Chinese guideline for clinical application of basiliximab in liver transplant recipients(2025 edition)

doi:10.3877/cma.j.issn.1674-3903.2025.05.001

Abstract

Abstract:

Rejection remains a common complication after liver transplantation, with an incidence of approximately 15%-25%, significantly impacting graft function and recipient survival. Basiliximab, a chimeric human-murine monoclonal antibody targeting the interleukin-2 receptor, is widely used for perioperative induction immunosuppression and individualized minimization strategies to reduce the risk of acute rejection and improve the safety of medication. To standardize and guide the clinical application of basiliximab in liver transplantation, the Branch of Organ Transplantation of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association have developed the "Chinese Guideline for Clinical Application of Basiliximab in Liver Transplant Recipients (2025 Edition)". This guideline summarize the clinical indications and key considerations for basiliximab administration, providing evidence-based, practice-oriented recommendations for its application in liver transplantation in China.

Key words: Liver Transplantation, Basiliximab, Immunosuppressive induction, Rejection

Liver Transplantation Group, Branch of Organ Transplantation of Chinese Medical Association, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association. Chinese guideline for clinical application of basiliximab in liver transplant recipients(2025 edition)[J]. Chinese Journal of Transplantation(Electronic Edition), 2025, 19(05): 285-293.

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References 79

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推荐强度	证据级别	定义
A	1a	RCT的系统评价
	1b	结果可信区间小的RCT
	1c	显示"全或无效应"的任何证据
B	2a	队列研究的系统评价
	2b	单个队列研究(包括低质量的RCT，如失访率>20%)
	2c	基于患者结局的研究
	3a	病例对照研究的系统评价
	3b	单个病例对照研究
C	4	病例系列报道、低质量队列研究、低质量病例对照研究
D	5	专家意见(即无临床研究支持的仅依据基础研究或临床研究的推测)

推荐强度	证据级别	定义
A	1a	RCT的系统评价
	1b	结果可信区间小的RCT
	1c	显示"全或无效应"的任何证据
B	2a	队列研究的系统评价
	2b	单个队列研究(包括低质量的RCT，如失访率>20%)
	2c	基于患者结局的研究
	3a	病例对照研究的系统评价
	3b	单个病例对照研究
C	4	病例系列报道、低质量队列研究、低质量病例对照研究
D	5	专家意见(即无临床研究支持的仅依据基础研究或临床研究的推测)

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