切换至 "中华医学电子期刊资源库"

中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 298 -302. doi: 10.3877/cma.j.issn.1674-3903.2021.05.009

综述

肝肺联合移植临床研究进展
赵晋1, 陈静瑜2,()   
  1. 1. 214023 南京医科大学附属无锡人民医院肺移植中心
    2. 214023 南京医科大学附属无锡人民医院肺移植中心;310009 杭州,浙江大学医学院附属第二医院肺移植科
  • 收稿日期:2021-04-15 出版日期:2021-10-25
  • 通信作者: 陈静瑜
  • 基金资助:
    江苏省医学杰出人才计划(JCRCB2016003)

Clinical research progress of combined liver and lung transplantation

Jin Zhao1, Jingyu Chen2,()   

  1. 1. Lung Transplant Center, Wuxi People′s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China
    2. Lung Transplant Center, Wuxi People′s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China; Department of Lung Transplantation, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2021-04-15 Published:2021-10-25
  • Corresponding author: Jingyu Chen
引用本文:

赵晋, 陈静瑜. 肝肺联合移植临床研究进展[J/OL]. 中华移植杂志(电子版), 2021, 15(05): 298-302.

Jin Zhao, Jingyu Chen. Clinical research progress of combined liver and lung transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 298-302.

当患者合并终末期肝病和终末期肺病且预估单器官移植无法存活时,肝肺联合移植(CLLT)是目前唯一可行的治疗方法。由于手术难度较高及供器官短缺,世界范围内仅少数移植中心报道过相关案例。本文回顾当前CLLT的相关文献,综述其适应证、术式选择、并发症及预后等。

The combined liver-lung transplantation (CLLT) is performed in patients with dual-organ failure in whom survival is not expected with single-organ transplantation alone. Due to the difficulty of the operation and the scarcity of donated organs, only a few transplant centers worldwide have reported relevant cases. This review evaluates the existing literature regarding CLLT, describing the indication, operation choosing, complications, and prognosis.

表1 肝肺联合移植适应证[2]
1
Zhang T, Price MB, Bravo N, et al. Combined lung-liver and delayed kidney transplantation for cystic fibrosis clinical approach and outcome: A case report[J]. Transplant Proc, 2020, 52(9): 2824-2826.
2
Han JL, Beal EW, Mumtaz K, et al. Combined liver-lung transplantation: Indications, outcomes, current experience and ethical issues[J]. Transplant Rev (Orlando), 2019, 33(2):99-106.
3
Adams B, Chiem D, Wang C, et al. Combined bilateral lung-liver transplantation complicated by intraoperative right ventricular dysfunction and postoperative hepatic artery thrombosis[J]. J Cardiothorac Vasc Anesth, 2013, 27(6): 1343-1346.
4
Chryssostalis A, Hubert D, Coste J, et al. Liver disease in adult patients with cystic fibrosis: a frequent and independent prognostic factor associated with death or lung transplantation[J]. J Hepatol, 2011, 55(6): 1377-1382.
5
Couetil JP, Houssin DP, Soubrane O, et al. Combined lung and liver transplantation in patients with cystic fibrosis. A 4 1/2-year experience[J]. J Thorac Cardiovasc Surg, 1995, 110(5): 1415-1422.
6
Debray D, Kelly D, Houwen R, et al. Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease[J]. J Cyst Fibros, 2011, 10 Suppl 2: S29-S36.
7
Christie JD, Bavaria JE, Palevsky HI, et al. Primary graft failure following lung transplantation[J]. Chest, 1998, 114(1): 51-60.
8
Desai CS, Gruessner A, Habib S, et al. Survival of cystic fibrosis patients undergoing liver and liver-lung transplantations[J]. Transplant Proc, 2013, 45(1): 290-292.
9
Freischlag KW, Messina J, Ezekian B, et al. Single-center long-term analysis of combined liver-lung transplant outcomes[J]. Transplant Direct, 2018, 4(5): e349.
10
Grannas G, Neipp M, Hoeper MM, et al. Indications for and outcomes after combined lung and liver transplantation: a single-center experience on 13 consecutive cases[J]. Transplantation, 2008, 85(4): 524-531.
11
Barshes NR, DiBardino DJ, McKenzie ED, et al. Combined lung and liver transplantation: the United States experience[J]. Transplantation, 2005, 80(9): 1161-1167.
12
Pirenne J, Verleden G, Nevens F, et al. Combined liver and (heart-) lung transplantation in liver transplant candidates with refractory portopulmonary hypertension[J]. Transplantation, 2002, 73(1): 140-142.
13
Yi SG, Burroughs SG, Loebe M, et al. Combined lung and liver transplantation: analysis of a single-center experience[J]. Liver Transpl, 2014, 20(1): 46-53.
14
Gadre S, Turowski J, Budev M. Overview of lung transplantation, heart-lung transplantation, liver-lung transplantation, and combined hematopoietic stem cell transplantation and lung transplantation[J]. Clin Chest Med, 2017, 38(4):623-640.
15
Weill D, Benden C, Corris PA, et al. A consensus document for the selection of lung transplant candidates: 2014-an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation[J]. J Heart Lung Transplant, 2015, 34(1): 1-15.
16
Scheiermann P, Czerner S, Kaspar M, et al. Combined lung and liver transplantation with extracorporeal membrane oxygenation instead of cardiopulmonary bypass[J]. J Cardiothorac Vasc Anesth, 2016, 30(2): 437-442.
17
Machuca TN, Collaud S, Mercier O, et al. Outcomes of intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation[J]. J Thorac Cardiovasc Surg, 2015, 149(4): 1152-1157.
18
Couetil JP, Soubrane O, Houssin DP, et al. Combined heart-lung-liver, double lung-liver, and isolated liver transplantation for cystic fibrosis in children[J]. Transpl Int, 1997, 10(1): 33-39.
19
Van De Wauwer C, Verschuuren EA, Nossent GD, et al. A staged approach for a lung-liver transplant patient using ex vivo reconditioned lungs first followed by an urgent liver transplantation[J]. Transpl Int, 2015, 28(1): 129-133.
20
Grimm JC, Valero V 3rd, Kilic A, et al. Association between prolonged graft ischemia and primary graft failure or survival following lung transplantation[J]. JAMA Surg, 2015, 150(6): 547-553.
21
Yeung JC, Krueger T, Yasufuku K, et al. Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study[J]. Lancet Respir Med, 2017, 5(2): 119-124.
22
Salman J, Grannas G, Ius F, et al. The liver-first approach for combined lung and liver transplantation[J]. Eur J Cardiothorac Surg, 2018, 54(6):1122-1127.
23
Ceulemans LJ, Monbaliu D, Verslype C, et al. Combined liver and lung transplantation with extended normothermic lung preservation in a patient with end-stage emphysema complicated by drug-induced acute liver failure[J]. Am J Transplant, 201414(10): 2412-2416.
24
Rana A, Robles S, Russo MJ, et al. The combined organ effect: protection against rejection?[J]. Ann Surg, 2008, 248(5): 871-879.
25
Olausson M, Mjörnstedt L, Nordén G, et al. Successful combined partial auxiliary liver and kidney transplantation in highly sensitized cross-match positive recipients[J]. Am J Transplant, 2007, 7(1): 130-136.
26
Ceulemans LJ, Strypstein S, Neyrinck A, et al. Combined liver-thoracic transplantation: single-center experience with introduction of the 'liver-first’ principle[J]. Transpl Int, 2016, 29(6): 715-726.
27
Ceulemans LJ, Vos R, Neyrinck A, et al. Liver-first versus lung-first: a new dilemma in combined organ transplantation[J]. Transpl Int, 2018, 31(2): 230-231.
28
Hadjiliadis D, Steele MP, Chaparro C, et al. Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria[J]. J Heart Lung Transplant, 2007, 26(8): 834-838.
29
Husain S, Sole A, Alexander BD, et al. The 2015 International Society for Heart and Lung Transplantation Guidelines for the management of fungal infections in mechanical circulatory support and cardiothoracic organ transplant recipients: Executive summary[J]. J Heart Lung Transplant, 2016, 35(3):261-282.
30
Fishman JA. Infection in organ transplantation[J]. Am J Transplant, 2017, 17(4): 856-879.
31
Scouras NE, Matsusaki T, Boucek CD, et al. Portopulmonary hypertension as an indication for combined heart, lung, and liver or lung and liver transplantation: literature review and case presentation[J]. Liver Transpl, 2011, 17(2): 137-143.
32
Corno V, Dezza MC, Lucianetti A, et al. Combined double lung-liver transplantation for cystic fibrosis without cardio-pulmonary by-pass[J]. Am J Transplant, 2007, 7(10): 2433-2438.
33
Le Rond S, Le Maoult J, Créput C, et al. Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients[J]. Eur J Immunol, 2004, 34(3): 649-660.
34
Bhama JK, Pilewski JM, Zaldonis D, et al. Does simultaneous lung-liver transplantation provide an immunologic advantage compared with isolated lung transplantation?[J]. J Thorac Cardiovasc Surg, 2011, 141(5): e36-e38.
35
Faro A, Shepherd R, Huddleston CB, et al. Lower incidence of bronchiolitis obliterans in pediatric liver-lung transplant recipients with cystic fibrosis[J]. Transplantation, 2007, 83(11): 1435-1439.
36
Crispe IN. Immune tolerance in liver disease[J]. Hepatology, 2014, 60(6): 2109-2117.
37
Arnon R, Annunziato RA, Miloh T, et al. Liver and combined lung and liver transplantation for cystic fibrosis: analysis of the UNOS database[J]. Pediatr Transplant, 2011, 15(3): 254-264.
[1] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[2] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[3] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[4] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[5] 李伟, 宋子健, 赖衍成, 周睿, 吴涵, 邓龙昕, 陈锐. 人工智能应用于前列腺癌患者预后预测的研究现状及展望[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 541-546.
[6] 陈樽, 王平, 金华, 周美玲, 李青青, 黄永刚. 肌肉减少症预测结直肠癌术后切口疝发生的应用研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 639-644.
[7] 关小玲, 周文营, 陈洪平. PTAAR在乙肝相关慢加急性肝衰竭患者短期预后中的预测价值[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 841-845.
[8] 张润锦, 阳盼, 林燕斯, 刘尊龙, 刘建平, 金小岩. EB病毒相关胆管癌伴多发转移一例及国内文献复习[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 865-869.
[9] 陈晓鹏, 王佳妮, 练庆海, 杨九妹. 肝细胞癌VOPP1表达及其与预后的关系[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 876-882.
[10] 刘郁, 段绍斌, 丁志翔, 史志涛. miR-34a-5p 在结肠癌患者的表达及其与临床特征及预后的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 485-490.
[11] 陈倩倩, 袁晨, 刘基, 尹婷婷. 多层螺旋CT 参数、癌胚抗原、错配修复基因及病理指标对结直肠癌预后的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 507-511.
[12] 曾明芬, 王艳. 急性胰腺炎合并脂肪肝患者CT 与彩色多普勒超声诊断参数与其病情和预后的关联性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 531-535.
[13] 沈炎, 张俊峰, 唐春芳. 预后营养指数结合血清降钙素原、胱抑素C及视黄醇结合蛋白对急性胰腺炎并发急性肾损伤的预测价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 536-540.
[14] 王景明, 王磊, 许小多, 邢文强, 张兆岩, 黄伟敏. 腰椎椎旁肌的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 846-852.
[15] 郭曌蓉, 王歆光, 刘毅强, 何英剑, 王立泽, 杨飏, 汪星, 曹威, 谷重山, 范铁, 李金锋, 范照青. 不同亚型乳腺叶状肿瘤的临床病理特征及预后危险因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 524-532.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?