Pancreatic allograft resection serves as a critical surgical intervention for severe complications arising from pancreatic allograft dysfunction, directly influencing recipient outcomes. Currently, no expert consensus or guidelines are available domestically and internationally to standardize its clinical application. This consensus systematically delineates the indications, timing, key technical aspects, perioperative management, and psychological assessment and intervention strategies for pancreatic allograft resection. Indications are classified by time of onset into early (thrombosis, transplant pancreatitis), intermediate (intra-abdominal infection, invasive vasculitis), and late stage (rejection, vascular complications, and de novo tumor), with a clear recommendation for conservative management in asymptomatic allograft dysfunction. Surgical techniques should be tailored to the original transplant procedure (including systemic/portal venous drainage and enteric/bladder drainage methods), focusing on vascular control, thrombosis management, and reconstruction of digestive/urinary anastomoses. Postoperative management involves management of complications, blood glucose regulation, adjustment of immunosuppressive regimens, and systematic psychosocial interventions, underscored by multidisciplinary collaboration to optimize patient outcomes. This consensus aims to establish a standardized reference for clinical practice, ultimately improving long-term quality of life for recipients.