切换至 "中华医学电子期刊资源库"

中华移植杂志(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 156 -160. doi: 10.3877/cma.j.issn.1674-3903.2019.02.017

所属专题: 文献

综述

体外膜肺氧合在器官移植领域中的应用进展
谢琴芬1, 彭传会2, 郑树森3,()   
  1. 1. 310000 杭州,树兰(杭州)医院肝胆胰外科
    2. 310003 杭州,浙江大学医学院附属第一医院肝胆胰外科
    3. 310000 杭州,树兰(杭州)医院肝胆胰外科;310003 杭州,浙江大学医学院附属第一医院肝胆胰外科
  • 收稿日期:2019-01-18 出版日期:2019-05-25
  • 通信作者: 郑树森
  • 基金资助:
    中国工程院咨询研究项目(2017-XZ-08)

Progress in the application of extracorporeal membrane oxygenation in organ transplantation

Qinfen Xie1, Chuanhui Peng2, Shusen Zheng3,()   

  1. 1. Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou)Hospital, Hangzhou 310000, China
    2. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    3. Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou)Hospital, Hangzhou 310000, China; Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
  • Received:2019-01-18 Published:2019-05-25
  • Corresponding author: Shusen Zheng
  • About author:
    Corresponding author: Zheng Shusen, Email:
引用本文:

谢琴芬, 彭传会, 郑树森. 体外膜肺氧合在器官移植领域中的应用进展[J]. 中华移植杂志(电子版), 2019, 13(02): 156-160.

Qinfen Xie, Chuanhui Peng, Shusen Zheng. Progress in the application of extracorporeal membrane oxygenation in organ transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2019, 13(02): 156-160.

体外膜肺氧合(ECMO)是一种能代替心肺功能、维持器官持续灌注的体外循环技术。近年来,因其出色的心肺支持功能,ECMO被越来越多地运用于器官移植领域,从器官捐献供者器官的保护,到器官移植受者移植前的安全过渡、移植中生命支持及移植后呼吸循环系统并发症的处理。ECMO在扩大供者来源、提高移植手术安全性和移植受者存活率方面发挥了重要作用。本文就ECMO在器官移植领域中的应用研究进展进行综述。

Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary bypass technology which can replace cardiopulmonary function and maintain organ perfusion. Owing to the excellent cardiopulmonary support function of ECMO, it has been widely used in the field of organ transplantation, including donor organs protection, security transition of organ transplant recipients before transplantation, life support during transplantation, and management of respiratory and circulatory systems related complcations after transplantation in recent years. ECMO plays an important role in expanding the donor pool, for example in improving the safety of organ transplant operation and the survival rate of recipients. This paper reviews the progress in the application of ECMO in organ transplantation.

1
中华医学会器官移植学分会,中国医师协会器官移植医师分会. 体外膜肺氧合在中国公民逝世后捐献供器官保护中的应用专家共识(2016版)[J/CD]. 中华移植杂志:电子版,2016, 10(3):107-111.
2
Sánchez-Fructuoso AI, Marques M, Prats D, et al. Victims of cardiac arrest occurring outside the hospital: a source of transplantable kidneys[J]. Ann Intern Med, 2006, 145(3): 157-164.
3
Fondevila C, Hessheimer AJ, Ruiz A, et al. Liver transplant using donors after unexpected cardiac death: novel preservation protocol and acceptance criteria[J]. Am J Transplant, 2007, 7(7): 1849-1855.
4
Jiménez-Galanes S, Meneu-Diaz MJ, Elola-Olaso AM, et al. Liver transplantation using uncontrolled non-heart-beating donors under normothermic extracorporeal membrane oxygenation[J]. Liver Transpl, 2009, 15(9): 1110-1118.
5
Farney AC, Hines MH, al-Geizawi S, et al. Lessons learned from a single center′s experience with 134 donation after cardiac death donor kidney transplants[J]. J Am Coll Surg, 2011, 212(4): 440-451; discussion 451-453.
6
Lee JH, Hong SY, Oh CK, et al. Kidney transplantation from a donor following cardiac death supported with extracorporeal membrane oxygenation[J]. J Korean Med Sci, 2012, 27(2): 115-119.
7
Fondevila C, Hessheimer AJ, Flores E, et al. Applicability and results of Maastricht type 2 donation after cardiac death liver transplantation[J]. Am J Transplant, 2012, 12(1): 162-170.
8
霍枫,李鹏,汪邵平. 体外膜肺氧合在心脏死亡器官捐献中的应用[J]. 中华消化外科杂志,2013, 12(9):648-651.
9
Hsieh CE, Lin HC, Tsui YC, et al. Extracorporeal membrane oxygenation support in potential organ donors for brain death determination[J]. Transplant Proc, 2011, 43(7): 2495-2498.
10
Yang HY, Lin CY, Tsai YT, et al. Experience of heart transplantation from hemodynamically unstable brain-dead donors with extracorporeal support[J]. Clin Transplant, 2012, 26(5): 792-796.
11
何洹,李鹏,屠伟峰. 体外膜肺氧合用于潜在心脏死亡供者的院间转运[J]. 中华器官移植杂志,2013, 34(12):737-739.
12
范晓礼,王彦峰,胡龙,等. 体外膜肺氧合辅助公民逝世后器官捐献供者的维护与器官获取[J]. 中华器官移植杂志,2014, 35(9):537-541.
13
刘军. 体外膜肺氧合对循环功能不稳定中国一类供体腹部器官功能的保护[D]. 桂林医学院,2016.
14
Bronchard R, Durand L, Legeai C, et al. Brain-Dead donors on extracorporeal membrane oxygenation[J]. Crit Care Med, 2017, 45(10): 1734-1741.
15
Miñambres E, Suberviola B, Dominguez-Gil B, et al. Improving the outcomes of organs obtained from controlled donation after circulatory death donors using abdominal normothermic regional perfusion[J]. Am J Transplant, 2017, 17(8): 2165-2172.
16
Assalino M, Majno P, Toso C, et al. In situ liver splitting under extracorporeal membrane oxygenation in brain-dead donor[J]. Am J Transplant, 2018, 18(1): 258-261.
17
Molina M, Guerrero-Ramos F, Fernández-Ruiz M, et al. Kidney transplant from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death[J]. Am J Transplant, 2018, 19(2): 434-447.
18
Pérez-Villares JM, Lara-Rosales R, Fernández-Carmona A, et al. Mobile ECMO team for controlled donation after circulatory death[J]. Am J Transplant, 2018, 18(5): 1293-1294.
19
DiRito JR, Hosgood SA, Tietjen GT, et al. The future of marginal kidney repair in the context of normothermic machine perfusion[J]. Am J Transplant, 2018, 18(10): 2400-2408.
20
Hayanga AJ, Du AL, Joubert K, et al. Mechanical ventilation and extracorporeal membrane oxygenation as a bridging strategy to lung transplantation: significant gains in survival[J]. Am J Transplant, 2018, 18(1): 125-135.
21
Ius F, Sommer W, Tudorache I, et al. Five-year experience with intraoperative extracorporeal membrane oxygenation in lung transplantation: Indications and midterm results[J]. J Heart Lung Transplant, 2016, 35(1): 49-58.
22
周敏,朱艳红,严洁,等. 肺移植术后原发性移植物功能丧失的预防和治疗[J]. 中华器官移植杂志,2012, 33(8):495-497.
23
韩杰,孟旭,贾一新,等. ECMO在临床心脏移植领域的应用[J]. 中华胸心血管外科杂志,2009, 25(2):112-114.
24
张海波,孟旭,韩杰,等. 改良ECMO代体外循环技术增加心脏移植边缘性供心应用[J]. 中华胸心血管外科杂志,2013, 29(11):660-662, 666.
25
杨柯佳,毛文君,陈静瑜. 体外膜肺氧合作为肺移植术前移植桥梁的研究进展[J]. 器官移植,2019, 10(2):202-205.
26
Stratta C, Lavezzo B, Ballaris MA, et al. Extracorporeal membrane oxygenation rescue therapy in a case of portopulmonary hypertension during liver transplantation: a case report[J]. Transplant Proc, 2013, 45(7): 2774-2775.
27
Park YH, Hwang S, Park HW, et al. Effect of pulmonary support using extracorporeal membrane oxygenation for adult liver transplant recipients with respiratory failure[J]. Transplant Proc, 2012, 44(3): 757-761.
28
Landsman IS, Karsanac CJ. Case report: pediatric liver retransplantation on an extracorporeal membrane oxygenation-dependent child[J]. Anesth Analg, 2010, 111(5): 1275-1278.
29
Eudailey KW, Yi SY, Mongero LB, et al. Trans-diaphragmatic left ventricular venting during peripheral venous-arterial extracorporeal membrane oxygenation[J]. Perfusion, 2015, 30(8): 701-703.
30
Sun X, Qiu W, Chen Y, et al. Utilization of extracorporeal membrane oxygenation for a severe cardiocirculatory dysfunction recipient in liver transplantation: A case report[J]. Medicine (Baltimore), 2018, 97(37): e12407.
31
Wu YS, Lin NC, Chen IM, et al. Extracorporeal membrane oxygenation as treatment for acute respiratory failure and subsequent pneumothorax caused by Pneumocystis jirovecii pneumonia in a kidney transplant recipient[J]. Transpl Infect Dis, 2013, 15(1): E5-E8.
32
Baek JK, Lee JS, Kim TH, et al. Four-year experience with extracorporeal membrane oxygenation for kidney transplant patients with severe refractory cardiopulmonary insufficiency[J]. Transplant Proc, 2016, 48(6): 2080-2083.
33
袁润强,宫满成,董文静,等. 体外膜肺氧合对非可控型心脏死亡器官捐献供肾的保护作用[J]. 器官移植,2018, 9(1):74-78.
34
Dalle Ave AL, Gardiner D, Shaw DM. The ethics of extracorporeal membrane oxygenation in brain-dead potential organ donors[J]. Transpl Int, 2016, 29(5): 612-618.
35
Dalle Ave AL, Shaw DM, Bernat JL. Ethical issues in the use of extracorporeal membrane oxygenation in controlled donation after circulatory determination of death[J]. Am J Transplant, 2016, 16(8): 2293-2299.
36
Dalle Ave AL, Shaw DM, Gardiner D. Extracorporeal membrane oxygenation (ECMO) assisted cardiopulmonary resuscitation or uncontrolled donation after the circulatory determination of death following out-of-hospital refractory cardiac arrest-An ethical analysis of an unresolved clinical dilemma[J]. Resuscitation, 2016, 108: 87-94.
37
蓝倩,李壮江,孙煦勇,等. 体外膜肺氧合应用在捐献器官移植中的伦理学意义[J]. 中国医学伦理学,2015, 28(5):741-744.
[1] 中华医学会器官移植学分会, 中国医师协会器官移植医师分会, 上海医药行业协会. 中国肝、肾移植受者霉酚酸类药物应用专家共识(2023版)[J]. 中华移植杂志(电子版), 2023, 17(05): 257-272.
[2] 江文诗, 何湘湘. 全球及我国器官捐献发展特征分析与学科建设[J]. 中华移植杂志(电子版), 2023, 17(05): 280-286.
[3] 吴建永. 单中心2 000例心脏死亡器官捐献肾移植发展与创新[J]. 中华移植杂志(电子版), 2023, 17(04): 0-.
[4] 巨春蓉, 何建行, 钟南山. 咪唑立宾在器官移植领域的应用及展望[J]. 中华移植杂志(电子版), 2023, 17(04): 227-231.
[5] 叶啟发, 兰佳男. 中国人体器官捐献与异种移植[J]. 中华移植杂志(电子版), 2023, 17(04): 221-226.
[6] 中国康复医学会器官移植康复专业委员会. 成人实体器官移植后糖尿病管理专家共识[J]. 中华移植杂志(电子版), 2023, 17(04): 205-220.
[7] 刘剑戎, 范明明, 郭煜. 器官捐献者转介时的临床特征分析[J]. 中华移植杂志(电子版), 2023, 17(03): 129-133.
[8] 杨锦然, 李新长, 何小平, 傅俊, 龙成美, 陈志铭. 不破坏膈肌式肝肾联合获取术总结分析[J]. 中华移植杂志(电子版), 2023, 17(03): 146-151.
[9] 艾紫叶, 李玲, 何重香, 黄伟, 叶啟发. 猪器官异种移植研究进展[J]. 中华移植杂志(电子版), 2023, 17(03): 186-191.
[10] 陈琦, 郭嘉瑜, 陈忠宝, 马枭雄, 王天宇, 邹寄林, 张龙, 蔡治涛, 邱涛, 周江桥. 新型冠状病毒感染流行下我国器官捐献者筛选规则是否应时而变?[J]. 中华移植杂志(电子版), 2023, 17(02): 82-88.
[11] 王璐, 施辉波, 曾梦君, 李小勤, 张波, 徐晶, 吴星, 蒋继贫, 陈知水. 人体捐献器官获取全流程远程交互系统的设计与应用[J]. 中华移植杂志(电子版), 2023, 17(02): 89-93.
[12] 白玲, 陈国振, 祝锦江, 刘海平, 丁晨光, 王华. 专职器官获取护士工作的初步探索[J]. 中华移植杂志(电子版), 2023, 17(02): 94-97.
[13] 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组, 华南劈离式肝移植联盟. 劈离式肝移植血管分割与重建中国专家共识[J]. 中华肝脏外科手术学电子杂志, 2023, 12(02): 167-172.
[14] 方可, 笪欢欢, 汪君, 孙瑞祥, 王涛, 李阳, 江海娇, 鲁卫华. ECMO联合肾上腺切除救治妊娠期嗜铬细胞瘤并儿茶酚胺心肌病一例并文献回顾[J]. 中华重症医学电子杂志, 2023, 09(03): 304-310.
[15] 高学慧, 邹晓静, 杨小博, 尚游. 甲磺酸萘莫司他在重症患者CRRT与ECMO中抗凝应用的研究进展[J]. 中华重症医学电子杂志, 2023, 09(02): 210-216.
阅读次数
全文


摘要