Research progress on prognosis of pediatric acute liver failure

doi:10.3877/cma.j.issn.1674-3903.2022.03.010

Abstract

Abstract:

Pediatric acute liver failure (PALF) is a kind of disease with high mortality rate, characterized by severe liver dysfunction and coagulation disorder with or without encephalopathy. liver transplantation improved the prognosis of PALF. The identification of poor outcome in PALF is necessary for clinical decision. The review concludes the recent prognostic factors of PALF, the prognostic model and the biomarkers. No optimal prognostic model has been developed for PALF so far, and further high-quality studies on larger cohorts are needed to determine the prognostic factors of PALF.

Key words: Acute liver failure, Pediatrics, Prognosis, Assessment, Liver transplantation

Junwen Mao, Yuanmei Kong, Xiaoyuan Zhang, Yanlan Fang. Research progress on prognosis of pediatric acute liver failure[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(03): 179-182.

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URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2022.03.010

https://zhyzzz.cma-cmc.com.cn/EN/Y2022/V16/I03/179

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References 31

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LIU评分(PT)	LIU评分(INR)	推荐级别
0～ 43	0～210	弱
44～ 84	211～295	中
85～138	296～367	强
≥139	≥368	很强

LIU评分(PT)	LIU评分(INR)	推荐级别
0～ 43	0～210	弱
44～ 84	211～295	中
85～138	296～367	强
≥139	≥368	很强

参数	分值
参数	0	1	2
肝炎起病进展至肝性脑病间隔时间(d)	≤5	6～10	≥11
PTA(%)	>20	>5～20	≤ 5
TBiL(mg/dL)	<10	10～<15	≥15
DBiL/TBiL	≥0.7	0.5～<0.7	<0.5
PLT(×10⁴/μL)	>10	>5～10	≤5
肝萎缩	无	有	－

参数	分值
参数	0	1	2
肝炎起病进展至肝性脑病间隔时间(d)	≤5	6～10	≥11
PTA(%)	>20	>5～20	≤ 5
TBiL(mg/dL)	<10	10～<15	≥15
DBiL/TBiL	≥0.7	0.5～<0.7	<0.5
PLT(×10⁴/μL)	>10	>5～10	≤5
肝萎缩	无	有	－

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