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中华移植杂志(电子版) ›› 2025, Vol. 19 ›› Issue (05) : 285 -293. doi: 10.3877/cma.j.issn.1674-3903.2025.05.001

标准与指南

中国肝移植受者巴利昔单抗临床应用指南(2025版)
中华医学会器官移植学分会肝移植学组, 中国医师协会器官移植医师分会   
  1. 1. 610041 成都,四川大学华西医院
    2. 310006 杭州,国家肝脏移植技术医疗质量控制中心
  • 收稿日期:2025-09-11 出版日期:2025-10-25
  • 基金资助:
    四大慢病重大专项(2023ZD0502400); 国家科技重大专项(2022YFC2304705); 国家自然科学基金(82270691、82570743、82300663、82500725); 四川大学华西医院学科卓越发展1·3·5工程项目(ZYGD24002)

Chinese guideline for clinical application of basiliximab in liver transplant recipients(2025 edition)

Liver Transplantation Group, Branch of Organ Transplantation of Chinese Medical Association, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association   

  1. 1. West China Hospital of Sichuan University, Chengdu 610041, China
    2. National Center for Healthcare Quality Management of Liver Transplant, Hangzhou 310006, China
  • Received:2025-09-11 Published:2025-10-25
引用本文:

中华医学会器官移植学分会肝移植学组, 中国医师协会器官移植医师分会. 中国肝移植受者巴利昔单抗临床应用指南(2025版)[J/OL]. 中华移植杂志(电子版), 2025, 19(05): 285-293.

Liver Transplantation Group, Branch of Organ Transplantation of Chinese Medical Association, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association. Chinese guideline for clinical application of basiliximab in liver transplant recipients(2025 edition)[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2025, 19(05): 285-293.

排斥反应是肝移植术后常见并发症,发生率为15%~25%,严重影响移植肝功能与受者生存。巴利昔单抗是一种针对白介素-2受体的人-鼠嵌合型单克隆抗体,常用于肝移植围手术期的免疫诱导与个体化减毒方案,以降低急性排斥反应风险并提高用药安全性。为规范和指导巴利昔单抗在肝移植受者中的应用,中华医学会器官移植学分会肝移植学组和中国医师协会器官移植医师分会组织全国移植专家,结合国内外相关文献、循证医学证据和我国临床实践经验,制订《中国肝移植受者巴利昔单抗临床应用指南(2025版)》。该指南重点阐述巴利昔单抗的作用机制、临床应用场景、药物使用注意事项等方面,为我国巴利昔单抗在肝移植受者中的应用提供科学的指导和参考。

Rejection remains a common complication after liver transplantation, with an incidence of approximately 15%-25%, significantly impacting graft function and recipient survival. Basiliximab, a chimeric human-murine monoclonal antibody targeting the interleukin-2 receptor, is widely used for perioperative induction immunosuppression and individualized minimization strategies to reduce the risk of acute rejection and improve the safety of medication. To standardize and guide the clinical application of basiliximab in liver transplantation, the Branch of Organ Transplantation of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association have developed the "Chinese Guideline for Clinical Application of Basiliximab in Liver Transplant Recipients (2025 Edition)". This guideline summarize the clinical indications and key considerations for basiliximab administration, providing evidence-based, practice-oriented recommendations for its application in liver transplantation in China.

表1 2009牛津大学证据分级与推荐意见强度分级标准
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