The progress of immunosuppressive therapy for IgA nephropathy patients underwent kidney transplantation

doi:10.3877/cma.j.issn.1674-3903.2021.06.008

Abstract

Abstract:

IgA nephropathy (IgAN) is the most common form of glomerulonephritis, and current evidence suggests that IgAN is the result of multiple sequential pathogenic hits and may led to end stage renal disease after diagnosis. However, IgAN has a strong tendency to recur in graft after kidney transplantation. In order to avoid graft loss due to IgAN recurrence, it is particularly important to provide sustained treatment for patients after kidney transplantation. Compared with the management of primary IgAN, not only can patients maintain previous treatment of primary IgAN after kidney transplantation, but also a wider range of immunosuppressive is available. The aim of this review is to describe the pathogenesis of IgAN and discuss the therapeutic mechanism of commonly used immunosuppressants for recurrent IgAN after kidney transplantation.

Key words: Kidney transplantation, IgA nephropathy, Immunosuppressant, Recurrence

Caitao Dong, Dawei Zhou, Juntao Liang, Qifa Ye. The progress of immunosuppressive therapy for IgA nephropathy patients underwent kidney transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(06): 365-369.

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References 38

1	Lai KN. Pathogenesis of IgA nephropathy[J]. Nat Rev Nephrol, 2012, 8(5)：275-283.
2	Sofue T, Suzuki H, Ueda N, et al. Post-transplant immunoglobulin A deposition and nephropathy in allografts[J]. Nephrology (Carlton), 2018, 23(Suppl 2)：4-9.
3	Wyld ML, Chadban SJ. Recurrent IgA nephropathy after kidney transplantation[J]. Transplantation, 2016, 100(9)：1827-1832.
4	Nijim S, Vujjini V, Alasfar S, et al. Recurrent IgA nephropathy after kidney transplantation[J]. Transplant Proc, 2016, 48(8)：2689-2694.
5	Moroni G, Belingheri M, Frontini G, et al. Immunoglobulin A nephropathy. Recurrence after renal transplantation[J]. Front Immunol, 2019, 10：1332.
6	Matsukuma Y, Masutani K, Tsuchimoto A, et al. Effect of steroid pulse therapy on post-transplant immunoglobulin A nephropathy[J]. Nephrology (Carlton), 2018, 23(Suppl 2)：10-16.
7	Lionaki S, Panagiotellis K, Melexopoulou C, et al. The clinical course of IgA nephropathy after kidney transplantation and its management[J]. Transplant Rev (Orlando), 2017, 31(2)：106-114.
8	Cerutti A. The regulation of IgA class switching[J]. Nat Rev Immunol, 2008, 8(6): 421-434.
9	Yeo SC, Cheung CK, Barratt J. New insights into the pathogenesis of IgA nephropathy[J]. Pediatr Nephrol, 2018, 33(5)：763-777.
10	Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy[J]. J Am Soc Nephrol, 2011, 22(10)：1795-1803.
11	Coppo R. Biomarkers and targeted new therapies for IgA nephropathy[J]. Pediatr Nephrol, 2017, 32(5)：725-731.
12	Li W, Peng X, Liu Y, et al. TLR9 and BAFF: their expression in patients with IgA nephropathy[J]. Mol Med Rep, 2014, 10(3): 1469-1474.
13	McCarthy DD, Kujawa J, Wilson C, et al. Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy[J]. J Clin Invest, 2011, 121(10)：3991-4002.
14	Samy E, Wax S, Huard B, et al. Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases[J]. Int Rev Immunol, 2017, 36(1)：3-19.
15	Martín-Penagos L, Benito-Hernández A, San Segundo D, et al. A proliferation-inducing ligand increase precedes IgA nephropathy recurrence in kidney transplant recipients[J]. Clin Transplant, 2019, 33(4)：e13502.
16	Sonoda Y, Gohda T, Suzuki Y, et al. Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy[J]. PLoS One, 2015, 10(4): e0122212.
17	Zhang Z, Jiang SM, Ma YP, et al. Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy[J]. Mol Cell Biochem, 2019, 453(1-2): 103-110.
18	Lim WH, Shingde M, Wong G. Recurrent and de novo glomerulonephritis after kidney transplantation[J]. Front Immunol, 2019, 10: 1944.
19	Malhotra PS, Jorna T, Bhandari S. Treatment of immunoglobulin A nephropathy recurrence post-renal transplant[J]. Transplant Proc, 2018, 50(1): 165-167.
20	Courtney AE, McNamee PT, Nelson WE, et al. Does angiotensin blockade influence graft outcome in renal transplant recipients with IgA nephropathy？[J]. Nephrol Dial Transplant, 2006, 1(12): 3550-3554.
21	Muto M, Manfroi B, Suzuki H, et al. Toll-like receptor 9 stimulation induces aberrant expression of a proliferation-inducing ligand by tonsillar germinal center B cells in IgA nephropathy[J]. J Am Soc Nephrol, 2017, 28(4): 1227-1238.
22	Koshino K, Ushigome H, Sakai K, et al. Outcome of tonsillectomy for recurrent IgA nephropathy after kidney transplantation[J]. Clin Transplant, 2013, 27(Suppl 26): 22-28.
23	Hirano K, Amano H, Kawamura T, et al. Tonsillectomy reduces recurrence of IgA nephropathy in mesangial hypercellularity type categorized by the Oxford classification[J]. Clin Exp Nephrol, 2016, 20(3): 425-432.
24	Katsumata H, Yamamoto I, Komatsuzaki Y, et al. Successful treatment of recurrent immunoglobulin a nephropathy using steroid pulse therapy plus tonsillectomy 10 years after kidney transplantation: a case presentation[J]. BMC Nephrol, 2018, 19(1): 64.
25	Leeaphorn N, Garg N, Khankin EV, et al. Recurrence of IgA nephropathy after kidney transplantation in steroid continuation versus early steroid-withdrawal regimens: a retrospective analysis of the UNOS/OPTN database[J]. Transpl Int, 2018, 31(2): 175-186.
26	Cordeiro Cabral DB, de Sandes-Freitas TV, Medina-Pestana JO, et al. Clinical features, treatment and prognostic factors of post-transplant immunoglobulin A nephropathy[J]. Ann Transplant, 2018, 23：166-175.
27	Zagkotsis G, Vourlakou C, Paraskevopoulos A, et al. Recurrence of crescentic IgA nephropathy after renal transplantation[J]. CEN Case Rep, 2018, 7(2): 268-273.
28	Messina M, di Vico MC, Ariaudo C, et al. Treatment protocol with pulse and oral steroids for IgA nephropathy after kidney transplantation[J]. J Nephrol, 2016, 29(4): 575-583.
29	Berthoux F, El Deeb S, Mariat C, et al. Antithymocyte globulin (ATG) induction therapy and disease recurrence in renal transplant recipients with primary IgA nephropathy[J]. Transplantation, 2008, 85(10): 1505-1507.
30	Lee KW, Kim KS, Lee JS, et al. Impact of induction immunosuppression on the recurrence of primary IgA nephropathy[J]. Transplant Proc, 2019, 51(5): 1491-1495.
31	Ziswiler R, Steinmann-Niggli K, Kappeler A, et al. Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis[J]. J Am Soc Nephrol, 1998, 9(11): 2055-2066.
32	Von Visger JR, Gunay Y, Andreoni KA, et al. The risk of recurrent IgA nephropathy in a steroid-free protocol and other modifying immunosuppression[J]. Clin Transplant, 2014, 28(8): 845-854.
33	Tian J, Wang Y, Liu X, et al. Rapamycin ameliorates IgA nephropathy via cell cycle-dependent mechanisms[J]. Exp Biol Med (Maywood), 2015, 240(7): 936-945.
34	Tian J, Wang Y, Zhou X, et al. Rapamycin slows IgA nephropathy progression in the rat[J]. Am J Nephrol, 2014, 39(3): 218-229.
35	Chancharoenthana W, Townamchai N, Leelahavanichkul A, et al. Rituximab for recurrent IgA nephropathy in kidney transplantation: a report of three cases and proposed mechanisms[J]. Nephrology (Carlton), 2017, 22(1): 65-71.
36	Lafayette RA, Canetta PA, Rovin BH, et al. A randomized, controlled trial of rituximab in IgA nephropathy with proteinuria and renal dysfunction[J]. J Am Soc Nephrol, 2017, 28(4)：1306-1313.
37	Wang Z, Yu C, Zhou LN, et al. Effects of tripterygium wilfordii induction therapy to IgA nephropathy patients with heavy proteinuria[J]. Biol Pharm Bull, 2017, 40(11)：1833-1838.
38	Li H, Kong D, Xu Y, et al. Tripterygium wilfordii inhibits tonsillar IgA production by downregulating IgA class switching in IgA nephropathy[J]. Oncotarget, 2017, 8(65): 109027-109042.

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