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Chinese Journal of Transplantation(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (02): 119-123. doi: 10.3877/cma.j.issn.1674-3903.2021.02.012

• Review • Previous Articles     Next Articles

Mechanism of macrophages involved in hepatic ischemia-reperfusion injury

Bo Yu1, Tao Qiu1,()   

  1. 1. Department of Organ Transplanation, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Received:2020-12-27 Online:2021-04-25 Published:2021-07-30
  • Contact: Tao Qiu

Abstract:

Hepatic ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in trauma, shock, liver surgery and liver transplantation. It involves a variety of molecular mechanisms and is the result of the interaction of various cells. Severe liver IRI often leads to liver dysfunction, even liver failure. Until now, the mechanism of liver IRI has not been fully elucidated. In recent years, macrophages have been found to play an important role in liver IRI. This paper aims to summarize the research progress of macrophages in IRI in recent years, and provide some ideas for further research.

Key words: Ischemia-reperfusion injury, Liver, Macrophage

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