Research progress on the mechanism and adverse outcome of hyperglycemia in the neohepatic phase of liver transplantation

doi:10.3877/cma.j.issn.1674-3903.2022.02.011

Abstract

Abstract:

Severe hyperglycemia often occurs in the neohepatic phase of liver transplantation, and its risk factors include recipient factors, donor liver factors and exogenous factors. The main pathophysiological mechanisms of neohepatic hyperglycemia include insulin resistance, ischemia-reperfusion injury, inflammatory reaction and oxidative stress, which often result in poor prognosis. At present, there is still a lack of consensus on the diagnosis, management and prevention of neohepatic hyperglycemia in liver transplantation. Therefore, it is an urgent clinical problem to clarify glucose management objectives, formulate specific glucose management programs and optimize intraoperative glucose management. This article reviews the risk factors, pathophysiological mechanism and adverse prognosis of neohepatic hyperglycemia in liver transplantation.

Key words: Liver transplantation, Neohepatic phase, Hyperglycemia, Mechanism, Prognosis

Lei Cui, Yi Duan, Zhifeng Gao, Huan Zhang. Research progress on the mechanism and adverse outcome of hyperglycemia in the neohepatic phase of liver transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(02): 114-118.

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