Rejection remains a common complication after liver transplantation, with an incidence of approximately 15%-25%, significantly impacting graft function and recipient survival. Basiliximab, a chimeric human-murine monoclonal antibody targeting the interleukin-2 receptor, is widely used for perioperative induction immunosuppression and individualized minimization strategies to reduce the risk of acute rejection and improve the safety of medication. To standardize and guide the clinical application of basiliximab in liver transplantation, the Branch of Organ Transplantation of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association have developed the "Chinese Guideline for Clinical Application of Basiliximab in Liver Transplant Recipients (2025 Edition)". This guideline summarize the clinical indications and key considerations for basiliximab administration, providing evidence-based, practice-oriented recommendations for its application in liver transplantation in China.

Organ transplantation is the most effective treatment for end-stage organ failure, and its long-term efficacy is directly influenced by the level of post-operative medication management. Studies have shown a high incidence of medication errors and medication-related problems among solid organ transplant recipients, which can significantly increase the risk of acute rejection and reduce graft survival. Clinical transplant pharmacists play a crucial role in promoting rational medication use and improving recipient outcomes. Currently, pharmaceutical care for solid organ transplantation in China is still in its early stages, lacking unified service standards and practical guidelines. To address this, we organized a national panel of medical and pharmaceutical experts in the field of organ transplantation. Based on the latest international advances and evidence-based findings, and through extensive solicitation of opinions using a modified Delphi method, we developed the Chinese Expert Consensus on Pharmaceutical Care for Solid Organ Transplant Recipients. This consensus centers on the entire process—pre-transplant, perioperative, and post-transplant—and puts forward 12 recommendations. It aims to systematically establish a standardized pharmaceutical care model, provide practical guidance for clinical pharmacists and transplant physicians, and ultimately enhance the long-term quality of life and graft survival rates for solid organ transplant recipients in China.

As an emerging technology, renal normothermic machine perfusion (NMP) not only improves the quality of donor organ preservation but also opens new avenues for the effective utilization of marginal kidneys. Based on relevant literature and clinical experience with renal NMP, this paper aims to establish standardized operational guidelines to provide practical instructions for the clinical application and promotion of this technique.

Biovigilance is a framework for the detection, collection and analysis of information on unexpected and untoward occurrences associated with the use of medical products of human origin (MPHO). Biovigilance and surveillance systems monitor adverse events, thereby promoting the implementation of preventive and corrective measures. The Council of Europe′s Guide to the Quality and Safety of Organs for Transplantation (8th Edition) provides a practical overview of this topic, discusses the establishment of effective biovigilance and surveillance systems, explores the practical steps of biovigilance, and analyzes the specific processes, methods, and importance of each link. It aims to provide theoretical support and practical guidance for medical workers, managers, and health management departments from various organ procurement organizations and transplant centers to optimize the surveillance system for organ transplantation, reduce risks, and ensure the safety and quality of transplantation.

To explore the construction of the prevention and control system of multidrug resistant organism (MDRO) infection in organ donation after the death of citizens.

Based on Donabedian′s " Structure Process Outcome" quality theory as the core theoretical framework, a preliminary draft of the system was developed through literature research and clinical practice. The Delphi method was used to determine the prevention and control system for MDRO infections in organ donation after the death of citizens. The Analytic Hierarchy Process was used to calculate the weights of each indicator, and a database was established using Excel 2019. Descriptive statistical analysis was conducted on the data using SPSS 22.00.

A total of 20 experts participated in the two rounds of inquiry, with a 100% positivity rate among the experts. The expert authority coefficients are 0.83 and 0.90, and the Kendall harmony coefficients are 0.540 and 0.568, respectively (all P<0.05). The coefficient of variation of each indicator is <0.25, and the average importance score ranges from 4.48 to 4.72 points, indicating that the indicator settings are scientific and the expert recognition is high. The final system for preventing and controlling organ donation after the death of citizens includes three primary indicators (structural indicators, process indicators, and outcome indicators), eight secondary indicators, and 33 tertiary indicators. The structural indicators cover three secondary indicators: quality control system, prevention and control facilities, and management standards. The process indicators include three secondary indicators: supplier maintenance, organ acquisition, and organ preservation. The outcome indicators involve the detection of MDRO and the implementation of prevention and control measures.

The prevention and control system of MDRO infection in organ donation after the death of citizens constructed in this study, demonstrates high validity and reliability, and can provide partial theoretical reference for the safe and high-quality implementation of the prevention and control of MDRO infection in organ donation.

To investigate the current status and influencing factors of social awareness regarding organ donation among Chinese citizens, providing theoretical and empirical support for initiatives aimed at increasing citizens′ llingness to donate organs after death.

From June 2023 to December 2024, a convenience sampling survey was conducted among residents of eight cities and counties in Hubei Province. The questionnaire collected demographic information, knowledge and attitudes toward organ donation, and willingness to donate. Participants were divided into two groups based on their willingness to donate. Independent sample t-tests were used for continuous variables, and chi-square tests were used for categorical variables. Variables showing statistically significant associations in univariate analysis were further included in the binary logistic regression model.

A total of 1, 432 questionnaires were collected, with 112 invalid responses excluded after data cleaning, resulting in 1, 320 valid responses for analyzed. Only 252 (19.1%) of participants expressed willingness to postmortem organ donation. Logistic regression showed that education level, recognition of legal issues surrounding donation, approval of China′s legal framework for donation, discomfort with the idea of postmortem donation, and concern about potential withdrawal of treatment independently influenced willingness.

Public willingness to donate organs remains generally low. Enhancing public awareness of organ donation laws and processes, fostering trust in the donation system, actively promoting the social value of organ donation, and addressing public concerns may effectively improve organ donation rates per million population in China.

Organ donation file is the key information of the whole process of organ donation, which is of vital importance to protect the rights and interests of donors and recipients. With the rapid development of organ donation and transplantation in China, the establishment of a scientific and standardized organ donation file management and quality control system has become particularly urgent. Based on the experience of a single center, this study explores the strategy and practice of the whole process management of organ donation files, guided by the Life Cyde Theory of Records, aiming to improve the quality of organ donation files and provide a referenceable experience for the management of organ donation files nationwide.

To investigate the impact of the AIDET communication model on the psychological resilience and donation willingness of potential organ donor families.

650 family members of organ donors from January 2017 to December 2023 were selected as the research subjects and randomly divided into an observation group and a control group using a random number table method, with 325 cases in each group. The control group received conventional communication intervention, while the observation group received AIDET communication intervention. Evaluate and compare the psychological resilience, communication effectiveness, willingness to donate, and communication satisfaction of two groups of family members.

After intervention, the psychological resilience scale (CD-RISC) scores of the observation group, including resilience, self-improvement, optimism, and total score, were higher than those of the control group (P all <0.05). The observation group had a higher awareness rate of donation knowledge, donation process, and donation precautions compared to the control group (P all <0.05). The donation willingness rate of the observation group was 44.9% (146/325), significantly higher than the control group′s 16.6% (54/325) (P<0.05). The satisfaction rate of communication in the observation group was 95.1% (309/325), significantly higher than that in the control group [70.2% (228/325)] (P<0.05).

The AIDET communication model has a good application effect on the families of potential organ donors, which can improve their psychological resilience, communication efficiency, donation willingness, and communication satisfaction.

To investigate the risk factors and treatment methods of portal vein thrombosis (PVT) after liver transplantation (LT) in adult liver cirrhosis recipients.

The clinical data of 596 adult cirrhosis patients undergoing LT in the Organ transplantation Center of Tianjin First Central Hospital from January 2018 to June 2022 were analyzed, and the overall cases were divided into PVT group (32 cases) and non-PVT group (564 cases) according to postoperative PVT. Unvariate and multivariate analysis were used to screen risk factors for PVT formation after LT and to compare survival rates between the two groups.

Out of the 596 LT recipients included in this study, the overall incidence of postoperative PVT was 5.37% (32/596). Multivariate analysis revealed that, the presence of large spontaneous portosystemic shunt (SPSS) (OR=6.716, 95%CI: 2.481-18.180), postoperative presence of portoshunt (OR=5.917, 95%CI: 1.785-19.615), preoperative grade Ⅲ-Ⅳ PVT (OR=8.368, 95%CI: 1.954-35.835) and cold ischemia time ≥10 h (OR=4.002, 95%CI: 1.183-13.537) were independent risk factors for PVT formation after LT(P<0.05). Among 32 recipients with PVT, 4 underwent surgical thrombectomy, 7 received interventional therapy, and 21 were treated with anticoagulant medications. After treatment, PVT resolved in 25 recipients, while 7 had stable PVT without clinical symptoms. A total of 5 deaths unrelated to PVT occurred. Survival analysis revealed that the 1-year, 2-year, and 3-year post-operative graft survival rates of the non-PVT group achieved 98.4%, 95.1%, and 93.6%, compared with 87.3%, 83.6%, and 78.4% in the PVT group. The difference was statistically significant (χ²=11.3, P<0.05).

The presence of large SPSS, grade Ⅲ-Ⅳ PVT, persistence of portosystemic shunt and cold ischemia time ≥10 h are independent risk factors for PVT formation after LT in adult patients with cirrhosis. For recipients of postoperative PVT formation, early diagnosis and treatment can achieve a better survival prognosis.

To investigate the impact of downgrading therapy during liver transplant waiting period on the prognosis of patients with acute-on-chronic liver failure (ACLF).

A retrospective analysis was performed on 344 ACLF patients who were on the liver transplantation waiting list at the Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, from January 2018 to August 2024. The cohort included 102 patients who did not undergo transplantation and 242 patients who completed liver transplantation. Based on the Chinese Group on the Study of Severe Hepatitis B-ACLF guideline, ACLF was classified into grades 1 to 3. For the transplant group, the last examination prior to liver transplantation was used as the endpoint for scoring, while for the non-transplant group, the last examination before discharge or prior to death was used as the scoring endpoint. In addition to assessing changes in ACLF grades, an evaluation method based on "organ failure + organ injury" was incorporated. After downgrading therapy, patients were divided into a successful downgrading group and a failed downgrading group. Normally distributed continuous variables were compared using the independent-samples t-test; non-normally distributed continuous variables were compared using the Mann-Whitney U test. Categorical variables were compared using the chi-square test. Kaplan-Meier survival curves were constructed, and comparisons were made using the log-rank test. A P-value of <0.05 was considered statistically significant.

The differences in γ-glutamyltransferase, serum glucose, prothrombin time, serum creatinine, the proportion of patients with renal failure, international normalized ratio, the proportion of patients with coagulopathy, and the model for end-stage liver disease score between the transplant and non-transplant groups were statistically significant (Z/χ²=-2.315, -2.260, -4.299, -2.434, 4.428, -5.263, 13.021, and -5.282, all P<0.05). At the time of outcome events, 225 patients achieved successful downgrading therapy (successful downgrading group), including 193 in the transplant group and 32 in the non-transplant group. A total of 119 patients experienced failure of downgrading therapy (failed downgrading group), including 49 cases in the transplant group and 70 cases in the non-transplant group. The 1-year cumulative survival rate of ACLF patients in the successful downgrading group (n=225) was higher than that in the failed downgrading group (n=119) (χ²=81.95, P<0.05). Further analysis showed that in the non-transplant group, the 1-year cumulative survival rate of ACLF patients in the successful downgrading group (n=32) was higher than that in the failed downgrading group (n=70) (χ²=4.28, P<0.05). However, in the transplant group, there was no statistically significant difference in the 1-year cumulative survival rate between the successful downgrading group (n=193) and the failed downgrading group (n=49) (χ²=2.62, P>0.05).

Successful downgrading can improve the overall short-term prognosis of all patients with ACLF and the survival rate of non-transplanted patients, and extend the liver transplant waiting period.

To explore the latent profiles of lung transplant recipients′ quality of life, as well as the traits and contributing variables of different quality of life categories.

The study included 300 lung transplant recipients who visited Wuxi People′s Hospital for follow-up outpatient visits between January and December 2022. The lung transplant quality of life survey (LT-QOL) and a general information questionnaire were used in the questionnaire surveys. The Kruskal-Wallis H test was used to compare groups for continuous data, while the chi-square test or Fisher′s exact probability test was used for comparison between groups for categorical data. The factor scores for every dimension were determined using the lavaan package. The mclust and tidyLPA programs were used to conduct latent profile analysis (LPA). The nnet software was used to perform logistic regression on factors with P<0.10 in univariate analysis. The threshold for statistical significance was set at P<0.05.

A total of 300 questionnaires were distributed, with 5 invalid responses excluded, yielding a valid response rate of 98.3% (295/300). LPA was conducted based on factor scores across the LT-QOL′s 11 domains, the 295 recipients were categorised into high quality of life-quality of life satisfaction group (n=181), moderate quality of life-prominent diarrhoea symptoms group (n=34), moderate quality of life-prominent sexual function issues group (n=40), low quality of life-poor overall perception group (n=40). Univariate analysis revealed statistically significant differences in age, pathoglycemia, and dyslipidaemia among recipients in the above four groups (H/χ²=10.135, 15.599 and 14.527 respectively, all P<0.05). Multivariate logistic regression analysis revealed that the age, unplanned readmission frequency, pathoglycemia, and dyslipidaemia were statistically significant factors influencing quality of life categories among lung transplant recipients (all P<0.05).

Quality of life among lung transplant recipients exhibits marked heterogeneity. Nursing staff may develop targeted intervention strategies based on the characteristics of their respective quality of life categories to enhance their quality of life and overall health status.

Bibliometric and visualization analyses of the literature in the field of transplant pharmacy were conducted to inform the development of transplant pharmacist teams, advance transplant pharmacy research, and enhance transplant pharmacy service standards in China.

Publications related to transplantation and pharmacy were searched in the Web of Science Core Collection database from the establishment of the database to December 2024. Bibliometric method was used to analyze the annual publication output, citation frequency, as well as the countries, authors, and institutions. CiteSpace software and VOSviewer were used to detect bursts and clusters of keywords and citations, in order to analyze the current status and hotspots of the field.

A total of 3 168 articles were included in this study, with the earliest publication dating back to 1992. The highest number of publications occurred in 2022 (n=273). The total number of citations was 66, 740, with the highest figure in 2024 reaching 6 116. The United States had the most publications (n=1 659) and maintained the strongest collaborations with other countries. A total of 3 077 institutions participated in the publications, with the Pennsylvania Commonwealth System of Higher Education (n=176) ranking first in publication volume. A total of 16 408 authors contributed to the publications, with Taber DJ (n=78) being the most prolific author. The top ten most intense emergent citations sustained their pre-eminence for a period of 3 to 4 years. The most significant emergent citation was "Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report" by Spanish scholar Brunet M in 2019, with a citation intensity of 37.78. Sixty keywords were subjected to cluster analysis, forming three distinct clusters. These clusters focus on three key areas: assessment of therapeutic efficacy in organ transplantation, immunotherapy in organ transplantation, and the pharmacokinetics and genomics of immunosuppressive agents.

By visualizing and analyzing the research in the field of transplant pharmacy, this study provides guidance for the further development of transplant pharmacy, the improvement of pharmacy services, and the conduct of related research in China in the future.

Spinal cord injury (SCI) is a severe traumatic lesion of the central nervous system, in which patients present with sensory, motor and autonomic nerve dysfunction below the level of the injury. Neural stem cells (NSCs) possess robust self-renewal capacity, multi-directional differentiation potential, and unique microenvironment regulatory functions. This article focuses on elaborating the mechanisms of NSCs transplantation for the treatment of SCI. Studies have shown that NSCs can not only differentiate into nerval cells, but also play a crucial role in neuroprotection, axonal regeneration, and neural circuit reconstruction through complex intercellular interactions and microenvironment regulatory mechanisms. However, NSCs transplantation for the treatment of SCI still faces challenges such as low survival rate of transplanted cells, insufficient efficiency of directed differentiation, and obstruction by glial scarring. Future studies may integrate genetic technologies and utilize biomaterials to enhance cell survival capacity and improve the damaged microenvironment, thereby advancing the researches on NSCs transplantation for SCI from basic studies to clinical application and bringing new hope to patients with SCI.