Progress in research on the role and mechanism of gut microbiota in organ ischemia reperfusion injury

doi:10.3877/cma.j.issn.1674-3903.2024.04.009

Abstract

Abstract:

Ischemia reperfusion injury (IRI) refers to the damage caused when blood flow is restored to tissues or organs after a period of ischemia. In clinical practice, IRI is an inevitable occurrence during organ transplantation. The mechanisms underlying IRI are complex, and effective treatment options are still lacking. The intestinal flora plays a significant role in the development of multisystem diseases by regulating immune responses, inflammatory reactions, and the production of metabolic byproducts. It also exerts a profound impact on the IRI process in multiple organs. This article reviews recent progress in research on the roles and mechanisms of the intestinal flora and its metabolic products in IRI of the intestines, liver, kidneys, and other organs, with the hope of providing new diagnostic and therapeutic strategies for IRI.

Key words: Intestinal flora, Metabolites, Ischemia reperfusion injury

Xueling Wang, Huan Cao, Jinyang Gu. Progress in research on the role and mechanism of gut microbiota in organ ischemia reperfusion injury[J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(04): 247-250.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2024.04.009

https://zhyzzz.cma-cmc.com.cn/EN/Y2024/V18/I04/247

References 40

1	Carcy R, Cougnon M, Poet M, et al. Targeting oxidative stress, a crucial challenge in renal transplantation outcome[J]. Free Radic Biol Med, 2021,169:258-270.
2	Tang W, Backhed F, Landmesser U, et al. Intestinal microbiota in cardiovascular health and disease: JACC state-of-the-art review[J].J Am Coll Cardiol, 2019,73(16):2089-2105.
3	Castillo DJ, Rifkin RF, Cowan DA, et al. The healthy human blood microbiome: fact or fiction?[J]. Front Cell Infect Microbiol, 2019,9:148.
4	Deng F, Lin ZB, Sun QS, et al. The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury[J]. Int J Biol Sci, 2022,18(10):3981-3992.
5	Huang W, Yan Y, Wu M, et al. Preoperative fasting confers protection against intestinal ischaemia/reperfusion injury by modulating gut microbiota and their metabolites in a mouse model[J]. Br J Anaesth, 2022,128(3):501-512.
6	Hu J, Deng F, Zhao B, et al. Lactobacillus murinus alleviate intestinal ischemia/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via Toll-like receptor 2 signaling[J]. Microbiome, 2022,10(1):38.
7	Deng F, Hu JJ, Lin ZB, et al. Gut microbe-derived milnacipran enhances tolerance to gut ischemia/reperfusion injury[J]. Cell Rep Med, 2023,4(3):100979.
8	Deng F, Zhao BC, Yang X, et al. The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-inducedferroptosis [ J ].Gut Microbes, 2021,13(1):1-21.
9	Deng F, Hu JJ, Yang X, et al. Gut microbial metabolite pravastatin attenuates intestinal ischemia/reperfusion injury through promoting IL-13 release from type II innate lymphoid cells via IL-33/ST2 signaling[J]. Front Immunol, 2021,12:704836.
10	Zhang FL, Chen XW, Wang YF, et al. Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2[J]. J Transl Med, 2023,21(1):264.
11	Bosi A, Banfi D, Bistoletti M, et al. Hyaluronan regulates neuronal and immune function in the rat small intestine and colonic microbiota after ischemic/reperfusion injury[J]. Cells, 2022,11(21): 3370.
12	Vairetti M, Di Pasqua LG, Cagna M, et al. Changes in glutathione content in liver diseases: an update[J]. Antioxidants (Basel),2021,10(3): 364.
13	欧可, 彭秀达, 费书珂. 肝缺血再灌注损伤相关通路的研究进展[J]. 肝胆胰外科杂志, 2022, 34(9):571-576.
14	Cornide-Petronio ME, Alvarez-Mercado AI, Jimenez-Castro MB, et al. Current knowledge about the effect of nutritional status,supplemented nutrition diet, and gut microbiota on hepatic ischemiareperfusion and regeneration in liver surgery[J]. Nutrients, 2020,12(2):284.
15	Liu H, Wang J, Ding Y, et al. Antibiotic pretreatment attenuates liver ischemia-reperfusion injury by farnesoid X receptor activation[J]. Cell Death Dis, 2022,13(5):484.
16	Yang X, Lu D, Zhuo J, et al. The gut-liver axis in immune remodeling: new insight into liver diseases[J]. Int J Biol Sci, 2020,16(13):2357-2366.
17	Kawasoe J, Uchida Y, Kawamoto H, et al. Propionic acid, induced in gut by an inulin diet, suppresses inflammation and ameliorates liver ischemia and reperfusion injury in mice[J]. Front Immunol, 2022,13:862503.
18	Li R, Xie L, Li L, et al. The gut microbial metabolite, 3,4-dihydroxyphenylpropionicacid,alleviateshepaticischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice[J]. Acta Pharm Sin B, 2022,12(1):182-196.
19	He M, Wei W, Zhang Y, et al. Gut microbial metabolites SCFAs and chronic kidney disease[J]. J Transl Med, 2024,22(1):172.
20	Yang J, Kim CJ, Go YS, et al. Intestinal microbiota control acute kidney injury severity by immune modulation[J]. Kidney Int, 2020,98(4):932-946.
21	Zhang P, Han X, Zhang X, et al. Lactobacillus acidophilus ATCC 4356 alleviates renal ischemia-reperfusion injury through antioxidant stress and anti-inflammatory responses and improves intestinal microbial distribution[J]. Front Nutr, 2021,8:667695.
22	李娜. 短链脂肪酸通过抑制肾脏炎症减轻小鼠缺血再灌注肾损伤[D]. 太原:山西医科大学, 2023.
23	Stoeva MK, Garcia-So J, Justice N, et al. Butyrate-producing human gut symbiont, clostridium butyricum, and its role in health and disease[J]. Gut Microbes, 2021,13(1):1-28.
24	Heusch G. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective[J]. Nat Rev Cardiol, 2020,17(12):773-789.
25	Chen C, Zhang H, Xie R, et al. Gut microbiota aggravate cardiac ischemia-reperfusion injury via regulating the formation of neutrophils extracellular traps[J]. Life Sci, 2022, 303:120670.
26	Zhao J, Zhang Q, Cheng W, et al. Heart-gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia/reperfusion[J]. Cardiovasc Res, 2023, 119(6):1390-1402.
27	Bai H, Gu RJ, Chen LY, et al. Electroacupuncture interventions alleviates myocardial ischemia reperfusion injury through regulating gut microbiota in rats[J]. Microvasc Res, 2021,138:104235.
28	Liu Q, Zhu Y, Li G, et al. Irisin ameliorates myocardial ischemiareperfusion injury by modulating gut microbiota and intestinal permeability in rats[J]. PLoS One, 2023, 18(9):e0291022.
29	Zheng D, Liu Z, Zhou Y, et al. Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia/reperfusion injury via p62/Keap1/Nrf2 signaling pathway[J]. Pharmacol Res, 2020,153:104655.
30	Amani H, Mostafavi E, Alebouyeh MR, et al. Would colloidal gold nanocarriers present an effective diagnosis or treatment for ischemic stroke?[J]. Int J Nanomedicine, 2019,14:8013-8031.
31	Margolis KG, Cryan JF, Mayer EA. The Microbiota-gut-brain axis:from motility to mood[J]. Gastroenterology, 2021,160(5):1486-1501.
32	Feng Y, Zhang D, Zhao Y, et al. Effect of intestinal microbiota transplantation on cerebral ischemia reperfusion injury in aged mice via inhibition of IL-17[J]. Neurogastroenterol Motil, 2022,34(7):e14313.
33	Chen HD, Jiang MZ, Zhao YY, et al. Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-kappaB signaling pathway in rats[J]. J Ethnopharmacol, 2023, 300:115691.
34	Xian M, Shen L, Zhan S, et al. Integrated 16S rRNA gene sequencing and LC/MS-based metabolomics ascertained synergistic influences of the combination of acupuncture and NaoMaiTong on ischemic stroke[J]. J Ethnopharmacol, 2022, 293:115281.
35	王凯. 黄芪红花配伍调控肠道菌群影响胆汁酸代谢发挥脑保护作用的机制研究[D]. 咸阳:陕西中医药大学, 2021.
36	Wang YH, Yan ZZ, Luo SD, et al. Gut microbiota-derived succinate aggravates acute lung injury after intestinal ischaemia/reperfusion in mice[J]. Eur Respir J, 2023,61(2): 2200840.
37	Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome[J]. J Clin Invest, 2012, 122(8):2731-2740.
38	Dang AT, Marsland BJ. Microbes, metabolites, and the gut-lung axis[J]. Mucosal Immunol, 2019, 12(4):843-850.
39	Hung KY, Wu SY, Pao HP, et al. Acetate, a gut bacterial product,ameliorates ischemia-reperfusion induced acute lung injury in rats[J]. Int Immunopharmacol, 2022, 111:109136.
40	尹国芳. 粪菌移植对脂多糖诱导的大鼠急性肺损伤的影响及调控机制[D]. 泸州:西南医科大学, 2019.

[1]	Jiaxing Li, Yiwen Sun, Wenxing Li. Advances in the role of NLRP3 inflammasome in acute pancreatitis [J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(04): 300-304.
[2]	Xiuyang Zhang, Longfei Zhang, Shiyuan Chen, Yong Gao. Hypoxia-inducible factor-1α mediating the expression of monocarboxylate transporter-1 and participating in the protective effect of short-chain fatty acids on intestinal hypoxia [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(01): 18-23.
[3]	Ling Li, Ya Liu, Peiling Li, Xiumin Zhang, Ping Li. Study on the relationship between postoperative intestinal flora and depression in patients with rectal cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(06): 607-610.
[4]	Cong Peng, Xiaoying Luo, Yangqiu Bai, Xiaoke Jiang, Bingyong Zhang. Research progress in the interaction between intestinal flora metabolites and mesenchymal stem cells [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(06): 367-371.
[5]	Jixin He, Yanni Yang, Jiwei Wang, Jianguo Li, Ming Xie. Research progress on the mechanism of intestinal flora metabolites involved in the occurrence of chronic constipation [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(06): 495-499.
[6]	Xiaomin Zhao, Jun Yang, Weiwei Tian. Efficacy of Zhizhu grain combined with Linaclotide in the treatment of irritable bowel syndrome with predominant constipation [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(05): 465-469.
[7]	Ling Qiu, Xuli Zhu, Jian Pu, Miaomiao Xing, Jialing Wu. Correlation between ecological characteristics of intestinal flora and gastrointestinal dysfunction in patients with diabetic nephropathy [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(05): 453-458.
[8]	Hong Xie, Na Li, Shangri Li, Tao Xie. Effect of intestinal flora characteristics on the therapeutic effect of different chemotherapy regimens for colorectal cancer [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(01): 53-56.
[9]	Han Sun, Xia Wu. Correlations between gut microbiota characteristics and quality of life and psychiatric symptoms in adult irritable bowel syndrome patients with different subtypes [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 461-465.
[10]	Xiang Liao, Shuang Li, Yao Zeng. Analysis of research trends and hotspots of fecal microbiota transplantation from 2012 to 2021 [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(02): 93-99.
[11]	Jiachao Han, Feifei Wang, Zining Liu, Jitao Hu, Zesong Meng, Yueyun Luo, Guiying Wang. Progress in reearch of action of mechanism of metformin [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(03): 349-355.
[12]	Yan Liu, Shenjie Tang. Research progress on the correlation of intestinal flora with antitubercular agents and antitubercular agents-induced liver injury [J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 82-86.
[13]	Ning Li, Yan Liu, Huiqing Lin. Mechanism and prevention of ischemia-reperfusion injury of donor lung transplantation [J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2023, 10(04): 247-256.
[14]	Kangwei Liu, Jianfeng Yao. Advances in research on gut microbiota in elderly patients with chronic constipation [J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2023, 10(04): 40-46.
[15]	Yisireyili Maimaiti·, Yongkang Wang, Wusiman Ababokeli, Abudureyimu Kelimu·. Analysis of structural characteristics of intestinal flora in high-fat diet inducedobesity mice based on 16s rRNA sequencing [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2023, 09(01): 12-16.

Please choose a citation manager

Content to export