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中华移植杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 274 -279. doi: 10.3877/cma.j.issn.1674-3903.2025.04.011

综述

Castleman病相关肾衰竭与肾移植预后
那淑芳1, 李玲1, 罗明1, 叶啟发1,2,()   
  1. 1430071 武汉,武汉大学中南医院 武汉大学肝胆疾病研究院 武汉大学移植医学中心 国家人体捐献器官获取质量控制中心 移植医学技术湖北省重点实验室
    2410013 长沙,中南大学湘雅三医院 国家卫生健康委移植医学转化研究重点实验室
  • 收稿日期:2024-11-13 出版日期:2025-08-25
  • 通信作者: 叶啟发
  • 基金资助:
    武汉大学中南医院优博基金(ZNYB20240002); 武汉大学中南医院医学人才攀登计划(PDJH202215)

Prognosis of Castleman′s disease-related renal failure and kidney transplantation

Shufang Na1, Ling Li1, Ming Luo1, Qifa Ye1,2,()   

  1. 1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
    2The 3rd Xiangya Hospital of Central South University, Engineering and Technology Research Center for Transplantation Medicine of National Health Commission, Changsha 410013, China
  • Received:2024-11-13 Published:2025-08-25
  • Corresponding author: Qifa Ye
引用本文:

那淑芳, 李玲, 罗明, 叶啟发. Castleman病相关肾衰竭与肾移植预后[J/OL]. 中华移植杂志(电子版), 2025, 19(04): 274-279.

Shufang Na, Ling Li, Ming Luo, Qifa Ye. Prognosis of Castleman′s disease-related renal failure and kidney transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2025, 19(04): 274-279.

Castleman病(CD)作为较为罕见的免疫反应性淋巴结病,以淋巴组织增生为特征。其中累及多个淋巴结或区域的多中心型Castleman病(MCD)会导致肾小球肾炎、淀粉样变性和间质性肾炎等,损伤肾功能。MCD导致的肾衰竭后进行肾移植虽比较罕见,但由于其治疗和预后复杂,更需要被重视。本文针对目前已有报道的CD与肾移植相关病例进行综述,旨在探讨MCD相关肾衰竭和肾移植的挑战与获益,为临床预防、诊治提供参考和借鉴。

Castleman′s disease (CD) is a rare reactive lymphoproliferative disorder characterized by lymphoid tissue hyperplasia. Multicentric Castleman′s disease (MCD), involving multiple lymph nodes or regions, can lead to conditions such as glomerulonephritis, amyloid nephropathy, and interstitial nephritis, resulting in impaired renal function. Therefore, close monitoring of renal function in patients with MCD is necessary during clinical practice. Although renal transplantation following renal failure caused by MCD is relatively rare, the complexity of treatment and prognosis warrants increased attention. This article reviews currently reported cases related to CD and kidney transplantation, aiming to explore the challenges and benefits of kidney transplantation in MCD patients with renal failure and to provide feasible recommendations for clinical practice.

表1 肾移植术后确诊Castleman病的病例报道
表2 确诊MCD后行肾移植的病例报道
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