poor immune function and infection with various pathogens. In recent years, along with the advancement of detection technique of human parvovirus B19 (HPV-B19) infection and the increasing quantity of kidney transplantation, the infection rate of HPV-B19 after kidney transplantation has been elevated year by year, becoming one of the major causes of pure red cell aplasia, affecting the recovery of renal allograft function, and even leading to the injury or poor prognosis of renal allograft. To further standardize the diagnosis and treatment of HPV-B19 infection in kidney transplant recipients, Branch of Organ Transplantation of Chinese Medical Association and National Kidney Transplantation Quality Control Center jointly organized experts to formulate the clinical diagnosis and treatment specification for HPV-B19 infection after kidney transplantation from the perspectives of etiology, epidemiological characteristics, clinical manifestations, diagnosis, prevention, treatment, existing problems and prospects of HPV-B19, aiming to provide guidance for standardized prevention and treatment of HPV-B19 infection post-kidney transplantation in China.

表1 肾移植受者HPV-B19感染的主要危险因素
表2 HPV-B19感染相关的几种疾病
表3 肾移植受者HPV-B19感染的临床诊断
1
Lobbes H, Mahévas M, Alviset S, et al. Pure red cell aplasia in systemic lupus erythematosus, a nationwide retrospective cohort and review of the literature[J]. Rheumatology (Oxford), 2021, 61(1):355-366.
2
Rezahosseini O, Ekenberg C, Møller DL, et al. Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients[J]. J Infect Dis, 2021, 224(5):865-869.
3
Eid AJ, Ardura MI; AST Infectious Diseases Community of Practice. Human parvovirus B19 in solid organ transplantation: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice[J]. Clin Transplant, 2019, 33(9):e13535.
4
涂金鹏. 实体器官移植术后人微小病毒B19感染研究进展[J/CD]. 泌尿外科杂志(电子版), 2021, 13(2):15-18.
5
Cnc Garcia R, Leon LA. Human parvovirus B19: a review of clinical and epidemiological aspects in Brazil[J]. Future Microbiol, 2021, 16(1):37-50.
6
Ganaie SS, Qiu J. Recent advances in replication and infection of human parvovirus B19[J]. Front Cell Infect Microbiol, 2018, 8:166.
7
Brown KE, Hibbs JR, Gallinella G, et al. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen)[J]. N Engl J Med, 1994, 330(17):1192-1196.
8
Nouri M, Kamakifar P, Khodabandehlou N, et al. Association between parvovirus B19 and anemia in HIV-infected patients[J]. Med J Islam Repub Iran, 2019, 33:137.
9
段继惠,穆红,唐志琴,等. 肾移植受者感染人类细小病毒B19后对T淋巴细胞的影响[J]. 中华实验外科杂志2014, 31(4):902.
10
Sim JY, Chang LY, Chen JM, et al. Human parvovirus B19 infection in patients with or without underlying diseases[J]. J Microbiol Immunol Infect, 2019, 52(4): 534-541.
11
Ki CS, Kim IS, Kim JW, et al. Incidence and clinical significance of human parvovirus B19 infection in kidney transplant recipients[J]. Clin Transplant, 2005, 19(6):751-755.
12
Gosset C, Viglietti D, Hue K, et al. How many times can parvovirus B19-related anemia recur in solid organ transplant recipients?[J]. Transpl Infect Dis, 2012, 14(5):E64-E70.
13
张欢,肖霞,李玉明,等. 实体器官移植后细小病毒B19感染导致单纯红细胞再生障碍性贫血3例并文献复习[J]. 中华实验和临床病毒学杂志202034(5):543-546.
14
Altheaby A, Alotaibi M, Alajlan N, et al. Parvovirus B19 infection due to over immunosuppression in kidney transplant recipients: case reports and literature review[J]. Case Rep Transplant, 2021:7651488.
15
Porignaux R, Vuiblet V, Barbe C, et al. Frequent occurrence of parvovirus B19 DNAemia in the first year after kidney transplantation[J]. J Med Virol, 2013, 85(6):1115-1121.
16
Thongprayoon C, Khoury NJ, Bathini T, et al. Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: a meta-analysis[J]. Urol Ann, 2020, 12(3):241-247.
17
Mende M, Sockel K. Parvovirus B19 infection[J]. N Engl J Med, 2018, 379(24):2361.
18
Yu Y, Wei C, Lyu J, et al. Donor-derived human parvovirus B19 infection in kidney transplantation[J]. Front Cell Infect Microbiol, 2021, 11:753970.
19
Baek CH, Kim H, Yang WS, et al. Risk factors and long-term outcomes of parvovirus B19 infection in kidney transplant patients[J]. Transpl Infect Dis, 2017, 19(5): 10.1111/tid.12754.
20
Kooistra K, Mesman HJ, de Waal M, et al. Epidemiology of high-level parvovirus B19 viraemia among Dutch blood donors, 2003-2009[J]. Vox Sang, 2011, 100(3):261-266.
21
耿彦生,张印法. 血液、血制品与人类微小病毒B19的传播[J]. 疾病控制杂志2007, 11(5):516-519.
22
Zhang W, Ke L, Changqing L, et al. Parvovirus B19V DNA contamination in Chinese plasma and plasma derivatives[J]. J Transl Med, 2012, 10:194.
23
Barzon L, Murer L, Pacenti M, et al. Detection of viral DNA in kidney graft preservation and washing solutions is predictive of posttransplant infections in pediatric recipients[J]. J Infect Dis, 2009, 200(9):1425-1433.
24
熊睿,丁利民,柳祝菁,等. 肾移植后细小病毒B19感染所致贫血的诊疗策略[J/CD]. 实用器官移植电子杂志2021, 9(3):249-252.
25
Kauffmann M, Bobot M, Daniel L, et al. Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy[J]. BMC Nephrol, 2020, 21(1):260.
26
Barzon L, Murer L, Pacenti M, et al. Investigation of intrarenal viral infections in kidney transplant recipients unveils an association between parvovirus B19 and chronic allograft injury[J]. J Infect Dis, 2009, 199(3):372-380.
27
Abdelrahman D, Al-Sadeq DW, Smatti MK, et al. Prevalence and phylogenetic analysis of parvovirus (B19V) among blood donors with different nationalities residing in Qatar[J]. Viruses, 2021, 13(4):540.
28
胡娜娜,许书添,董建华,等. 肾移植术后人细小病毒B19感染[J]. 肾脏病与透析肾移植杂志201827(6):589-593.
29
Das P, Chatterjee K, Chattopadhyay NR, et al. Evolutionary aspects of parvovirus B-19V associated diseases and their pathogenesis patterns with an emphasis on vaccine development[J]. Virusdisease, 2019, 30(1): 32-42.
30
Rosado-Canto R, Carrillo-Pérez DL, Jiménez JV, et al. Treatment strategies and outcome of parvovirus B19 infection in kidney transplant recipients: a case series and literature review of 128 patients[J]. Rev Invest Clin, 2019, 71(4):265-274.
31
Hazebroek MR, Henkens MTHM, Raafs AG, et al. Intravenous immunoglobulin therapy in adult patients with idiopathic chronic cardiomyopathy and cardiac parvovirus B19 persistence: a prospective, double-blind, randomized, placebo-controlled clinical trial[J]. Eur J Heart Fail, 2021, 23(2):302-309.
32
Wasserman RL. Immunoglobulin replacement for primary immunodeficiency: indications for initiating and continuing treatment[J]. Allergy Asthma Proc, 2021, 42(6):489-494.
33
Crabol Y, Terrier B, Rozenberg F, et al. Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus B19 infection: a retrospective study of 10 patients and review of the literature[J]. Clin Infect Dis, 2013, 56(7):968-977.
34
张晓伟,张雷,赵闻雨,等. 肾移植术后微小病毒B19感染22例临床治疗经验[J]. 中华器官移植杂志2019, 40(6):323-327.
35
Bua G, Conti I, Manaresi E, et al. Antiviral activity of brincidofovir on parvovirus B19[J]. Antiviral Res, 2019, 162:22-29.
36
Manaresi E, Gallinella G. Advances in the development of antiviral strategies against parvovirus B19[J]. Viruses, 2019, 11(7):659.
37
Baral A, Poudel B, Agrawal RK, et al. Pure red cell aplasia caused by parvo B19 virus in a kidney transplant recipient[J]. JNMA J Nepal Med Assoc, 2012, 52(186):75-78.
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