Severe donor organ shortage has greatly restricted the clinical application of organ transplantation. In China, the utilization of extended criteria donor (ECD) grafts, including donation after cardiac death (DCD) and steatotic grafts have increased year by year, leading to a significantly higher incidence of early allograft dysfunction and other post-transplant complications, as well as a significantly reduced overall survival. To standardize the clinical use of ECD grafts and improve recipients′ outcome, the Liver Transplantation Group, Branch of Organ Transplantation of Chinese Medical Association and Organ Transplantation Physicians of the Chinese Medical Doctor Association have organized experts to summarize and discuss the clinical diagnosis and management of ECD grafts in China by combining the evidence-based medical basis and Chinese clinical practice experience, and by drawing on the relevant domestic and international literature, thereby developed the "Chinese Clinical Practice Guidelines for Extended Criteria Donor Grafts in Liver Transplantation." This guideline addressed a series of recommendations in a scientific and standardized way in terms of donor-recipient status and risk prevention, regarding to DCD grafts, steatotic grafts, small-for-size grafts, elderly donor grafts, and hepatitis B virus-infected grafts. Its purpose is to establish a scientific evaluation and application framework for ECD grafts, balance the risks of organ utilization and survival benefits, and ultimately enhance overall survival and life quality of liver transplant recipients in China.