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中华移植杂志(电子版) ›› 2017, Vol. 11 ›› Issue (02) : 114 -118. doi: 10.3877/cma.j.issn.1674-3903.2017.02.012

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综述

肝移植术后肠道菌群失调的研究进展
王垒1, 彭贵主1,(), 叶啟发2   
  1. 1. 430071 武汉大学中南医院 武汉大学肝胆疾病研究院 武汉大学移植医学中心 移植医学湖北省重点实验室
    2. 430071 武汉大学中南医院 武汉大学肝胆疾病研究院 武汉大学移植医学中心 移植医学湖北省重点实验室;410013 长沙,中南大学湘雅三医院 卫生部移植医学工程技术研究中心
  • 收稿日期:2016-08-29 出版日期:2017-05-25
  • 通信作者: 彭贵主
  • 基金资助:
    国家自然科学基金新疆联合基金重点支持项目(U1403222); 武汉市科技局项目(20160601010033)

The progress of alteration of intestinal flora after liver transplantation

Lei Wang1, Guizhu Peng1,(), Qifa Ye2   

  1. 1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Disease of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
    2. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Disease of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China;Research Center of National Health Ministry on Transplantation Medicine and Technology, the Third Xiangya Hospital of Central South University, Changsha 410013, China
  • Received:2016-08-29 Published:2017-05-25
  • Corresponding author: Guizhu Peng
  • About author:
    Corresponding author: Peng Guizhu, Email:
引用本文:

王垒, 彭贵主, 叶啟发. 肝移植术后肠道菌群失调的研究进展[J]. 中华移植杂志(电子版), 2017, 11(02): 114-118.

Lei Wang, Guizhu Peng, Qifa Ye. The progress of alteration of intestinal flora after liver transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2017, 11(02): 114-118.

近年来,随着分子生物学技术的飞速发展,肠道微生物作为一个"器官"受到越来越广泛的关注。肠道微生物与机体免疫系统相互作用,共同维持机体的免疫稳态。肠道菌群失调可能是肝移植术后发生感染、排斥反应等并发症的重要原因。通过选择性去污、缺血预处理、益生菌和粪便菌群移植等手段干预肠道微生物可在一定程度上改善肝移植受者预后。

Recently, intestinal flora, as an organ, is being paid much more attention accompanied with rapid development of molecular biotechnology. Intestinal microbiota maintains the balance of immune state through interaction with immune system. Intestinal dysbacteriosis might be one of the reasons for complications after liver transplantation such as infection and rejection. Strategies such as selective digestive decontamination, ischemic preconditioning, probiotics and fecal microbiota transplantation can improve prognosis of liver transplantation.

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