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中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (01) : 45 -48. doi: 10.3877/cma.j.issn.1674-3903.2021.01.010

所属专题: 经典病例 文献

经验交流

B细胞淋巴瘤/白血病-2抑制剂联合阿扎胞苷治疗急性髓系白血病异基因造血干细胞移植后复发两例
张勇1, 周合冰1,()   
  1. 1. 101149 北京,首都医科大学附属北京潞河医院血液科
  • 收稿日期:2020-11-12 出版日期:2021-02-25
  • 通信作者: 周合冰

B cell lymphoma/leukemia-2 inhibitor plus azacytidine regimen for two cases of relapse acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation

Yong Zhang1, Hebing Zhou1,()   

  1. 1. Department of Hematology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China
  • Received:2020-11-12 Published:2021-02-25
  • Corresponding author: Hebing Zhou
引用本文:

张勇, 周合冰. B细胞淋巴瘤/白血病-2抑制剂联合阿扎胞苷治疗急性髓系白血病异基因造血干细胞移植后复发两例[J]. 中华移植杂志(电子版), 2021, 15(01): 45-48.

Yong Zhang, Hebing Zhou. B cell lymphoma/leukemia-2 inhibitor plus azacytidine regimen for two cases of relapse acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(01): 45-48.

1
De Lima M, Porter DL, Battiwalla M, et al. Proceedings from the National Cancer Institute′s Second International Workshop on the biology, prevention, and treatment of relapse after hematopoietic stem cell transplantation: part Ⅲ. Prevention and treatment of relapse after allogeneic transplantation[J]. Biol Blood Marrow Transplant, 2014, 20(1): 4-13.
2
Rautenberg C, Germing U, Haas R, et al. Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: prevention, detection, and treatment[J]. Int J Mol Sci, 2019, 20(1): 228.
3
Schmid C, de Wreede LC, van Biezen A, et al. Outcome after relapse of myelodysplastic syndrome and secondary acute myeloid leukemia following allogeneic stem cell transplantation: a retrospective registry analysis on 698 patients by the Chronic Malignancies Working Party of the European Society of Blood and Marrow Transplantation[J]. Haematologica, 2018, 103(2): 237-245.
4
Schmid C, Labopin M, Nagler A, et al. Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation[J]. Blood, 2012,119(6): 1599-1606.
5
Bhagat TD, Chen S, Bartenstein M, et al. Epigenetically aberrant stroma in MDS propagates disease via Wnt/β-Catenin activation[J]. Cancer Res, 2017, 77(18): 4846-4857.
6
Lee CJ, Savani BN, Mohty M, et al. Post-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation[J]. Bone Marrow Transplant, 2019, 54(4): 519-530.
7
Orti G, Barba P, Fox L, et al. Donor lymphocyte infusions in AML and MDS: Enhancing the graft-versus-leukemia effect[J]. Exp Hematol, 2017, 48:1-11.
8
Schroeder T, Rachlis E, Bug G, et al. Treatment of acute myeloid leukemia or myelodysplastic syndrome relapse after allogeneic stem cell transplantation with azacitidine and donor lymphocyte infusions-a retrospective multicenter analysis from the German Cooperative Transplant Study Group[J]. Biol Blood Marrow Transplant, 2015, 21(4):653-660.
9
Schroeder T, Fröbel J, Cadeddu RP, et al. Salvage therapy with azacitidine increases regulatory T cells in peripheral blood of patients with AML or MDS and early relapse after allogeneic blood stem cell transplantation[J]. Leukemia, 2013, 27(9): 1910-1913.
10
Schroeder T, Rautenberg C, Haas R, et al. Hypomethylating agents after allogeneic blood stem cell transplantation[J]. Stem Cell Investig, 2016, 3:84.
11
DiNardo CD, Stein EM, de Botton S, et al. Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML[J]. N Engl J Med, 2018, 378(25): 2386-2398.
12
Stein EM, DiNardo CD, Pollyea DA, et al. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia[J]. Blood, 2017, 130(6): 722-731.
13
Stone RM, Mandrekar SJ, Sanford BL, et al. Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation[J]. N Engl J Med, 2017, 377(5): 454-464.
14
DiNardo CD, Pratz K, Pullarkat V, et al. Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia[J]. Blood, 2019, 133(1):7-17.
15
DiNardo CD, Rausch CR, Benton C, et al. Clinical experience with the BCL2-inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies[J]. Am J Hematol, 2018, 93(3):401-407.
16
Pan R, Hogdal LJ, Benito JM, et al. Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia[J]. Cancer Discov, 2014,4(3):362-375.
17
Tsao T, Shi Y, Kornblau S, et al. Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells[J]. Ann Hematol, 2012,91(12):1861-1870.
18
Bogenberger JM, Delman D, Hansen N, et al. Ex vivo activity of BCL-2 family inhibitors ABT-199 and ABT-737 combined with 5-azacytidine in myeloid malignancies[J]. Leuk Lymphoma, 2015,56(1):226-229.
19
Ram R, Amit O, Zuckerman T, et al. Venetoclax in patients with acute myeloid leukemia refractory to hypomethylating agents-a multicenter historical prospective study[J]. Ann Hematol, 2019,98(8):1927-1932.
20
Byrne M, Danielson N, Sengsayadeth S, et al. The use of venetoclax-based salvage therapy for post-hematopoietic cell transplantation relapse of acute myeloid leukemia [J]. Am J Hematol, 2020, 95(9):1006-1014.
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