Research progress on xenotransplantation form pig organs

doi:10.3877/cma.j.issn.1674-3903.2023.03.011

Abstract

Abstract:

Because of the shortage of donor organs, numerous patients with acute or chronic organ failure died each year while waiting for transplantation. Although various extracorporeal support systems, such as artificial liver system and dialysis system, are widely used in clinical practice, they can only be used as transplant transition therapy and can not solve the fundamental problems of patients, and it is particularly important to expand the source of transplanted organs. Xenotransplantation has always been one of the key and difficult techniques unremittingly explored by the organ transplantation community, and transgenic pigs as one of the most promising organ donor sources for clinical xenotransplantation organs have received much attention. At present, a number of non-human primate experiments have confirmed the effectiveness of xenotransplantation, but there is still a lack of sufficient preclinical trials to verify its safety and effectiveness in humans. This article reviews the current status and problems faced by pig organ xenotransplantation in order to provide a new perspective on the treatment of end-stage organ failure.

Key words: Xenotransplantation, Genetic engineering, Pig, Immune rejection

Ziye Ai, Ling Li, Chongxiang He, Wei Huang, Qifa Ye. Research progress on xenotransplantation form pig organs[J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(03): 186-191.

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