系统分析国内外异种肝移植(XLT)相关研究文献，深入探讨该领域的热点问题。

利用CiteSpace软件对2012年1月1日至2023年12月31日期间Web of Science核心数据库、中国知网和万方数据库中收录的XLT主题文献进行详尽的可视化分析。分析维度包括文献年发表量、发文作者、发文国家/地区、发文机构及关键词等。

本次分析共纳入XLT主题英文文献283篇、中文文献38篇。在此期间，中文文献发文量总体平稳，英文文献发表整体呈下降态势。中文文献发文量排名前三位的作者依次是陶开山(11篇)、窦科峰(10篇)和李霄(10篇)；英文文献发文量排名前三位的作者依次是Ayares David(13篇)、Burlak Christopher(11篇)、和A Joseph Tector(9篇)。中文文献发文量排名前三位的机构依次是空军军医大学西京医院(9篇)、西安交通大学第一附属医院(8篇)和中国农业科学院(4篇)；英文文献发文量排名前三位的机构依次是美国哈佛大学(24篇)、美国麻省总医院(17篇)和西班牙阿里沙卡圣母大学临床医院(17篇)。国内外相关核心作者、核心机构之间的研究合作有进一步挖掘的潜力。共计37个国家和地区参与了XLT研究，文献发文量排名前三位的国家依次为美国(77篇)、中国(70篇)和韩国(32篇)。关键词主题聚类分析揭示，国内外XLT领域研究焦点主要集中在炎症、细胞治疗、实验模型、公众态度、免疫微环境调控、生物医学工程和临床应用7个主题群。关键词聚类时间线分析显示，国内外研究中免疫排斥、炎症、动物模型、细胞治疗和态度的相关研究成为热点方向，各研究热点之间紧密关联。

XLT研究意义重大，未来通过加强国内外作者合作、政策鼓励和资金分配倾斜等手段，有望进一步促进该领域的发展。

To systematically analyze the related literature of xenogeneic liver transplantation (XLT) at home and abroad, and to explore the hot issues in this field.

CiteSpace software was used to conduct a detailed visual analysis of XLT related literature included in the Web of Science core database, China National Knowledge Infrastructure (CNKI) and Wanfang database from January 1, 2012 to December 31, 2023. The analysis dimensions included annual publication volume, author, country/region, institution and key words.

A total of 283 English articles and 38 Chinese articles on XLT were included in this analysis. The analysis showed that during this period, the number of Chinese literature published was generally stable, while the number of English literature published showed an overall decline. The top three authors of Chinese literature were Tao Kaishan (11 articles), Dou Kefeng (10 articles) and Li Xiao (10 articles). The top three authors of English articles were Ayares David (13 articles), Burlak Christopher (11 articles), and A Joseph Tector (9 articles). The top three institutions in terms of the number of Chinese articles were Xijing Hospital of Air Force Medical University (9 articles), the First Affiliated Hospital of Xi 'an Jiaotong University (8 articles) and Chinese Academy of Agricultural Sciences (4 articles). The top three institutions in terms of the number of English articles were Harvard University (24 articles), Massachusetts General Hospital (17 articles) and Hospital Clinico Universitario Virgen de la Arrixaca (17 articles) in Spain. The research cooperation between relevant core authors and core institutions at home and abroad had the potential to be further explored. A total of 37 countries and regions participated in XLT research, and the top three countries in terms of the number of articles were the United States (77 articles), China (70 articles), and South Korea (32 articles). Keyword topic cluster analysis revealed that the research focus in the field of XLT at home and abroad mainly focused on seven theme groups: inflammation, cell therapy, experimental model, public attitude, immune microenvironment regulation, biomedical engineering and clinical application. Keyword cluster timeline analysis showed that the research related to immune rejection, inflammation, animal models, cell therapy and attitude had become hot topics in domestic and foreign research, and the research hotspots were closely related.

XLT research is of great significance, and it is expected to further promote the development of this field by strengthening the cooperation between domestic and foreign authors, policy encouragement and preferential funding allocation in the future.