To summarize the experience of renal transplantation that donor kidneys from C-Ⅲdonation after cardiac death (DCD) with history of cardiopulmonary resuscitation.

The clinical data of donors of C-Ⅲ DCD and corresponding recipients of renal transplantation in the 303th Hospital of PLA from January 2013 to December 2015 was retrospectively summarized. Recipients were divided into two groups according to history of cardiopulmonary resuscitation of donor kidneys (cardiopulmonary resuscitation group and control group). A total of 304 recipients were selected for the study, there were 76 cases in cardiopulmonary resuscitation group (48 cases of donors) and 228 cases in control group (143 cases of donors). The χ² test was used to compare the usage rate of extracorporeal membrane oxygenation (ECMO) and Lifeport, proportion of panel reactive antibody (PRA) of recipients 3 months after operation, incidence rate of delayed graft function (DGF) and acute rejection (AR) between the two groups; the Wilcoxon test was used to compare serum creatinine of donors before donor organ procurement and time consuming for serum creatinine felling to 442 umol/L of recipients between the two groups; the t test was used to compare cold and warm ischemia time of donor kidneys, age of recipients, serum creatinine of recipients 3 months after operation between the two groups. Statistical significance was approved when P<0.05.

The donors and the recipients were matched in same ABO blood groups typing. HLA typing in cardiopulmonary resuscitation group: 5 locuses mismatch (4 cases), 4 locuses mismatch (23 cases), 3 locuses mismatch (39 cases), 2 locuses mismatch (10 cases). HLA typing in control group: 5 locuses mismatch (17 cases), 4 locuses mismatch (89 cases), 3 locuses mismatch (104 cases), 2 locuses mismatch (16 cases), 1 locuses mismatch (2 cases). The serum creatinine of donors before donor organ procurement between cardiopulmonary resuscitation group and control group were 184 mol/L (30-353 mmol/L) and 88 mol/L (25-407 mmol/L), the difference was statically significant (U=-2.760, P<0.05). No significant difference was found between the two groups in other indexes which were mentioned above (P all>0.05).

The curative effect of renal transplantation that donor kidneys from C-Ⅲ donation after DCD with history of cardiopulmonary resuscitation is similar with those without history of cardiopulmonary resuscitation baseing on active and appropriate measures taken to donors. Lifeport may play a important role in the process.