Research progress on the protective mechanism of mesenchymal stem cells on islet grafts

doi:10.3877/cma.j.issn.1674-3903.2020.06.013

Abstract

Abstract:

Islet transplantation is considered to be the most effective method for the treatment of type 1 diabetes and some type 2 diabetes, but its clinical efficacy needs to be further improved. A large number of literatures have reported that mesenchymal stem cells (MSCs) have a protective effect on islet grafts, but its specific mechanism is unclear. This article summarizes the reported protective effects of MSCs on islet grafts into four aspects: nutritional effects, promotion of revascularization, immune regulation, and regulation of endoplasmic reticulum stress.

Key words: Mesenchymal stem cells, Islet, Islet transplantation, Diabetes

Feng Li, Xiaohang Li, Jialin Zhang. Research progress on the protective mechanism of mesenchymal stem cells on islet grafts[J]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(06): 397-400.

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URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2020.06.013

https://zhyzzz.cma-cmc.com.cn/EN/Y2020/V14/I06/397

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References 41

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保护作用	具体作用方式	参考文献
营养作用	提供细胞外基质	12-14
	线粒体转移	11
	分泌营养细胞因子	10, 13, 15
	分泌细胞外囊泡	19-20
促进再血管化	分泌促血管生成细胞因子	23-24, 26
	直接分化为血管组分	22
免疫调节	促巨噬、树突状等细胞表型转化	28-29
	调节T、B等细胞数量和比例	30-32

调控内质网应激	分泌SDF-1上调Myc	39
	Micro RNA-21	41

保护作用	具体作用方式	参考文献
营养作用	提供细胞外基质	12-14
	线粒体转移	11
	分泌营养细胞因子	10, 13, 15
	分泌细胞外囊泡	19-20
促进再血管化	分泌促血管生成细胞因子	23-24, 26
	直接分化为血管组分	22
免疫调节	促巨噬、树突状等细胞表型转化	28-29
	调节T、B等细胞数量和比例	30-32

调控内质网应激	分泌SDF-1上调Myc	39
	Micro RNA-21	41

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