Prognostic factors of liver transplantation for patients with drug induced acute liver failure

doi:10.3877/cma.j.issn.1674-3903.2020.04.017

Abstract

Abstract:

Acute liver failure (ALF) secondary to drug induced liver injury (DILI) is a rare and severe consequence of hepatocyte injury, which leads to a rapid-onset elevation of aminotransferases, hepatic encephalopathy, coagulopathy and so on. The main causes of DILI related-ALF can be classified to acetaminophen(APAP)-related ALF (mainly for acetaminophen) and idiosyncratic DILI (herbal and dietary supplements and so on). APAP-related ALF presents with a hyperacute liver injury and more than 75% of patients can survive without liver transplantation, while idiosyncratic DILI-related ALF develops more slowly, approximately 60% of patients require liver transplantation. Establishment of a prediction model based on the causes and clinical parameters, will help to recognize the nature history of DILI-related ALF and work out timely treatment strategies focusing on liver transplantation, finally to improve the overall survival.

Key words: Drug induced liver injury, Acute liver failure, Liver Transplantation, Prognosis, Predictor

Chaofeng Ding, Sheng Gao, Shusen Zheng. Prognostic factors of liver transplantation for patients with drug induced acute liver failure[J]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(04): 268-271.

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URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2020.04.017

https://zhyzzz.cma-cmc.com.cn/EN/Y2020/V14/I04/268

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