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中华移植杂志(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 151 -155. doi: 10.3877/cma.j.issn.1674-3903.2019.02.016

所属专题： 文献；

综述

肺移植术后T细胞亚群研究进展
练巧燕1, 陈奥1, 巨春蓉1,†()   
  1. 1. 510120　广州医科大学附属第一医院　广州呼吸健康研究院　呼吸疾病国家重点实验室
  • 收稿日期:2019-01-07 出版日期:2019-05-25
  • 通信作者: 巨春蓉
  • 基金资助:
    呼吸疾病国家重点实验室青年自主课题(SKLRD-QN-201710); 广东省自然科学基金(2018A030313107); 广州呼吸健康研究院临床自主探索项目(2019GIRHZ04)

Progress on T lymphocyte subsets after lung transplantation

Qiaoyan Lian1, Ao Chen1, Chunrong Ju1,†()   

  1. 1. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
  • Received:2019-01-07 Published:2019-05-25
  • Corresponding author: Chunrong Ju
  • About author:
    Corresponding author: Ju Chunrong, Email:
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练巧燕, 陈奥, 巨春蓉. 肺移植术后T细胞亚群研究进展[J]. 中华移植杂志(电子版), 2019, 13(02): 151-155.

Qiaoyan Lian, Ao Chen, Chunrong Ju. Progress on T lymphocyte subsets after lung transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2019, 13(02): 151-155.

T细胞是肺移植术后免疫应答的主要效应细胞，其细胞亚群水平对肺移植受者机体免疫状态具有重要影响。本文综述CD4＋ T细胞、CD8＋ T细胞和调节性T细胞的免疫学机制及其与肺移植术后原发性移植肺功能障碍、排斥反应、免疫耐受和感染等的关系，同时探讨监测肺移植术后T细胞亚群的临床意义。

关键词: 肺移植, T细胞亚群, 调节性T细胞, 原发性移植肺功能障碍

T lymphocytes are the main effector cells of the immune response after lung transplantation. The level of lymphocyte subsets has an important influence on the immune status of recipients after lung transplantation. This article summarizes the immunological mechanisms of CD4+ T cells, CD8+ T cells and regulatory T cells, as well as their roles in primary graft dysfunction, acute rejection, chronic rejection, immune tolerance and infection after lung transplantation. Finally, we discuss the clinical significance of detecting T lymphocyte subsets after lung transplantation.

Key words: Lung transplantation, T lymphocyte subsets, Regulatory T cell, Primary graft dysfunction
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