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Chinese Journal of Transplantation(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (05): 317-320. doi: 10.3877/cma.j.issn.1674-3903.2021.05.013

• Review • Previous Articles    

Research progress of ibrutinib in the treatment of chronic graft-versus-host disease

Heng Liu1, Tao Wu1,()   

  1. 1. Department of Hematology, the 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, China
  • Received:2021-02-10 Online:2021-10-25 Published:2022-01-29
  • Contact: Tao Wu

Abstract:

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is potentially curative for a number of hematologic conditions, both malignant and nonmalignant. However, its success can be limited by the development of graft-versus-host disease. Chronic graft-versus-host disease (cGVHD) is a major cause for late non-relapse-related death in patients undergoing allo-HSCT, and seriously affects their quality of life. Resulting from its good effect on cGVHD, ibrutinib became the first FDA-approved therapy for the treatment of cGVHD in adult patients after failure of one or more lines of systemic therapy. In this review, we describe the progress of ibrutinib identified as potential cGVHD therapy.

Key words: Ibrutinib, Chronic graft-versus-host disease, Allogeneic hematopoietic stem cell transplantation

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