To analyzed changes of procalcitonin (PCT) and procalcitonin clearance rate (PCTc) in patient with different outcomes after liver autotransplantation.

Thirty-two liver autotransplantation recipients admitted into ICU after transplantation from October 2015 to June 2017 were included in this study, all the recipients were divided into in infection group (18 cases) and non-infection group (14 cases) according to the results of etiological examination.The general clinical information and serum PCT value of the first to ninth day after transplantation were collected, and the PCTc of the third, fifth, seventh and ninth day after transplantation were counted. Two independent sample t-test was used to compare the age, APACHEⅡ scores, hospital stay and ICU stay of the recipients of the 2 groups. Rank-sum test was used to compare the serum PCT and PCTc of the 2 groups. Chi-square test was used to compare the gender of the 2 groups. Receiver operating characteristic (ROC) curve was used to evaluted the prognosis of recipients of the 2 groups. P<0.05 was considered statistically significant.

The median serum PCT value of the third, the fifth, the seventh and the ninth day after transplantation between infection group and non-infection group were [13.27(6.25-26.85)] and [5.69(5.21-14.25)], [20.57(15.65-35.25)] and [5.65(4.52-6.56)], [25.88(20.36-42.65)] and [5.93(4.72-13.65)], [30.31(22.21-50.36)] and [6.47(0.94-9.25)] ng/mL, which all had statistical sinificance (Z=-2.166, -3.305, -3.400, -3.837, P all<0.05). The median PCTc of the seventh and the ninth day after transplantation between infection group and non-infection group were -195%(-548% to -70%) and -23%(-93% to 55%), -223%(-645% to -89%) and -39%(-96% to 89%), which all had statistical sinificance (Z=-3.001, -3.153, P all<0.05). The areas under the ROC curve of the third, the fifth, the seventh and the ninth day after transplantation were 0.708(95%CI: 0.517-0.900, P<0.05), 0.778(95%CI: 0.614-0.942, P<0.05), 0.813 (95%CI: 0.665-0.962, P<0.05), 0.829 (95%CI: 0.689-0.970, P<0.05), and the area under the ROC curve of the ninth day after transplantation was the largest. When the cut-off value was -78.04%, sensitivity was 85.7% and specificity was 73.4%.

The increased levels of PCT in patients after liver autotransplantation was associated the poor control of infection, keeping observing the dynamic change of PCT and PCTc after transplantation may provide guiding significance for illness condition assessment.