Current status and progress of research on prevention of tumor recurrence after liver transplantation for hepatocellular carcinoma

doi:10.3877/cma.j.issn.1674-3903.2023.03.009

Abstract

Abstract:

Liver transplantation is one of the most important tools for the radical treatment of hepatocellular carcinoma (HCC). As the incidence of HCC continues to rise worldwide, the number of patients awaiting transplantation with HCC as a primary indication is increasing. However, the recurrence after transplantation remains inevitable and is one of the leading causes of death after liver transplantation. Therefore, the key to improving the long-term outcome of liver transplantation for HCC is to prevent tumor recurrence after transplantation. This article reviews recent advances in HCC liver transplant recipient and donor selection, preoperative bridging and downstaging therapy, intraoperative tumor-free techniques and ischemia-reperfusion injury in transplantation, personalized immunosuppressive regimens, and postoperative adjuvant and antiviral therapy to provide a reference for research and clinical practice in the prevention of tumor recurrence after liver transplantation for HCC.

Key words: Hepatocellular carcinoma, Liver transplantation, Prevention, Recurrence

Qijian Yu, Zhe Yang, Shusen Zheng. Current status and progress of research on prevention of tumor recurrence after liver transplantation for hepatocellular carcinoma[J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(03): 171-179.

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