切换至 "中华医学电子期刊资源库"

中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 302 -306. doi: 10.3877/cma.j.issn.1674-3903.2021.05.010

综述

乙型肝炎肝移植术后新型核苷(酸)类似物的应用研究进展
翟慧敏1, 解曼1, 孔心涓1, 饶伟2,()   
  1. 1. 266000 青岛大学附属医院消化内科
    2. 266000 青岛大学附属医院器官移植中心 肝脏病中心 青岛大学移植医学研究所
  • 收稿日期:2021-04-02 出版日期:2021-10-25
  • 通信作者: 饶伟
  • 基金资助:
    青岛大学医学部"临床医学+X"科研课题(2017223)

Application progression of new nucleos(t)ide analogues in hepatitis B related liver transplantation

Huimin Zhai1, Man Xie1, Xinjuan Kong1, Wei Rao2,()   

  1. 1. Department of Gastroenterology, Qingdao University, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
    2. Center for Organ Transplantation, Liver Disease Center, Institute of Transplantation Science, Qingdao University, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2021-04-02 Published:2021-10-25
  • Corresponding author: Wei Rao
引用本文:

翟慧敏, 解曼, 孔心涓, 饶伟. 乙型肝炎肝移植术后新型核苷(酸)类似物的应用研究进展[J]. 中华移植杂志(电子版), 2021, 15(05): 302-306.

Huimin Zhai, Man Xie, Xinjuan Kong, Wei Rao. Application progression of new nucleos(t)ide analogues in hepatitis B related liver transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 302-306.

乙型肝炎复发是乙型肝炎肝移植受者术后面临的常见问题之一。近年来,核苷(酸)类似物(NAs)的应用极大地降低了肝移植术后乙型肝炎复发率,但其长期应用也带来了诸如HBV耐药及肾功能损伤等弊端。富马酸替诺福韦酯(TDF)和富马酸丙酚替诺福韦(TAF)均属于治疗乙型肝炎的低耐药NAs,其在肝移植领域的临床应用显示出良好的疗效和耐受性,尤其是在单一NAs预防肝移植术后乙型肝炎复发方面,具有较好的应用前景。本文对TDF和TAF等新型NAs在乙型肝炎肝移植术后的最新应用进展作一综述。

Hepatitis B virus (HBV) reactivation is one of the common problems faced by HBV-related recipients after liver transplantation. Recently, the application of nucleos(t)ide analogues (NAs) has greatly reduced the recurrence rate of HBV after liver transplantation, and long-term medication has also brought many disadvantages, such as drug resistance, kidney damage. Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide fumarate (TAF) are both high genetic barrier NAs, and clinical applications show that they have good efficacy and tolerability, especially NAs monoprophylaxis have a good application prospect against HBV reactivation after liver transplantation. This article reviews the latest application progress of TDF and TAF after liver transplantation.

1
WHO. Global hepatitis report, 2017[EB/OL]. (2019-11-06)[2021-03-31].

URL    
2
王贵强,王福生,庄辉,等. 慢性乙型肝炎防治指南(2019年版)[J]. 临床肝胆病杂志2019, 35(12):2648-2669.
3
Pfitzmann R, Nussler NC, Hippler-Benscheidt M, et al. Long-term results after liver transplantation[J]. Transpl Int, 2008, 21(3):234-246.
4
Todo S, Demetris AJ, Van Thiel D, et al. Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease[J]. Hepatology, 1991, 13(4):619-626.
5
O′Grady JG, Smith HM, Davies SE, et al. Hepatitis B virus reinfection after orthotopic liver transplantation. Serological and clinical implications[J]. J Hepatol, 1992, 14(1):104-111.
6
Lake JR, Wright TL. Liver transplantation for patients with hepatitis B: What have we learned from our results?[J]. Hepatology, 1991, 13(4):796-799.
7
Terrault NA, Bzowej NH, Chang KM, et al. AASLD guidelines for treatment of chronic hepatitis B[J]. Hepatology, 2016, 63(1):261-283.
8
Lok AS, McMahon BJ, Brown RS, et al. Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis[J]. Hepatology, 2016, 63(1):284-306.
9
Peng CY, Chien RN, Liaw YF. Hepatitis B virus-related decompensated liver cirrhosis: benefits of antiviral therapy[J]. J Hepatol, 2012, 57(2):442-450.
10
Singal AK, Fontana RJ. Meta-analysis:oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis[J]. Aliment Pharmacol Ther, 2012, 35(6):674-689.
11
Boglione L, D′Avolio A, Cariti G, et al. Telbivudine in the treatment of hepatitis B-associated cryoglobulinemia[J]. J Clin Virol, 2013, 56(2):167-169.
12
Mazzaro C, Dal Maso L, Urraro T, et al. Hepatitis B virus related cryoglobulinemic vasculitis:A multicentre open label study from the Gruppo Italiano di Studio delle Crioglobulinemie - GISC[J]. Dig Liver Dis, 2016, 48(7):780-784.
13
Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance[J]. Hepatology, 2018, 67(4):1560-1599.
14
Jimenez-Perez M, Gonzalez-Grande R, Mostazo Torres J, et al. Management of hepatitis B virus infection after liver transplantation[J]. World J Gastroenterol, 2015, 21(42):12083-12090.
15
Westin J, Aleman S, Castedal M, et al. Management of hepatitis B virus infection, updated Swedish guidelines[J]. Infect Dis (Lond), 2020, 52(1):1-22.
16
De Clercq E. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections[J]. Clin Microbiol Rev, 2003, 16(4):569-596.
17
Heathcote EJ, Marcellin P, Buti M, et al. Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B[J]. Gastroenterology, 2011140(1):132-143.
18
Giesler KE, Liotta DC. Next-generation reduction sensitive lipid conjugates of tenofovir: Antiviral activity and mechanism of release[J]. J Med Chem, 2016, 59(22):10244-10252.
19
任天棋,杨倩倩,马鹤铭,等. TAF治疗慢性乙型肝炎的研究进展[J]. 肝脏2019, 24(11):1319-1322.
20
Buti M, Gane E, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection:a randomised,double-blind, phase 3,non-inferiority trial[J]. Lancet Gastroenterol Hepatol, 2016, 1(3):196-206.
21
Murakami E, Wang T, Park Y, et al. Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy[J]. Antimicrob Agents Chemother, 2015, 59(6):3563-3569.
22
Cholongitas E, Tziomalos K, Pipili C. Management of patients with hepatitis B in special populations[J]. World J Gastroenterol, 2015, 21(6):1738-1748.
23
Tanaka T, Renner EL, Selzner N, et al. One year of hepatitis B immunoglobulin plus tenofovir therapy is safe and effective in preventing recurrent hepatitis B post-liver transplantation[J]. Can J Gastroenterol Hepatol, 2014, 28(1):41-44.
24
Cholongitas E, Papatheodoridis GV. High genetic barrier nucleos(t)ide analogue(s) for prophylaxis from hepatitis B virus recurrence after liver transplantation: A systematic review[J]. Am J Transplant, 2013, 13(2):353-362.
25
Cholongitas E, Goulis I, Antoniadis N, et al. New nucleos(t)ide analogue monoprophylaxis after cessation of hepatitis B immunoglobulin is effective against hepatitis B recurrence[J]. Transpl Int, 2014, 27(10):1022-1028.
26
Manini MA, Whitehouse G, Bruce M, et al. Entecavir or tenofovir monotherapy prevents HBV recurrence in liver transplant recipients: A 5-year follow-up study after hepatitis B immunoglobulin withdrawal[J]. Dig Liver Dis, 2018, 50(9):944-953.
27
Rashidi-Alavijeh J, Straub K, Achterfeld A, et al. Safety and efficacy of tenofovir alafenamide in liver transplant recipients:A single center experience[J]. Transpl Infect Dis, 2020:e13522.
28
Chan HL, Fung S, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection:a randomised,double-blind, phase 3, non-inferiority trial[J]. Lancet Gastroenterol Hepatol, 2016, 1(3):185-195.
29
Saab S, Song D, Challita YP, et al. Long-term outcomes with oral therapy in liver transplant recipients with hepatitis B[J]. Clin transplant, 2019:e13740.
30
Gara N, Zhao X, Collins MT, et al. Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B[J]. Aliment Pharmacol Ther, 2012, 35(11):1317-1325.
31
Wong GL, Tse YK, Wong VW, et al. Long-term safety of oral nucleos(t)ide analogs for patients with chronic hepatitis B: A cohort study of 53,500 subjects[J]. Hepatology, 2015, 62(3):684-693.
32
Lee D, Yun BC, Seo KI, et al. Risk factors associated with hypophosphatemia in chronic Hepatitis B patients treated with tenofovir disoproxil fumarate[J]. Medicine, 2019, 98(50):e18351.
33
Vasudevan A, Ardalan ZS, Ahmed N, et al. Long-term safety and efficacy of tenofovir disoproxil fumarate substitution for hepatitis B immunoglobulin following liver transplantation[J]. JGH Open, 2018, 2(6):288-294.
34
Wong GL, Seto WK, Wong VW, et al. Review article:long-term safety of oral anti-viral treatment for chronic hepatitis B[J]. Aliment Pharmacol Ther, 2018, 47(6):730-737.
35
Sripongpun P, Mannalithara A, Kwo PY, et al. Potential benefits of switching liver transplant recipients to tenofovir alafenamide prophylaxis[J]. Clin Gastroenterol Hepatol, 2020, 18(3): 747-749.
36
European Association for the Study of the Liver. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection[J]. J Hepatol, 2017, 67(2):370-398.
37
European Association for the Study of the Liver. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection[J]. J Hepatol, 2012, 57(1):167-185.
38
Rockstroh JK, Bhagani S, Benhamou Y, et al. European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of chronic hepatitis B and C coinfection in HIV-infected adults[J]. HIV Med, 2008, 9(2):82-88.
39
Yang JX, Liu BM, Li XG, et al. Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients[J]. Antivir Ther, 2010, 15(8):1171-1178.
40
Tan J, Degertekin B, Wong SN, et al. Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations[J]. J Hepatol, 2008, 48(3):391-398.
41
Jiang D, Wang J, Zhao X, et al. Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance[J]. Liver Int, 2020, 40(1):83-91.
42
Park ES, Lee AR, Kim DH, et al. Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients[J]. J Hepatol, 2019, 70(6):1093-1102.
43
Cathcart AL, Chan HL, Bhardwaj N, et al. No resistance to tenofovir alafenamide detected through 96 weeks of treatment in patients with chronic hepatitis B infection[J]. Antimicrob Agents Chemother, 2018, 62(10):e01064-18.
44
Yeh CT, Chien RN, Chu CM, et al. Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy[J]. Hepatology, 2000, 31(6):1318-1326.
45
Yatsuji H, Noguchi C, Hiraga N, et al. Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif[J]. Antimicrob Agents Chemother, 2006, 50(11):3867-5874.
46
Villet S, Pichoud C, Billioud G, et al. Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure[J]. J Antimicrob Chemother, 2008, 48(5):747-755.
[1] 高建松, 陈晓晓, 冯婷, 包剑锋, 魏淑芳, 潘林. 基于超声瞬时弹性成像的多参数决策树模型评估慢性乙型肝炎患者肝纤维化等级[J]. 中华医学超声杂志(电子版), 2023, 20(09): 923-929.
[2] 葛飞霞, 蒋银, 杨丹. 酶联免疫吸附测定法与PCR仪检测在乙型肝炎诊断中的临床应用[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 310-315.
[3] 张小曼, 马筱秋, 许正锯, 张纯瑜, 何彩婷. 乙型肝炎病毒逆转录酶区耐药突变对血清乙型肝炎病毒表面抗原水平的影响[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(05): 324-332.
[4] 李坤河, 寇萌佳, 邝立挺. 肝移植术后二次气管插管的危险因素及预测模型的建立[J]. 中华普通外科学文献(电子版), 2023, 17(05): 366-371.
[5] 吴方园, 孙霞, 林昌锋, 张震生. HBV相关肝硬化合并急性上消化道出血的危险因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 45-47.
[6] 中华医学会器官移植学分会, 中国医师协会器官移植医师分会, 上海医药行业协会. 中国肝、肾移植受者霉酚酸类药物应用专家共识(2023版)[J]. 中华移植杂志(电子版), 2023, 17(05): 257-272.
[7] 陆闻青, 陈昕怡, 任雪飞. 遗传代谢病儿童肝移植受者术后生活质量调查研究[J]. 中华移植杂志(电子版), 2023, 17(05): 287-292.
[8] 范铁艳, 李君, 陈虹. 肝移植术后新发戊型病毒性肝炎的诊治经验[J]. 中华移植杂志(电子版), 2023, 17(05): 293-296.
[9] 陈朔, 陈峰, 程飞, 项捷. 糖原累积病Ⅰ型并发胰腺炎肝移植术后胰腺梗死一例[J]. 中华移植杂志(电子版), 2023, 17(05): 300-302.
[10] 汤鹏昊, 张武. 肠道微生态与肝移植围手术期并发症相关研究进展[J]. 中华移植杂志(电子版), 2023, 17(05): 303-307.
[11] 严庆, 刘颖, 邓斐文, 陈焕伟. 微血管侵犯对肝癌肝移植患者生存预后的影响[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 624-629.
[12] 廖梅, 张红君, 金洁玚, 吕艳, 任杰. 床旁超声造影对肝移植术后早期肝动脉血栓的诊断价值[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 630-634.
[13] 李秉林, 吕少诚, 潘飞, 姜涛, 樊华, 寇建涛, 贺强, 郎韧. 供肝灌注液病原菌与肝移植术后早期感染的相关性分析[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 656-660.
[14] 吕垒, 冯啸, 何凯明, 曾凯宁, 杨卿, 吕海金, 易慧敏, 易述红, 杨扬, 傅斌生. 改良金氏评分在儿童肝豆状核变性急性肝衰竭肝移植手术时机评估中价值并文献复习[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 661-668.
[15] 王孟龙. 肿瘤生物学特征在肝癌肝移植治疗中的意义[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 490-494.
阅读次数
全文


摘要