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Chinese Journal of Transplantation(Electronic Edition) ›› 2020, Vol. 14 ›› Issue (01): 58-61. doi: 10.3877/cma.j.issn.1674-3903.2020.01.015

Special Issue:

• Review • Previous Articles     Next Articles

The mechanisms of gastrointestinal symptoms induced by immunosuppressive agents in kidney transplant recipients

Wenbin Song1, Kuifen Ma2, Xingde Li1, Yang Zhang1, Cangsang Song1,()   

  1. 1. Department of Pharmacy, Calmette Hospital Affiliated to Kunming Medical University, Kunming First People′s Hospital, Kunming 650224, China
    2. Department of Pharmacy, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
  • Received:2019-10-28 Online:2020-02-25 Published:2020-02-25
  • Contact: Cangsang Song
  • About author:
    Corresponding author: Song Cangsang, Email:

Abstract:

Tacrolimus and mycophenolate mofetil are the main cause of gastrointestinal symptoms in kidney transplant recipients. The possible induced mechanisms include the increase of drug exposure and inhibition on gut associated lymph tissue. Tacrolimus exposure is associated with the genetic polymorphisms of CYP 3A4, 3A5 and P-glycoprotein, and changes in the gastrointestinal function and abundance of intestinal bacterial flora, and so on. Increasing tacrolimus exposure promotes gastrointestinal motility and mycophenolic acid (MPA) absorption. MPA induced gastrointestinal side effects is associated with its antiproliferative effect on the basal epithelial cells of the gastrointestinal tract.

Key words: Kidney transplantation, Immunosuppressive agents, Diarrhea, Tacrolimus, P-glycoprotein, Mycophenolic acid, Gastrointestinal complications

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