Chinese expert consensus on organ transportation

doi:10.3877/cma.j.issn.1674-3903.2025.03.003

Abstract

Abstract:

The development of donation after citizen′s death and transplantation in China has progressed rapidly, with long-distance and prolonged organ transportation becoming a routine practice. Efficient, safe organ transportation and data management are critical to ensuring standardized transplant operations. In accordance with the Regulations on Human Organ Donation and Transplantation and to maximize the efficacy of the National Organ Transportation Green Channel initiative, standardize and enhance the quality of organ transportation at transplant centers, provincial levels, and nationwide, a group of leading experts has developed the Chinese Expert Consensus on Organ Transportation. By establishing standardized transport protocols, technical benchmarks, and digital management platforms, this consensus aims to further improve the efficiency and standardization of organ transfer operations, promoting high-quality development in China′s organ donation and transplantation.

Key words: Organ transplantation, Organ protection, Organ Transportation, Expert consensus

China Liver Transplant Registry, National Center for Healthcare Quality Management in Liver Transplant, National Quality Control Center for Donated Organ Procurement, National Clinical Research Center for Orthopedics, Sports Medicine Rehabilitation, Committee on Transplant Organ Quality Control, Branch of Organ Transplant Doctor, Chinese Medical Doctor Association, Organ Procurement and Allocation Working Committee of the China Hospital Association, National Trauma Medical Center Organ Protection Committee. Chinese expert consensus on organ transportation[J]. Chinese Journal of Transplantation(Electronic Edition), 2025, 19(03): 131-137.

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References 49

1	国家卫生健康委员会．2022年国家医疗服务与质量安全报告[M]. 北京：科学技术文献出版社，2023.
2	Anderson DJ, Locke JE. Progress towards solving the donor organ shortage[J]. Nat Rev Nephrol, 2023, 19(2)：83-84.
3	Sykes M, Sachs DH. Progress in xenotransplantation: overcoming immune barriers[J]. Nat Rev Nephrol, 2022, 18(12)：745-761.
4	Matas AJ, Montgomery RA, Schold JD. The organ shortage continues to be a crisis for patients with end-stage kidney disease[J]. JAMA Surg, 2023, 158(8)：787-788.
5	国家卫生和计划生育委员会，公安部，交通运输部，等．关于建立人体捐献器官转运绿色通道的通知[EB/OL]. (2016-05-06) [2025-06-10]. URL
6	中华人民共和国国务院．人体器官捐献和移植条例[EB/OL].(2023-12-14)[2025-06-10]. URL
7	Zhang Q, Tong J, Zhou W, et al. Antibacterial and antioxidant chitosan nanoparticles improve the preservation effect for donor kidneys in vitro[J]. Carbohydr Polym, 2022, 287：119326.
8	Zhou W, Zhong Z, Lin D. Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury[J]. Cell Death Dis, 2021, 12(2)：211.
9	Liang H, Zhang P, Yu B, et al. Machine perfusion combined with antibiotics prevents donor-derived infections caused by multidrug-resistant bacteria[J]. Am J Transplant, 2022, 22(7)：1791-1803.
10	Luo J, Hu Y, Qiao Y, et al. Hypothermic oxygenated machine perfusion promotes mitophagy flux against hypoxia-ischemic injury in rat DCD liver[J]. Int J Mol Sci, 2023, 24(6)：5403.
11	Qiao Y, Li J, Bian S, et al. Application of biocompatible custom ceria nanoparticles in improving the quality of liver grafts for transplantation[J]. Nano Research, 2023, 16(4)：5176-5188.
12	国家卫生健康委、国家中医药局、国家疾控局. "十四五"全民健康信息化规划[EB/OL].(2022-11-09)[2025-06-10]. URL
13	宋伟，刘谋友，杨余富，等. 北斗卫星导航系统在卫勤保障中的应用探讨[J]. 医疗装备，2012, 25(2): 17-19.
14	张秋军，孙婕，王泽阳，等. 基于移动物联网的健康管理平台在医疗设备智能化管理中的应用[J]. 中国医疗设备，2025, 40(8): 58-63.
15	Centers for Medicare and Medicaid Services. State operations manual appendix Y[a1][2]-organ procurement organization (OPO) interpretive guidance[EB/OL]. (2018-01-05) [2025-06-10]. URL
16	Transplantation Society of Australia and New Zealand. National Standard Operation Procedures - Packaging, Labelling, Storage & Documentation of deceased donor vessels [EB/OL]. (2020-04-01) [2025-06-10]. URL
17	De Beule J, Fieuws S, Monbaliu D, et al. The effect of IGL-1 preservation solution on outcome after kidney transplantation: a retrospective single-center analysis[J]. Am J Transplant, 2021, 21(2)：830-837.
18	Panayotova GG, Lunsford KE, Quillin RC, et al. Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: a randomized, open-label, clinical trial[J]. Hepatology, 2024, 79(5)：1033-1047.
19	van Rijn R, Schurink IJ, de Vries Y, et al. Hypothermic machine perfusion in liver transplantation-a randomized trial[J]. N Engl J Med, 2021, 384(15)：1391-1401.
20	Malinoski D, Saunders C, Swain S, et al. Hypothermia or machine perfusion in kidney donors[J]. N Engl J Med, 2023, 388(5)：418-426.
21	Schlegel A, Mergental H, Fondevila C, et al. Machine perfusion of the liver and bioengineering[J]. J Hepatol, 2023, 78(6)：1181-1198.
22	Schlegel A, Porte R, Dutkowski P. Protective mechanisms and current clinical evidence of hypothermic oxygenated machine perfusion (HOPE) in preventing post-transplant cholangiopathy[J]. J Hepatol, 2022, 76(6)：1330-1347.
23	Kang XY, Cheng JY, Ge WY, et al. Revolution in organ preservation: technological exploration[J]. Acta Biomater, 2025, 199：50-73.
24	中国肝移植注册中心，国家肝脏移植质控中心，国家人体捐献器官获取质控中心，等. 中国移植器官保护专家共识(2022版)[J/OL]. 中华移植杂志：电子版，2022, 16(1)：1-12.
25	Niroomand A, Lindstedt S. Current challenges in lung transplantation[J]. J Intern Med, 2025, 297(4)：355-365.
26	中华医学会器官移植学分会，中国医师协会器官移植医师分会. 遗体捐献器官获取工作指南[J/OL]. 中国医学前沿杂志：电子版，2024，16(11)：1-16.
27	Hosgood SA, Callaghan CJ, Wilson CH, et al. Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial[J]. Nat Med, 2023, 29(6)：1511-1519.
28	Lascaris B, de Meijer VE, Porte RJ. Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store for us？[J]. J Hepatol, 2022, 77(3)：825-836.
29	Markmann JF, Abouljoud MS, Ghobrial RM. Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS liver protect randomized clinical trial[J]. JAMA Surg, 2022, 157(3)：189-198.
30	Hann A, Lembach H, Nutu A, et al. Outcomes of normothermic machine perfusion of liver grafts in repeat liver transplantation (NAPLES initiative) [J]. Br J Surg, 2022, 109(4)：372-380.
31	OPTN. Organ Procurement and Transplantation Network (OPTN) Policies[EB/OL]. (2020-06-18)[2025-06-10]. URL
32	Roza BA, Paim SMS, Leite R, et al. Safe transport of organs and tissues for transplants: technological innovation product validation method[J]. Rev Assoc Med Bras (1992), 2023, 69(6): e20221537.
33	Schlegel A, Mueller M, Muller X, et al. A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation[J]. J Hepatol, 2023，78(4)：783-793.
34	Husen P, Boffa C, Jochmans I, et al. Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant: a randomized clinical trial[J]. JAMA Surg, 2021, 156(6)：517-525.
35	Mergental H, Laing RW, Kirkham AJ, et al. Transplantation of discarded livers following viability testing with normothermic machine perfusion[J]. Nat Commun, 2020, 11(1)：2939.
36	Meszaros AT, Hofmann J, Buch ML, et al. Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome[J]. EBioMedicine, 202, 85：104311.
37	Grᶏt M, Morawski M, Zhylko A, et al. Routine end-ischemic hypothermic oxygenated machine perfusion in liver transplantation from donors after brain death: a randomized controlled trial[J]. Ann Surg, 2023, 278(5)：662-668.
38	Karangwa S, Panayotova G, Dutkowski P, et al. Hypothermic machine perfusion in liver transplantation[J]. Int J Surg, 2020, 82S：44-51.
39	Knijff LWD, van Kooten C, Ploeg RJ. The effect of hypothermic machine perfusion to ameliorate ischemia-reperfusion injury in donor organs[J]. Front Immunol, 2022, 13：848352.
30	Puttarajappa CM, Jorgensen D, Yabes JG, et al. Trends and impact on cold ischemia time and clinical outcomes using virtual crossmatch for deceased donor kidney transplantation in the United States[J]. Kidney Int, 2021, 100(3)：660-671.
41	Placona AM, Humphries C, Curran C, et al. Association of transit time with cold ischemic time in kidney transplantation[J]. JAMA Netw Open, 2021, 4(12)：e2141108.
42	Gorbacheva V, Fan R, Beavers A, et al. Anti-donor MHC class Ⅱalloantibody induces glomerular injury in mouse renal allografts subjected to prolonged cold ischemia[J]. J Am Soc Nephrol, 2019，30(12)：2413-2425.
43	中华医学会器官移植学分会，中国医师协会器官移植医师分会，中国医疗保健国际交流促进会肾脏移植学分会. 中国遗体器官捐献供肾体外低温机械灌注保存指南[J]. 器官移植，2024, 15(6)：837-845.
44	黄启恒，汪国营. 供肝的质量评估与保存策略[J]. 器官移植，2025, 16(4)：609-619.
45	胡春晓，邵景博，赵晋，等. 移植供肺的保存与功能维护[J]. 器官移植，2023, 14(2)：213-219.
46	郑树森. 中国器官移植发展方向——注重质量、严格规范、谋求精准、融汇大数据[J]. 手术，2016, 1(1)：1-2, 7.
47	石炳毅，刘志佳. 构建质量提升计划系统，促进器官移植转型发展[J]. 器官移植，2020，11(1): 1-7.
48	赵辉，杨扬，徐骁. 肝脏移植标准数据集[J]. 器官移植，2020，11(1)：126-175.
49	国家卫生健康委办公厅，国家中医药局综合司，国家疾控局综合司. 关于进一步加强医疗机构电子病历信息使用管理的通知[EB/OL].(2025-06-23)[2025-06-24]. URL

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