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中华移植杂志(电子版) ›› 2024, Vol. 18 ›› Issue (05) : 310 -314. doi: 10.3877/cma.j.issn.1674-3903.2024.05.010

综述

肝移植术后脾功能亢进转归及治疗研究进展
贺健1, 张骊1, 王洪海1, 蒋文涛1,()   
  1. 1.300392 天津,天津市第一中心医院肝移植科 南开大学移植医学研究院 天津市器官移植重点实验室 天津市肝癌分子诊断与治疗重点实验室
  • 收稿日期:2024-06-13 出版日期:2024-10-25
  • 通信作者: 蒋文涛
  • 基金资助:
    国家自然科学基金(81870444)天津市卫生健康科技项目(TJWJ2022QN032)天津市卫生健康委员会重点学科专项(TJWJ2022XK016)天津市第一中心医院青年创新人才项目

Research progress on the prognosis and treatment of hypersplenism after liver transplantation

Jian He1, Li Zhang1, Honghai Wang1, Wentao Jiang1,()   

  1. 1.Department of Liver Transplantation, Tianjin First Central Hospital, Nankai University Institute of Transplantation Medicine, Tianjin Key Laboratory of Organ Transplantation, Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer,Tianjin 300392, China
  • Received:2024-06-13 Published:2024-10-25
  • Corresponding author: Wentao Jiang
引用本文:

贺健, 张骊, 王洪海, 蒋文涛. 肝移植术后脾功能亢进转归及治疗研究进展[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 310-314.

Jian He, Li Zhang, Honghai Wang, Wentao Jiang. Research progress on the prognosis and treatment of hypersplenism after liver transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(05): 310-314.

脾功能亢进是肝硬化门静脉高压患者的常见并发症,主要表现为脾大和血细胞减少。由于病情严重程度不一,脾功能亢进患者在肝移植术后的转归存在差异;同时,在肝移植不同阶段,脾功能亢进的治疗方法和原则也不尽相同。本文综述肝硬化脾功能亢进现状、肝移植术后脾功能亢进的变化及其潜在机制和治疗方法,以期为肝硬化脾功能亢进的诊治提供参考。

Hypersplenism is a common complication in cirrhotic patients with portal hypertension. The main manifestations are splenomegaly and hemocytopenia. The outcome of patients with hypersplenism after liver transplantation is different due to the severity of the disease. At the same time, the treatment methods and principles of hypersplenism are different in different stages during liver transplantation. This article reviews the status quo of hypersplenism in liver cirrhosis, the changes of hypersplenism after liver transplantation, its potential mechanism and treatment, in order to provide reference for the diagnosis and treatment of hypersplenism resulted from cirrhosis.

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