Distribution characteristics of lung pathogens and strategies of prophylactic antibiotics in lung transplant donors and recipients during operation and 48 hours after operation

doi:10.3877/cma.j.issn.1674-3903.2021.05.005

Abstract

Key words: Lung transplantation, Infection, Drug resistance

Sichao Gu, Min Li, Run Tong, Qingyuan Zhan. Distribution characteristics of lung pathogens and strategies of prophylactic antibiotics in lung transplant donors and recipients during operation and 48 hours after operation[J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 282-285.

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References 16

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菌种		菌株数(株)	构成比(%)
革兰阴性菌		93	61.2
	铜绿假单孢菌	27	17.8
	肺炎克雷伯菌	20	13.2
	鲍曼不动杆菌	14	9.2
	嗜麦芽窄食单孢菌	8	5.3
	多食伯克霍德尔菌	4	2.6
	阴沟肠杆菌	3	2.0
	大肠埃希菌	2	1.3
	皮氏不动杆菌	2	1.3
	产吲哚金黄杆菌	1	0.7
	产酸克雷伯菌	1	0.7
	产气肠杆菌	1	0.7
	弗氏柠檬酸杆菌	1	0.7
	温哥华假单孢菌	1	0.7
	施氏假单孢菌	1	0.7
	黏质沙雷菌	1	0.7
	牙枝状枝孢菌	1	0.7
	琼氏不动杆菌	1	0.7
	奇异变形杆菌	1	0.7
	木糖氧化无色杆菌	1	0.7
	假单孢菌	1	0.7
	解鸟氨酸拉乌尔菌	1	0.7
革兰阳性菌		31	20.4
	金黄色葡蔔球菌	12	7.9
	屎肠球菌	6	3.9
	纹带棒状杆菌	5	3.3
	粪肠球菌	3	2.0
	溶血葡萄球菌	2	1.3
	人葡萄球菌	1	0.7
	表皮葡萄球菌	1	0.7
	巴氏葡萄球菌	1	0.7
假丝酵母菌属		18	11.8
	白假丝酵母菌	6	3.9
	近平滑假丝酵母菌	4	2.6
	光滑假丝酵母菌	4	2.6
	热带假丝酵母菌	2	1.3
	克柔假丝酵母菌	2	1.3
曲霉		10	6.6
	烟曲霉	3	2.0
	杂色曲霉	2	1.3
	黑曲霉	2	1.3
	土曲霉	1	0.7
	构巢曲霉	1	0.7
	未分类	1	0.7

菌种		菌株数(株)	构成比(%)
革兰阴性菌		93	61.2
	铜绿假单孢菌	27	17.8
	肺炎克雷伯菌	20	13.2
	鲍曼不动杆菌	14	9.2
	嗜麦芽窄食单孢菌	8	5.3
	多食伯克霍德尔菌	4	2.6
	阴沟肠杆菌	3	2.0
	大肠埃希菌	2	1.3
	皮氏不动杆菌	2	1.3
	产吲哚金黄杆菌	1	0.7
	产酸克雷伯菌	1	0.7
	产气肠杆菌	1	0.7
	弗氏柠檬酸杆菌	1	0.7
	温哥华假单孢菌	1	0.7
	施氏假单孢菌	1	0.7
	黏质沙雷菌	1	0.7
	牙枝状枝孢菌	1	0.7
	琼氏不动杆菌	1	0.7
	奇异变形杆菌	1	0.7
	木糖氧化无色杆菌	1	0.7
	假单孢菌	1	0.7
	解鸟氨酸拉乌尔菌	1	0.7
革兰阳性菌		31	20.4
	金黄色葡蔔球菌	12	7.9
	屎肠球菌	6	3.9
	纹带棒状杆菌	5	3.3
	粪肠球菌	3	2.0
	溶血葡萄球菌	2	1.3
	人葡萄球菌	1	0.7
	表皮葡萄球菌	1	0.7
	巴氏葡萄球菌	1	0.7
假丝酵母菌属		18	11.8
	白假丝酵母菌	6	3.9
	近平滑假丝酵母菌	4	2.6
	光滑假丝酵母菌	4	2.6
	热带假丝酵母菌	2	1.3
	克柔假丝酵母菌	2	1.3
曲霉		10	6.6
	烟曲霉	3	2.0
	杂色曲霉	2	1.3
	黑曲霉	2	1.3
	土曲霉	1	0.7
	构巢曲霉	1	0.7
	未分类	1	0.7

抗菌药物	铜绿假单孢菌(n＝27)		肺炎克雷伯菌(n＝20)		鲍曼不动杆菌(n＝14)		其他(n＝32)
抗菌药物	检测(株)	耐药率(%)	检测(株)	耐药率(%)	检测(株)	耐药率(%)	检测(株)	耐药率(%)
阿米卡星	27	14.8	19	42.1	14	78.6	18	16.7
头孢哌酮/舒巴坦	27	29.6	20	40.0	14	57.1	19	26.3
米诺环素	-	-	20	10.0	14	35.7	22	9.1
替加环素	-	-	20	0	14	0	13	7.7
哌拉西林	21	33.3	20	75.0	10	80.0	16	43.8
氨苄西林	-	-	-	-	-	-	6	83.3
氨苄西林/舒巴坦	-	-	19	73.7	11	81.8	7	42.9
哌拉西林/舒巴坦	27	25.9	20	45.0	13	84.6	17	23.5
头孢呋辛	-	-	19	73.7	1	100.0	5	20.0
头孢呋辛酯	-	-	19	73.7	1	100.0	5	20.0
头孢曲松	-	-	20	75.0	10	90.0	15	33.3
头孢他啶	26	23.1	20	65.0	14	92.9	20	25.0
头孢吡肟	26	19.2	20	55.0	14	71.4	14	7.1
头孢替坦	1	0	20	40.0	1	100.0	6	33.3
头孢唑啉	1	0	20	75.0	1	100.0	5	40.0
氨曲南	26	38.5	20	75.0	-	-	15	40.0
亚胺培南	27	37.0	20	40.0	14	92.9	18	27.8
美罗培南	27	37.0	20	40.0	14	92.9	20	20.0
环丙沙星	27	11.1	20	65.0	14	92.9	19	42.1
左氧氟沙星	27	18.5	20	65.0	14	71.4	28	25.0
庆大霉素	21	23.8	20	60.0	10	80.0	16	37.5
妥布霉素	27	14.8	20	50.0	14	85.7	19	15.8
复方磺胺甲噁唑	1	100.0	20	25.0	14	71.4	27	22.2
多西菌素	-	-	-	-	4	75.0	2	0
黏菌素	4	0	-	-	4	25.0	3	33.3
替卡西林/棒酸	6	33.3	-	-	3	100.0	3	66.7

抗菌药物	铜绿假单孢菌(n＝27)		肺炎克雷伯菌(n＝20)		鲍曼不动杆菌(n＝14)		其他(n＝32)
抗菌药物	检测(株)	耐药率(%)	检测(株)	耐药率(%)	检测(株)	耐药率(%)	检测(株)	耐药率(%)
阿米卡星	27	14.8	19	42.1	14	78.6	18	16.7
头孢哌酮/舒巴坦	27	29.6	20	40.0	14	57.1	19	26.3
米诺环素	-	-	20	10.0	14	35.7	22	9.1
替加环素	-	-	20	0	14	0	13	7.7
哌拉西林	21	33.3	20	75.0	10	80.0	16	43.8
氨苄西林	-	-	-	-	-	-	6	83.3
氨苄西林/舒巴坦	-	-	19	73.7	11	81.8	7	42.9
哌拉西林/舒巴坦	27	25.9	20	45.0	13	84.6	17	23.5
头孢呋辛	-	-	19	73.7	1	100.0	5	20.0
头孢呋辛酯	-	-	19	73.7	1	100.0	5	20.0
头孢曲松	-	-	20	75.0	10	90.0	15	33.3
头孢他啶	26	23.1	20	65.0	14	92.9	20	25.0
头孢吡肟	26	19.2	20	55.0	14	71.4	14	7.1
头孢替坦	1	0	20	40.0	1	100.0	6	33.3
头孢唑啉	1	0	20	75.0	1	100.0	5	40.0
氨曲南	26	38.5	20	75.0	-	-	15	40.0
亚胺培南	27	37.0	20	40.0	14	92.9	18	27.8
美罗培南	27	37.0	20	40.0	14	92.9	20	20.0
环丙沙星	27	11.1	20	65.0	14	92.9	19	42.1
左氧氟沙星	27	18.5	20	65.0	14	71.4	28	25.0
庆大霉素	21	23.8	20	60.0	10	80.0	16	37.5
妥布霉素	27	14.8	20	50.0	14	85.7	19	15.8
复方磺胺甲噁唑	1	100.0	20	25.0	14	71.4	27	22.2
多西菌素	-	-	-	-	4	75.0	2	0
黏菌素	4	0	-	-	4	25.0	3	33.3
替卡西林/棒酸	6	33.3	-	-	3	100.0	3	66.7

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