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中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (06) : 321 -328. doi: 10.3877/cma.j.issn.1674-3903.2022.06.001

所属专题: 指南共识

专家共识

中国心脏死亡捐献器官评估与应用专家共识(2022版)
中国医师协会器官移植医师分会, 中华医学会器官移植学分会, 中华医学会外科学分会移植学组, 中国医院协会器官获取与分配工作委员会   
  1. 1. 浙江大学医学院,杭州 310058
  • 收稿日期:2022-11-15 出版日期:2022-12-25
  • 基金资助:
    十四五国家重点研发计划(2021YFA1100502,2021YFA1100504); 国家自然科学基金重大研究计划(92159202); 国家自然科学基金重点项目(81930016); 浙江省科技厅"尖兵""领雁"研发攻关计划(2022C03108)

Expert consensus on evaluation and application of organs donated after cardiac death in China (2022 edition)

Chinese College of Transplant Doctors, Chinese Society of Organ Transplantation, Section of Organ Transplantation, Chinese Society of Surgery, Chinese Hospital Association Organ Procurement and Dispensation Work Committee   

  • Received:2022-11-15 Published:2022-12-25
引用本文:

中国医师协会器官移植医师分会, 中华医学会器官移植学分会, 中华医学会外科学分会移植学组, 中国医院协会器官获取与分配工作委员会. 中国心脏死亡捐献器官评估与应用专家共识(2022版)[J]. 中华移植杂志(电子版), 2022, 16(06): 321-328.

Chinese College of Transplant Doctors, Chinese Society of Organ Transplantation, Section of Organ Transplantation, Chinese Society of Surgery, Chinese Hospital Association Organ Procurement and Dispensation Work Committee. Expert consensus on evaluation and application of organs donated after cardiac death in China (2022 edition)[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(06): 321-328.

我国器官捐献与移植事业已进入发展新阶段,心脏死亡捐献(DCD)在器官捐献中的占比逐年下降。为了更科学、规范地指导DCD器官的评估与应用,保障移植疗效。中国医师协会器官移植医师分会、中华医学会器官移植学分会、中华医学会外科学分会移植学组和中国医院协会器官获取与分配工作委员会组织专家,在《中国心脏死亡捐献器官评估与应用专家共识(2014版)》基础上,综合近年循证医学证据及临床经验,予以更新。

The organ donation and transplantation in China has entered a new stage. The proportion of donation after cardiac death (DCD) in organ donation has decreased year by year. In order to guide the evaluation and application of DCD organs more scientifically and normatively, and ensure the transplantation effect, the Chinese College of Transplant Doctors, the Chinese Society of Organ Transplantation, the Section of Organ Transplantation, Chinese Society of Surgery, and the Chinese Hospital Association Organ Procurement and Dispensation Work Committee organize experts to update the latest progress on the basis of the Expert consensus on evaluation and application of organ donation after cardiac death in China (2014 edition), combing with evidence-based medical proof and clinical experience in recent years.

1
中华医学会器官移植学分会. 中国心脏死亡器官捐献工作指南(第2版)[J/CD]. 中华移植杂志:电子版20126(3):221-224.
2
石炳毅,郑树森,刘永锋. 中国器官移植临床诊疗指南[M]. 北京:人民卫生出版社,2017.
3
中华医学会器官移植学分会. 中国公民逝世后器官捐献流程和规范(2019版)[J]. 器官移植201910(2):122-127.
4
中华医学会器官移植学分会,中国医师协会器官移植医师分会. 体外膜肺氧合在中国公民逝世后捐献供器官保护中的应用专家共识(2016版)[J/CD]. 中华移植杂志:电子版201610(3):107-111.
5
Kalisvaart M, Croome KP, Hernandez-Alejandro R, et al. Donor warm ischemia time in DCD liver transplantation working group report from the ILTS DCD, liver preservation, and machine perfusion consensus conference[J]. Transplantation, 2021105(6):1156-1164.
6
Coffey JC, Wanis KN, Monbaliu D, et al. The influence of functional warm ischemia time on DCD liver transplant recipients′ outcomes[J]. Clin Transplant, 201731(10):e13068.
7
中国医师协会器官移植医师分会,中华医学会外科学分会移植学组,中国肝移植注册中心科学委员会,等. 中国移植器官保护专家共识(2016版)[J]. 中华外科杂志201654(8):568-576.
8
中华医学会器官移植学分会. 中国肝移植供肝获取技术规范(2019版)[J/CD]. 中华移植杂志:电子版201913(3):167-170.
9
中国肝移植注册中心,国家肝脏移植质控中心,国家人体捐献器官获取质控中心,等. 中国移植器官保护专家共识(2022版)[J]. 中华普通外科杂志202237(5):387-394.
10
施辉波,王心强,徐晶,等.《移植器官质量与安全指南(第6版)》解读——器官的获取、保存和运输[J]. 器官移植202011(2):276-281.
11
徐骁,卫强,周军彬. 常温机械灌注开启肝移植新时代[J]. 中华器官移植杂志202041(10):579-582.
12
汪恺,苏仁义,王周城,等. "机械灌注+"视阈下扩大标准供肝的修复与功能提升[J]. 中华消化外科杂志202221(1):74-78.
13
Wang W, Xie D, Hu X, et al. Effect of hypothermic machine perfusion on the preservation of kidneys donated after cardiac death: a single-center, randomized, controlled trial[J]. Artif Organs, 201741(8):753-758.
14
Dutkowski P, Polak WG, Muiesan P, et al. First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an international-matched case analysis[J]. Ann Surg, 2015262(5):764-771.
15
Nemes B, Gámán G, Polak WG, et al. Extended-criteria donors in liver transplantation part Ⅱ:reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation[J]. Expert Rev Gastroenterol Hepatol, 201610(7):841-859.
16
Schlegel A, Muller X, Kalisvaart M, et al. Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation[J]. J Hepatol, 201970(1):50-57.
17
Nasralla D, Coussios CC, Mergental H, et al. A randomized trial of normothermic preservation in liver transplantation[J]. Nature, 2018557(7703):50-56.
18
Morito N, Obara H, Matsuno N, et al. Oxygen consumption during hypothermic and subnormothermic machine perfusions of porcine liver grafts after cardiac death[J]. J Artif Organs, 2018, 21(4): 450-457.
19
Ciria R, Ayllon-Teran MD, González-Rubio S, et al. Rescue of discarded grafts for liver transplantation by ex vivo subnormothermic and normothermic oxygenated machine perfusion: first experience in Spain[J]. Transplant Proc, 201951(1):20-24.
20
Zhou J, Wei Q, Zheng S, et al. Early allograft dysfunction after liver transplantation with donation after cardiac death donors[J]. Hepatobiliary Surg Nutr, 20198(5):566-568.
21
Justo I, Nutu A, García-Conde M, et al. Incidence and risk factors of primary non-function after liver transplantation using grafts from uncontrolled donors after circulatory death[J]. Clin Transplant, 202135(1):e14134.
22
Ly M, Crawford M, Verran D. Biliary complications in donation after circulatory death liver transplantation: the Australian National Liver Transplantation Unit′s experience[J]. ANZ J Surg, 202191(3):445-450.
23
Laing RW, Scalera I, Isaac J, et al. Liver transplantation using grafts from donors after circulatory death: a propensity score-matched study from a single center[J]. Am J Transplant, 201616(6):1795-1804.
24
中国医师协会器官移植医师分会,中华医学会器官移植学分会. 中国实体器官移植手术部位感染管理专家共识(2022版)[J]. 中华临床感染病杂志202215(3):164-175.
25
He YB, Sun JS, Wang ZP, et al. Risk factors of early liver dysfunction after liver transplantation using grafts from donation after citizen death donors[J]. Transpl Immunol, 202271:101525.
26
Schlegel A, Kalisvaart M, Scalera I, et al. The UK DCD risk score: a new proposal to define futility in donation-after circulatory-death liver transplantation[J]. J Hepatol, 201868(3):456-464.
27
杨梦凡,魏绪勇,王琨,等. 高龄供肝对肝移植术后并发症的影响——148例受者预后分析及思考[J/CD]. 实用器官移植电子杂志20208(2):101-105.
28
Farid SG, Attia MS, Vijayanand D, et al. Impact of donor hepatectomy time during organ procurement in donation after circulatory death liver transplantation: the United Kingdom experience[J]. Transplantation, 2019103(4):e79-e88.
29
Wu D, Chen C, Liu T, et al. Epidemiology, susceptibility, and risk factors associated with mortality in carbapenem resistant gram-negative bacterial infections among abdominal solid organ transplant recipients: a retrospective cohort study[J]. Infect Dis Ther, 202110(1):559-573.
30
Croome KP, Mathur AK, Mao S, et al. Perioperative and long-term outcomes of utilizing donation after circulatory death liver grafts with macrosteatosis: a multicenter analysis[J]. Am J Transplant, 2020, 20(9): 2449-2456.
31
Kesseli SJ, Gloria JN, Abraham N, et al. Point-of-care assessment of DCD livers during normothermic machine perfusion in a nonhuman primate model[J]. Hepatol Commun, 20215(9):1527-1542.
32
de Kok M, Schaapherder A, Alwayn I, et al. Improving outcomes for donation after circulatory death kidney transplantation: Science of the times[J]. PLoS One, 202015(7):e0236662.
33
Pushpakumar S, Kundu S, Weber G, et al. Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage mediated inflammation in ischemia reperfusion injury of the aged kidney[J]. Geroscience, 202143(3):1349-1367.
34
Heilman RL, Mathur A, Smith ML, et al. Increasing the use of kidneys from unconventional and high-risk deceased donors[J]. Am J Transplant, 201616(11):3086-3092.
35
Jadlowiec CC, Heilman RL, Smith ML, et al. Transplanting kidneys from donation after cardiac death donors with acute kidney injury[J]. Am J Transplant, 202020(3):864-869.
36
中华医学会器官移植学分会. 器官移植病理学临床技术操作规范(2019版)——总论与肾移植[J]. 器官移植201910(2):128-141.
37
中华医学会器官移植学分会,中国医师协会器官移植医师分会. 中国公民逝世后器官捐献供肾体外低温机械灌注保存专家共识(2016版)[J/CD]. 中华移植杂志:电子版201610(4):154-158.
38
Verstraeten L, Jochmans I. Sense and sensibilities of organ perfusion as a kidney and liver viability assessment platform[J]. Transpl Int, 202235:10312.
39
Mihaylov P, Mangus R, Ekser B, et al. Expanding the donor pool with the use of extended criteria donation after circulatory death livers[J]. Liver Transpl, 201925(8):1198-1208.
40
Bastos-Neves D, Salvalaggio P, Almeida MD. Risk factors, surgical complications and graft survival in liver transplant recipients with early allograft dysfunction[J]. Hepatobiliary Pancreat Dis Int, 201918(5):423-429.
41
中华医学会外科学分会外科手术学学组,中华医学会外科学分会移植学组. 劈离式肝移植供体及供肝评估专家共识[J/CD]. 中华肝脏外科手术学电子杂志202211(2):133-138.
42
田大治,蒋文涛,陈池义,等. 中重度脂肪变性供肝应用于成人肝移植术的早期预后及其危险因素分析[J]. 器官移植202011(6):698-703,736.
43
杨梦凡,王睿,潘斌华,等. 脂肪变性供肝用于肝癌肝移植的预后及影响因素多中心研究[J]. 中华消化外科杂志202221(2):237-248.
44
袁梦淑,宋红丽. 脂肪变性供肝在肝移植中的应用现状与进展[J/CD]. 实用器官移植电子杂志202210(2):162-165.
45
Yu J, Shi X, Yu H, et al. Impact of hepatitis B surface antigen positive grafts on liver transplantation in patients with benign and malignant liver disease[J]. J Med Virol, 202294(7):3338-3348.
46
Thuluvath PJ, Bruno DA, Alukal J, et al. Use of HCV-positive livers in HCV-negative recipients[J]. Am J Gastroenterol, 2020115(7):1045-1054.
47
Danford CJ, Redman JS, Alonso D. Hepatitis C-positive liver transplantation: outcomes and current practice[J]. Curr Opin Organ Transplant, 202126(2):115-120.
48
郑秉暄,豆猛,石玉婷,等. 老年器官捐献供肾在不同年龄肾移植受者中发生急性排斥反应的临床观察[J]. 中华器官移植杂志202142(6):336-339.
49
陈根,张毅,彭贵主,等. 器官捐献肾移植功能延迟恢复的预后因素分析[J]. 中国微创外科杂志201717(6):487-490.
50
陈旭春,程颖. 机械灌注在肾移植中的应用进展[J/CD]. 实用器官移植电子杂志202210(3):196-200,192.
51
晏强,韦晓莲,李飞,等. 机械灌注应用在肾移植中的效果评价(附36例报道)[J]. 器官移植20145(3):182-185.
52
Sánchez-Escuredo A, Sagasta A, Revuelta I, et al. Histopathological evaluation of pretransplant donor biopsies in expanded criteria donors with high kidney donor profile index: a retrospective observational cohort study[J]. Transpl Int, 201730(10):975-986.
53
胡歆,陈荣高,孟锦雯,等. 高龄肝移植受者预后和影响因素分析的多中心研究[J].中华消化外科杂志202120(10):1047-1054.
54
Wang K, Lu D, Liu Y, et al. Severity of early allograft dysfunction following donation after circulatory death liver transplantation: a multicentre study[J]. Hepatobiliary Surg Nutr, 202110(1):9-19.
55
Bleszynski MS, Punnen S, Desai S, et al. Outcomes of liver transplant recipients with high MELD scores: an experience from a Canadian centre[J]. Can J Surg, 202265(4): E425-E439.
56
李杨,董博清,胡筱筠,等. 合并糖尿病的终末期肾病患者肾移植术后的近期效果分析[J]. 中华器官移植杂志202041(8):459-463.
57
张水军. 加速康复外科在器官移植中的研究与展望[J/CD]. 实用器官移植电子杂志20197(6):423-425,408.
58
陈思敏,张颖,曹宏泰,等. 加速康复外科在公民逝世后器官捐献肝移植围手术期的实践[J/CD]. 中华普通外科学文献:电子版202216(4):290-292.
59
张景晓,刘懿禾. 肝移植围术期人工肝支持治疗[J/CD]. 实用器官移植电子杂志20208(4):308-312.
60
陈佳佳,范林骁,李兰娟. 《肝衰竭诊治指南(2018版)》指南解读[J]. 中国临床医生杂志202048(11):1279-1282.
61
Li P, Liang X, Xu S, et al. A non-bioartificial liver support system combined with transplantation in HBV-related acuteon-chronic liver failure[J]. Sci Rep, 202111(1):2975.
62
Nemes B, Gámán G, Polak WG, et al. Extended criteria donors in liver transplantation PartⅠ:reviewing the impact of determining factors[J]. Expert Rev Gastroenterol Hepatol, 201610(7):827-839.
63
王万里,李青山,周颖,等. DCD供肝肝移植术后早期急性肾损伤相关危险因素分析[J]. 器官移植20189(2):130-136.
64
Umbro I, Tinti F, Scalera I, et al. Acute kidney injury and post-reperfusion syndrome in liver transplantation[J]. World J Gastroenterol, 2016, 22(42): 9314-9323.
65
杨扬,邓宜南. 抗体免疫诱导治疗在肝移植中的应用[J]. 临床肝胆病杂志201531(12):2031-2034.
66
Halldorson JB, Bakthavatsalam R, Montenovo M, et al. Differential rates of ischemic cholangiopathy and graft survival associated with induction therapy in DCD liver transplantation[J]. Am J Transplant, 201515(1):251-258.
67
Jones-Hughes T, Snowsill T, Haasova M, et al. Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model[J]. Health Technol Assess, 201620(62):1-594.
68
中华医学会器官移植学分会,中国医师协会器官移植医师分会. 中国肾移植受者免疫抑制治疗指南(2016版)[J]. 器官移植20167(5):327-331.
69
陈书进,缪朦秋,王家伟,等. 儿童心脏死亡器官捐献的现状与研究进展[J/CD]. 中华移植杂志:电子版201812(2):86-90.
70
van Rijn R, Hoogland P, Lehner F, et al. Long-term results after transplantation of pediatric liver grafts from donation after circulatory death donors[J]. PLoS One, 201712(4):e0175097.
71
Kizilbash SJ, Evans MD, Chavers BM. Survival benefit of donation after circulatory death kidney transplantation in children compared with remaining on the waiting list for a kidney donated after brain death[J]. Transplantation, 2022106(3):575-583.
72
中华医学会器官移植学分会. 儿童供肾的功能维护、评估及应用操作规范(2019版)[J]. 器官移植201910(5):494-498.
73
朱有华,江文诗. 合理利用儿童捐献器官发展我国儿童器官移植[J]. 中华器官移植杂志201839(2):67-70.
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