切换至 "中华医学电子期刊资源库"

中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 302 -306. doi: 10.3877/cma.j.issn.1674-3903.2021.05.010

综述

乙型肝炎肝移植术后新型核苷(酸)类似物的应用研究进展
翟慧敏1, 解曼1, 孔心涓1, 饶伟2,()   
  1. 1. 266000 青岛大学附属医院消化内科
    2. 266000 青岛大学附属医院器官移植中心 肝脏病中心 青岛大学移植医学研究所
  • 收稿日期:2021-04-02 出版日期:2021-10-25
  • 通信作者: 饶伟
  • 基金资助:
    青岛大学医学部"临床医学+X"科研课题(2017223)

Application progression of new nucleos(t)ide analogues in hepatitis B related liver transplantation

Huimin Zhai1, Man Xie1, Xinjuan Kong1, Wei Rao2,()   

  1. 1. Department of Gastroenterology, Qingdao University, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
    2. Center for Organ Transplantation, Liver Disease Center, Institute of Transplantation Science, Qingdao University, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2021-04-02 Published:2021-10-25
  • Corresponding author: Wei Rao
引用本文:

翟慧敏, 解曼, 孔心涓, 饶伟. 乙型肝炎肝移植术后新型核苷(酸)类似物的应用研究进展[J/OL]. 中华移植杂志(电子版), 2021, 15(05): 302-306.

Huimin Zhai, Man Xie, Xinjuan Kong, Wei Rao. Application progression of new nucleos(t)ide analogues in hepatitis B related liver transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 302-306.

乙型肝炎复发是乙型肝炎肝移植受者术后面临的常见问题之一。近年来,核苷(酸)类似物(NAs)的应用极大地降低了肝移植术后乙型肝炎复发率,但其长期应用也带来了诸如HBV耐药及肾功能损伤等弊端。富马酸替诺福韦酯(TDF)和富马酸丙酚替诺福韦(TAF)均属于治疗乙型肝炎的低耐药NAs,其在肝移植领域的临床应用显示出良好的疗效和耐受性,尤其是在单一NAs预防肝移植术后乙型肝炎复发方面,具有较好的应用前景。本文对TDF和TAF等新型NAs在乙型肝炎肝移植术后的最新应用进展作一综述。

Hepatitis B virus (HBV) reactivation is one of the common problems faced by HBV-related recipients after liver transplantation. Recently, the application of nucleos(t)ide analogues (NAs) has greatly reduced the recurrence rate of HBV after liver transplantation, and long-term medication has also brought many disadvantages, such as drug resistance, kidney damage. Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide fumarate (TAF) are both high genetic barrier NAs, and clinical applications show that they have good efficacy and tolerability, especially NAs monoprophylaxis have a good application prospect against HBV reactivation after liver transplantation. This article reviews the latest application progress of TDF and TAF after liver transplantation.

1
WHO. Global hepatitis report, 2017[EB/OL]. (2019-11-06)[2021-03-31].

URL    
2
王贵强,王福生,庄辉,等. 慢性乙型肝炎防治指南(2019年版)[J]. 临床肝胆病杂志2019, 35(12):2648-2669.
3
Pfitzmann R, Nussler NC, Hippler-Benscheidt M, et al. Long-term results after liver transplantation[J]. Transpl Int, 2008, 21(3):234-246.
4
Todo S, Demetris AJ, Van Thiel D, et al. Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease[J]. Hepatology, 1991, 13(4):619-626.
5
O′Grady JG, Smith HM, Davies SE, et al. Hepatitis B virus reinfection after orthotopic liver transplantation. Serological and clinical implications[J]. J Hepatol, 1992, 14(1):104-111.
6
Lake JR, Wright TL. Liver transplantation for patients with hepatitis B: What have we learned from our results?[J]. Hepatology, 1991, 13(4):796-799.
7
Terrault NA, Bzowej NH, Chang KM, et al. AASLD guidelines for treatment of chronic hepatitis B[J]. Hepatology, 2016, 63(1):261-283.
8
Lok AS, McMahon BJ, Brown RS, et al. Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis[J]. Hepatology, 2016, 63(1):284-306.
9
Peng CY, Chien RN, Liaw YF. Hepatitis B virus-related decompensated liver cirrhosis: benefits of antiviral therapy[J]. J Hepatol, 2012, 57(2):442-450.
10
Singal AK, Fontana RJ. Meta-analysis:oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis[J]. Aliment Pharmacol Ther, 2012, 35(6):674-689.
11
Boglione L, D′Avolio A, Cariti G, et al. Telbivudine in the treatment of hepatitis B-associated cryoglobulinemia[J]. J Clin Virol, 2013, 56(2):167-169.
12
Mazzaro C, Dal Maso L, Urraro T, et al. Hepatitis B virus related cryoglobulinemic vasculitis:A multicentre open label study from the Gruppo Italiano di Studio delle Crioglobulinemie - GISC[J]. Dig Liver Dis, 2016, 48(7):780-784.
13
Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance[J]. Hepatology, 2018, 67(4):1560-1599.
14
Jimenez-Perez M, Gonzalez-Grande R, Mostazo Torres J, et al. Management of hepatitis B virus infection after liver transplantation[J]. World J Gastroenterol, 2015, 21(42):12083-12090.
15
Westin J, Aleman S, Castedal M, et al. Management of hepatitis B virus infection, updated Swedish guidelines[J]. Infect Dis (Lond), 2020, 52(1):1-22.
16
De Clercq E. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections[J]. Clin Microbiol Rev, 2003, 16(4):569-596.
17
Heathcote EJ, Marcellin P, Buti M, et al. Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B[J]. Gastroenterology, 2011140(1):132-143.
18
Giesler KE, Liotta DC. Next-generation reduction sensitive lipid conjugates of tenofovir: Antiviral activity and mechanism of release[J]. J Med Chem, 2016, 59(22):10244-10252.
19
任天棋,杨倩倩,马鹤铭,等. TAF治疗慢性乙型肝炎的研究进展[J]. 肝脏2019, 24(11):1319-1322.
20
Buti M, Gane E, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection:a randomised,double-blind, phase 3,non-inferiority trial[J]. Lancet Gastroenterol Hepatol, 2016, 1(3):196-206.
21
Murakami E, Wang T, Park Y, et al. Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy[J]. Antimicrob Agents Chemother, 2015, 59(6):3563-3569.
22
Cholongitas E, Tziomalos K, Pipili C. Management of patients with hepatitis B in special populations[J]. World J Gastroenterol, 2015, 21(6):1738-1748.
23
Tanaka T, Renner EL, Selzner N, et al. One year of hepatitis B immunoglobulin plus tenofovir therapy is safe and effective in preventing recurrent hepatitis B post-liver transplantation[J]. Can J Gastroenterol Hepatol, 2014, 28(1):41-44.
24
Cholongitas E, Papatheodoridis GV. High genetic barrier nucleos(t)ide analogue(s) for prophylaxis from hepatitis B virus recurrence after liver transplantation: A systematic review[J]. Am J Transplant, 2013, 13(2):353-362.
25
Cholongitas E, Goulis I, Antoniadis N, et al. New nucleos(t)ide analogue monoprophylaxis after cessation of hepatitis B immunoglobulin is effective against hepatitis B recurrence[J]. Transpl Int, 2014, 27(10):1022-1028.
26
Manini MA, Whitehouse G, Bruce M, et al. Entecavir or tenofovir monotherapy prevents HBV recurrence in liver transplant recipients: A 5-year follow-up study after hepatitis B immunoglobulin withdrawal[J]. Dig Liver Dis, 2018, 50(9):944-953.
27
Rashidi-Alavijeh J, Straub K, Achterfeld A, et al. Safety and efficacy of tenofovir alafenamide in liver transplant recipients:A single center experience[J]. Transpl Infect Dis, 2020:e13522.
28
Chan HL, Fung S, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection:a randomised,double-blind, phase 3, non-inferiority trial[J]. Lancet Gastroenterol Hepatol, 2016, 1(3):185-195.
29
Saab S, Song D, Challita YP, et al. Long-term outcomes with oral therapy in liver transplant recipients with hepatitis B[J]. Clin transplant, 2019:e13740.
30
Gara N, Zhao X, Collins MT, et al. Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B[J]. Aliment Pharmacol Ther, 2012, 35(11):1317-1325.
31
Wong GL, Tse YK, Wong VW, et al. Long-term safety of oral nucleos(t)ide analogs for patients with chronic hepatitis B: A cohort study of 53,500 subjects[J]. Hepatology, 2015, 62(3):684-693.
32
Lee D, Yun BC, Seo KI, et al. Risk factors associated with hypophosphatemia in chronic Hepatitis B patients treated with tenofovir disoproxil fumarate[J]. Medicine, 2019, 98(50):e18351.
33
Vasudevan A, Ardalan ZS, Ahmed N, et al. Long-term safety and efficacy of tenofovir disoproxil fumarate substitution for hepatitis B immunoglobulin following liver transplantation[J]. JGH Open, 2018, 2(6):288-294.
34
Wong GL, Seto WK, Wong VW, et al. Review article:long-term safety of oral anti-viral treatment for chronic hepatitis B[J]. Aliment Pharmacol Ther, 2018, 47(6):730-737.
35
Sripongpun P, Mannalithara A, Kwo PY, et al. Potential benefits of switching liver transplant recipients to tenofovir alafenamide prophylaxis[J]. Clin Gastroenterol Hepatol, 2020, 18(3): 747-749.
36
European Association for the Study of the Liver. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection[J]. J Hepatol, 2017, 67(2):370-398.
37
European Association for the Study of the Liver. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection[J]. J Hepatol, 2012, 57(1):167-185.
38
Rockstroh JK, Bhagani S, Benhamou Y, et al. European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of chronic hepatitis B and C coinfection in HIV-infected adults[J]. HIV Med, 2008, 9(2):82-88.
39
Yang JX, Liu BM, Li XG, et al. Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients[J]. Antivir Ther, 2010, 15(8):1171-1178.
40
Tan J, Degertekin B, Wong SN, et al. Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations[J]. J Hepatol, 2008, 48(3):391-398.
41
Jiang D, Wang J, Zhao X, et al. Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance[J]. Liver Int, 2020, 40(1):83-91.
42
Park ES, Lee AR, Kim DH, et al. Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients[J]. J Hepatol, 2019, 70(6):1093-1102.
43
Cathcart AL, Chan HL, Bhardwaj N, et al. No resistance to tenofovir alafenamide detected through 96 weeks of treatment in patients with chronic hepatitis B infection[J]. Antimicrob Agents Chemother, 2018, 62(10):e01064-18.
44
Yeh CT, Chien RN, Chu CM, et al. Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy[J]. Hepatology, 2000, 31(6):1318-1326.
45
Yatsuji H, Noguchi C, Hiraga N, et al. Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif[J]. Antimicrob Agents Chemother, 2006, 50(11):3867-5874.
46
Villet S, Pichoud C, Billioud G, et al. Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure[J]. J Antimicrob Chemother, 2008, 48(5):747-755.
[1] 陈进宏. 腹腔镜活体供肝获取规范与创新[J/OL]. 中华普通外科学文献(电子版), 2024, 18(05): 324-324.
[2] 胡宁宁, 赵延荣, 王栋, 王胜亮, 郭源. FMNL3与肝细胞癌肝移植受者预后的相关性研究[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 283-288.
[3] 仲福顺, 余露, 范晓礼, 叶啟发. 肝移植治疗肝上皮样血管内皮瘤一例[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 293-297.
[4] 刘冉佳, 崔向丽, 周效竹, 曲伟, 朱志军. 儿童肝移植受者健康相关生存质量评价的荟萃分析[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 302-309.
[5] 贺健, 张骊, 王洪海, 蒋文涛. 肝移植术后脾功能亢进转归及治疗研究进展[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 310-314.
[6] 王淑贤, 张良灏, 王利君, 张慧, 郭源, 许传屾, 李志强, 蔡金贞, 解曼, 饶伟. 成人肝移植围手术期严重心血管事件危险因素分析及预测模型研究[J/OL]. 中华移植杂志(电子版), 2024, 18(04): 222-229.
[7] 张丽娜, 邢建坤, 张梁, 李云生, 王兢, 孙丽莹, 朱志军. 婴幼儿活体肝移植受者术中麻醉护理单中心经验[J/OL]. 中华移植杂志(电子版), 2024, 18(04): 235-238.
[8] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[9] 刘敏思, 李荣, 李媚. 基于GGT与Plt比值的模型在HBV相关肝细胞癌诊断中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 831-835.
[10] 魏志鸿, 刘建勇, 吴小雅, 杨芳, 吕立志, 江艺, 蔡秋程. 肝移植术后急性移植物抗宿主病的诊治(附四例报告)[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 846-851.
[11] 傅斌生, 冯啸, 杨卿, 曾凯宁, 姚嘉, 唐晖, 刘剑戎, 魏绪霞, 易慧敏, 易述红, 陈规划, 杨扬. 脂肪变性供肝在成人劈离式肝移植中的应用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 789-794.
[12] 中华医学会器官移植学分会, 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组, 华南劈离式肝移植联盟. 劈离式供肝儿童肝移植中国临床操作指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 593-601.
[13] 刘军, 丘文静, 孙方昊, 李松盈, 易述红, 傅斌生, 杨扬, 罗慧. 在体与离体劈离式肝移植在儿童肝移植中的应用比较[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 688-693.
[14] 董佳, 王坤, 张莉. 预后营养指数结合免疫球蛋白、血糖及甲胎蛋白对HBV 相关慢加急性肝衰竭患者治疗后预后不良的预测价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 555-559.
[15] 黄圣楷, 许斌, 苏健, 孙龙. 海南省2010~2020年乙型肝炎流行趋势的时间序列分析及预测[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 555-561.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?