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中华移植杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 280 -284. doi: 10.3877/cma.j.issn.1674-3903.2025.04.012

综述

甲状腺激素在肝移植围手术期的作用及管理策略
周雪羽1, 吴俣2, 彭传会2,()   
  1. 1310003 杭州,浙江大学医学院附属第一医院甲状腺外科
    2310003 杭州,浙江大学医学院附属第一医院肝胆胰外科
  • 收稿日期:2025-02-10 出版日期:2025-08-25
  • 通信作者: 彭传会

The function and management policies of thyroid hormone in perioperative period of liver transplantation

Xueyu Zhou1, Yu Wu2, Chuanhui Peng2,()   

  1. 1Department of Thyroid Surgery, the First Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou 310003, China
    2Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou 310003, China
  • Received:2025-02-10 Published:2025-08-25
  • Corresponding author: Chuanhui Peng
引用本文:

周雪羽, 吴俣, 彭传会. 甲状腺激素在肝移植围手术期的作用及管理策略[J/OL]. 中华移植杂志(电子版), 2025, 19(04): 280-284.

Xueyu Zhou, Yu Wu, Chuanhui Peng. The function and management policies of thyroid hormone in perioperative period of liver transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2025, 19(04): 280-284.

肝移植是终末期肝病的重要治疗手段。甲状腺激素系统在肝移植围手术期中扮演着关键角色,其动态变化与患者术前状态、围手术期并发症的发生密切相关。甲状腺激素可通过核受体介导的信号网络调节肝脏代谢稳态与再生能力,而肝脏则通过调控甲状腺激素代谢、结合蛋白合成及胆汁排泄影响甲状腺功能状态。本文综述甲状腺激素在肝移植围手术期的作用和机制,以期为甲状腺激素围手术期的优化管理提供理论依据。

Liver transplantation is an important treatment method for the end-stage liver diseases. The thyroid hormone system plays a key role in the perioperative period of liver transplantation. Its dynamic changes are closely associated with the preoperative status of patients and the occurrence of perioperative complications. Thyroid hormone can regulate liver metabolic homeostasis and regenerative capacity through nuclear receptor-mediated signaling networks, while the liver affects thyroid functional status by regulating thyroid hormone metabolism, binding protein synthesis and bile excretion. Clarifying the role and mechanism of thyroid hormone in the perioperative period of liver transplantation can provide a theoretical basis for its optimal management during the perioperative period.

图1 肝移植围手术期甲状腺激素监测和管理流程图
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