Advance in study on reactive oxygen species mediated hepatic ischemia-reperfusion injury mechanisms

doi:10.3877/cma.j.issn.1674-3903.2020.05.012

Abstract

Abstract:

Hepatic ischemia-reperfusion injury(HIRI)is a complex pathophysiological process involving oxidative stress, inflammatory response, calcium overload and other mechanisms. Reactive oxygen species play an important role in all these process of HIRI. However, with the development in the study of preischemia intervention, reactive oxygen species may be involved in the protection of hepatocytes through hypoxia inducible factor, phosphoinositide 3-kinase/protein kinase B pathway and mitogen-activated protein kinases pathways. This paper reviews the damage and potential protection of reactive oxygen species in HIRI.

Key words: Liver, Hepatic ischemia-reperfusion injury, Reactive oxygen species, Liver transplantation

Jiamin Zeng, Xuyong Sun, Jianhui Dong. Advance in study on reactive oxygen species mediated hepatic ischemia-reperfusion injury mechanisms[J]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(05): 319-323.

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https://zhyzzz.cma-cmc.com.cn/EN/Y2020/V14/I05/319

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