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中华移植杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 252 -258. doi: 10.3877/cma.j.issn.1674-3903.2025.04.007

移植前沿

非HLA抗体分类及其在器官移植临床诊疗中的研究进展
朱兰1,(), 陈刚1, 蔡俊超2, 庆欣3, 吴建永4   
  1. 1430030 武汉,华中科技大学同济医学院附属同济医院器官移植研究所
    2215004 苏州,苏州才博医学研究所
    390502 美国,加州大学洛杉矶Harbor医学中心病理科
    4310003 杭州,浙江大学医学院附属第一医院肾脏病中心
  • 收稿日期:2024-07-10 出版日期:2025-08-25
  • 通信作者: 朱兰
  • 基金资助:
    湖北省科技厅高端外国专家项目(2024DJC015)

Classification of non-HLA antibodies and research progress in clinical diagnosis and treatment of organ transplantation

Lan Zhu1,(), Gang Chen1, Junchao Cai2, Xin Qing3, Jianyong Wu4   

  1. 1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    2Suzhou Caibo Medical Research Institute, Suzhou 215004, China
    3Department of Pathology, Harbor-UCLA Medical Center, University of California, Los Angeles 90502, USA
    4Kidney Disease Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2024-07-10 Published:2025-08-25
  • Corresponding author: Lan Zhu
引用本文:

朱兰, 陈刚, 蔡俊超, 庆欣, 吴建永. 非HLA抗体分类及其在器官移植临床诊疗中的研究进展[J/OL]. 中华移植杂志(电子版), 2025, 19(04): 252-258.

Lan Zhu, Gang Chen, Junchao Cai, Xin Qing, Jianyong Wu. Classification of non-HLA antibodies and research progress in clinical diagnosis and treatment of organ transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2025, 19(04): 252-258.

尽管已有众多临床研究发现非HLA抗体与移植物组织受损或失功有关,但只有极少数研究提供了非HLA抗体可导致移植物损伤的证据。本文根据非HLA抗体靶抗原是否具有多态性以及靶抗原在组织和细胞中的主要表达部位,对非HLA抗体进行分类,并根据其引起或参与抗体介导排斥反应的可能性,分别提出了临床应对措施。

Despite numerous clinical studies finding associations between non-HLA antibodies and graft tissue damage or dysfunction, only a limited number of studies have provided evidence that non-HLA antibodies can cause graft injury. This article categorizes non-HLA antibodies based on whether their target antigens are polymorphic and the primary expression sites of these antigens in tissues and cells. It also proposes clinical measures based on the likelihood of these antibodies causing or participating in antibody mediated rejection.

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