Risk factors analysis for anemia within the first year post renal transplantation

doi:10.3877/cma.j.issn.1674-3903.2017.01.004

Abstract

Abstract:

Objective

To investigate the risk factors for anemia within the first year post renal transplantation.

Methods

The clinical data of 75 recipients getting renal transplantion in Zhongnan Hospital of Wuhan University during December 2013 and May 2015 was analyzed retrospectively. Blood parameters and tacrolimus plasma concentration of preoperative and postoperative 1, 3, 6, 12 months were observed. The patients were divided into PTA group (n=16) and non-PTA group (n=59) at 1 year after operation. The differences of sex, ACEI/ARB, infusion of erythrocytes, acute rejection and antiviral drugs between PTA group and non- PTA group were compared by χ² test. The age and serum creatinine levels were compared by t test. The correlation between hemoglobin and serum creatinine and tacrolimus was evaluated by Spearman rank correlation. P<0.05 was deemed statistically significant.

Results

The levels of serum creatinine in the recipients were normal at 1 month after operation. Hemoglobin was restored to more than 100g/L within 3 months after operation. The red blood cell count and tacrolimus plasma concentration were basically stable from 3 months to 1 year after operation. There was a negative correlation between hemoglobin and serum creatinine at 1, 3, and 12 months postoperatively (r=-0.369, -0.245, -0.226, P all<0.05). There was no correlation between hemoglobin and serum creatinine at 6 months after operation (r=-0.225, P>0.05). There was no correlation between hemoglobin and tacrolimus plasma concentration at 1, 3, 6, and 12 months after operation (r=-0.051, 0.124, 0.059, -0.002, P all>0.05). The incidence of PTA was 21% (16/75) 1 year after operation. The difference of serum creatinine between the PTA group and the non-PTA group was significant (t=18.27, P<0.05).

Conclusions

The incidence of anemia after renal transplantation is high. Reducing serum creatinine level of renal transplant recipients may have an improved effect on reduction of PTA.

Key words: Renal transplantation, Anemia, Risk factor, Serum creatinine

Mingxia Li, Qifa Ye, Guizhu Peng. Risk factors analysis for anemia within the first year post renal transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2017, 11(01): 15-18.

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Figures/Tables 2

References 23

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时间	血红蛋白(g/L)	MCV(fL)	MCH(pg)	红细胞计数(1×10¹²/L)	血清肌酐(μmol/L)	他克莫司血药浓度(ng/mL)
术前	104±19	92± 8	30±3	3.5±0.6	964±305	－
术后1个月	102±18^a	93± 8	30±3	3.4±0.6	122± 55^a	9.6±2.9
术后3个月	122±21^ab	90± 8	29±3	4.2±0.8^ab	107± 34^a	8.4±2.2^b
术后6个月	129±22^ab	88± 8	29±3	4.6±1.0^abc	112± 59^a	7.7±2.6^b
术后12个月	134±27^ab	87±10	29±3	4.7±1.0^abc	107± 43^a	7.6±2.4^bc

时间	血红蛋白(g/L)	MCV(fL)	MCH(pg)	红细胞计数(1×10¹²/L)	血清肌酐(μmol/L)	他克莫司血药浓度(ng/mL)
术前	104±19	92± 8	30±3	3.5±0.6	964±305	－
术后1个月	102±18^a	93± 8	30±3	3.4±0.6	122± 55^a	9.6±2.9
术后3个月	122±21^ab	90± 8	29±3	4.2±0.8^ab	107± 34^a	8.4±2.2^b
术后6个月	129±22^ab	88± 8	29±3	4.6±1.0^abc	112± 59^a	7.7±2.6^b
术后12个月	134±27^ab	87±10	29±3	4.7±1.0^abc	107± 43^a	7.6±2.4^bc

组别	例数	性别(例，男/女)	年龄(岁，±s)	ARB/ACEI(例，是/否)	抗病毒药物(例，是/否)	术后输注红细胞(例，是/否)	AR(例，是/否)	血清肌酐(μmol/L，±s)
PTA组	16	11/ 5	49± 9	5/11	7/ 9	5/11	4/12	134±65
非PTA组	59	46/13	40±11	18/41	12/47	12/47	10/49	99±31
χ²/t值	－	χ²＝0.19	t＝0.83	χ²＝0.00	χ²＝2.51	χ²＝0.35	χ²＝0.14	t＝18.27
P值	－	>0.05	>0.05	>0.05	>0.05	>0.05	>0.05	<0.05

组别	例数	性别(例，男/女)	年龄(岁，±s)	ARB/ACEI(例，是/否)	抗病毒药物(例，是/否)	术后输注红细胞(例，是/否)	AR(例，是/否)	血清肌酐(μmol/L，±s)
PTA组	16	11/ 5	49± 9	5/11	7/ 9	5/11	4/12	134±65
非PTA组	59	46/13	40±11	18/41	12/47	12/47	10/49	99±31
χ²/t值	－	χ²＝0.19	t＝0.83	χ²＝0.00	χ²＝2.51	χ²＝0.35	χ²＝0.14	t＝18.27
P值	－	>0.05	>0.05	>0.05	>0.05	>0.05	>0.05	<0.05

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