The progress of extracellular vesicle in diagnosis and treatment of kidney transplantation

doi:10.3877/cma.j.issn.1674-3903.2024.03.008

Abstract

Abstract:

Extracellular vesicle (EV) is a lipid-bilayer particle released by cells into the extracellular environment with a range of signaling roles involved in a variety of physiological and pathological processes. Recently, increasing studies have found that EV has great potential as disease biomarker and therapeutic carrier. In the field of renal transplantation, researches have shown that urinary EV could reflect the pathophysiological status of the allograft and has been considered as a potential non-invasive diagnostic and prognostic biomarker. In addition, EV derived from certain cells has therapeutic properties of immunomodulation in transplantation and is proposed as an upcoming drug delivery platform with advantages of low immunogenicity, high tissue targeting and engineering potential. Therefore, this review described the classification, isolation and characterization of EV and introduced the research progress of EV in diagnosis and treatment of renal transplantation.

Key words: Extracellular vesicle, Kidney transplantation, Biomarker, Therapeutics

Junhao Lyu, Jinwen Lin, Xinyi Zhang, Jianghua Chen. The progress of extracellular vesicle in diagnosis and treatment of kidney transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(03): 186-192.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2024.03.008

https://zhyzzz.cma-cmc.com.cn/EN/Y2024/V18/I03/186

References 63

1	Zhao J, Zhu W, Mao Y, et al. Unignored intracellular journey and biomedical applications of extracellular vesicles[J]. Adv Drug Deliv Rev, 2024: 115388.
2	Ko SY, Lee W, Naora H. Harnessing microRNA-enriched extracellular vesicles for liquid biopsy[J]. Front Mol Biosci, 2024, 11: 1356780.
3	王玺惠，陈依，俞卫锋. 凋亡胞外囊泡在炎症与肿瘤发生、发展中的作用研究进展[J]. 浙江医学，2023，45(10): 1116-1120.
4	史婷婷，张润兵，伍杨，等. 不同来源的细胞外囊泡在肝细胞癌发生进展中的作用[J]. 临床肝胆病杂志，2024，40(6): 1264-1268.
5	Gołębiewska JE, Wardowska A, Pietrowska M, et al. Small extracellular vesicles in transplant rejection [J]. Cells, 2021, 10(11): 10112989
6	Zeng F, Chen Z, Chen R, et al. Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation[J]. Sci Transl Med, 2021, 13(585): eabb0122.
7	Ashcroft J, Leighton P, Elliott TR, et al. Extracellular vesicles in kidney transplantation: a state-of-the-art review [J]. Kidney Int, 2022, 101(3): 485-497.
8	Welsh JA, Goberdhan DCI, O′driscoll L, et al. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches [J]. J Extracell Vesicles, 2024, 13(2): e12404.
9	Kalluri R, Lebleu VS. The biology, function, and biomedical applications of exosomes[J]. Science, 2020, 367(6478): eaau6977.
10	Caruso S, Poon IKH. Apoptotic cell-derived extracellular vesicles: more than just debris[J]. Front Immunol, 2018, 9：1486.
11	Gardiner C, Di Vizio D, Sahoo S, et al. Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey[J]. J Extracell Vesicles, 2016, 5：32945.
12	Monguio-Tortajada M, Galvez-Monton C, Bayes-Genis A, et al. Extracellular vesicle isolation methods: rising impact of size-exclusion chromatography[J]. Cell Mol Life Sci, 2019, 76(12): 2369-2382.
13	Sidhom K, Obi PO, Saleem A. A review of exosomal isolation methods: is size exclusion chromatography the best option？[J]. Int J Mol Sci, 2020, 21(18): 21186466.
14	Koiffman N, Biran I, Aharon A, et al. A direct-imaging cryo-EM study of shedding extracellular vesicles from leukemic monocytes [J]. J Struct Biol, 2017, 198(3): 177-185.
15	Thery C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines[J]. J Extracell Vesicles, 2018, 7(1): 1535750.
16	Cuadrado-Payan E, Ramirez-Bajo MJ, Banon-Maneus E, et al. Physiopathological role of extracellular vesicles in alloimmunity and kidney transplantation and their use as biomarkers[J]. Front Immunol, 2023, 14：1154650.
17	Abinti M, Favi E, Alfieri CM, et al. Update on current and potential application of extracellular vesicles in kidney transplantation[J]. Am J Transplant, 2023, 23(11): 1673-1693.
18	Turco AE, Lam W, Rule AD, et al. Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys[J]. J Extracell Vesicles, 2016, 5：29642.
19	Oshikawa-Hori S, Yokota-Ikeda N, Sonoda H, et al. Reduced urinary release of AQP1- and AQP2-bearing extracellular vesicles in patients with advanced chronic kidney disease[J]. Physiol Rep, 2021, 9(17): e15005.
20	Ines Lozano-Ramos S, Bancu I, Carreras-Planella L, et al. Molecular profile of urine extracellular vesicles from normo-functional kidneys reveal minimal differences between living and deceased donors [J]. BMC Nephrol, 2018, 19(1)：189.
21	Gremmels H, De Jong OG, Toorop RJ, et al. The small RNA repertoire of small extracellular vesicles isolated from donor kidney preservation fluid provides a source for biomarker discovery for organ quality and posttransplantation graft function[J]. Transplant Direct, 2019, 5(9): e484.
22	Alvarez S, Suazo C, Boltansky A, et al. Urinary exosomes as a source of kidney dysfunction biomarker in renal transplantation[J]. Transplant Proc, 2013, 45(10): 3719-3723.
23	Dimuccio V, Ranghino A, Barbato LP, et al. Urinary CD133^＋ extracellular vesicles are decreased in kidney transplanted patients with slow graft function and vascular damage[J]. PLoS One, 2014, 9(8)：e104490.
24	Asvapromtada S, Sonoda H, Kinouchi M, et al. Characterization of urinary exosomal release of aquaporin-1 and-2 after renal ischemia-reperfusion in rats[J]. Am J Physiol Renal Physiol, 2018, 314(4): F584-F601.
25	Wang J, Li X, Wu X, et al. Expression profiling of exosomal miRNAs derived from the peripheral blood of kidney recipients with DGF using high-throughput sequencing[J]. Biomed Res Int, 2019, 2019: 1759697.
26	Al-Nedawi K, Haas-Neill S, Gangji A, et al. Circulating microvesicle protein is associated with renal transplant outcome[J]. Transpl Immunol, 2019, 55: 101210.
27	Rutman AK, Negi S, Saberi N, et al. Extracellular vesicles from kidney allografts express miR-218-5p and alter Th17/Treg ratios[J]. Front Immunol, 2022, 13：784374.
28	Park J, Lin HY, Assaker JP, et al. Integrated kidney exosome analysis for the detection of kidney transplant rejection[J]. Acs Nano, 2017, 11(11): 11041-11046.
29	Takada Y, Kamimura D, Jiang JJ, et al. Increased urinary exosomal SYT17 levels in chronic active antibody-mediated rejection after kidney transplantation via the IL-6 amplifier[J]. Int Immunol, 2020, 32(10): 653-662.
30	El Fekih R, Hurley J, Tadigotla V, et al. Discovery and validation of a urinary exosome mRNA signature for the diagnosis of human kidney transplant rejection[J]. J Am Soc Nephrol, 2021, 32(4): 994-1004.
31	Lim JH, Lee CH, Kim KY, et al. Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: A cross-sectional study[J]. PloS One, 2018, 13(9): e0204204.
32	Sigdel TK, Ng YW, Lee S, et al. Perturbations in the urinary exosome in transplant rejection[J]. Front Med (Lausanne), 2014, 1：57.
33	Tower CM, Reyes M, Nelson K, et al. Plasma C4d^＋ endothelial microvesicles increase in acute antibody-mediated rejection[J]. Transplantation, 2017, 101(9): 2235-2243.
34	Zhang H, Huang E, Kahwaji J, et al. Plasma exosomes from HLA-sensitized kidney transplant recipients contain mRNA transcripts which predict development of antibody-mediated rejection[J]. Transplantation, 2017, 101(10): 2419-2428.
35	Sharma M, Ravichandran R, Bansal S, et al. Tissue-associated self-antigens containing exosomes: role in allograft rejection[J]. Hum Immunol, 2018, 79(9): 653-658.
36	Saejong S, Townamchai N, Somparn P, et al. MicroRNA-21 in plasma exosome, but not from whole plasma, as a biomarker for the severe interstitial fibrosis and tubular atrophy (IF/TA) in post-renal transplantation[J]. Asian Pac J Allergy Immunol, 2022, 40(1): 94-102.
37	Chen Y, Han X, Sun Y, et al. A circulating exosomal microRNA panel as a novel biomarker for monitoring post-transplant renal graft function[J]. J Cell Mol Med, 2020, 24(20): 12154-12163.
38	Carreras-Planella L, Cucchiari D, Canas L, et al. Urinary vitronectin identifies patients with high levels of fibrosis in kidney grafts[J]. J Nephrol, 2021, 34(3): 861-874.
39	雷嘉豪，缪炳文，缪辉来. 细胞外囊泡与非编码RNA在肝缺血再灌注损伤中作用的研究进展[J]. 肝胆胰外科杂志，2023，35(7)：439-443.
40	Lazana I, Vassilopoulos G. A 'waste product' to save the day in the field of transplantation: the evolving potential of extracellular vesicles[J]. Immunology, 2022, 167(2): 154-164.
41	Lindoso RS, Collino F, Bruno S, et al. Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury[J]. Stem Cells Dev, 2014, 23(15): 1809-1819.
42	Zou XY, Zhang GY, Cheng ZL, et al. Microvesicles derived from human Wharton′s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1[J]. Stem Cell Res Ther, 2014, 5(2): 40.
43	Vinas JL, Burger D, Zimpelmann J, et al. Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury[J]. Kidney Int, 2016, 90(6): 1238-1250.
44	Pang P, Abbott M, Chang SL, et al. Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks[J]. Kidney Int, 2017, 91(1): 129-143.
45	Dominguez JH, Liu Y, Gao H, et al. Renal tubular cell-derived extracellular vesicles accelerate the recovery of established renal ischemia reperfusion injury[J]. J Am Soc Nephrol, 2017, 28(12): 3533-3544.
46	Pan W, Li S, Li K, et al. Mesenchymal stem cells and extracellular vesicles: therapeutic potential in organ transplantation[J]. Stem Cells Int, 2024, 2024：2043550.
47	Gregorini M, Corradetti V, Pattonieri EF, et al. Perfusion of isolated rat kidney with mesenchymal stromal cells/extracellular vesicles prevents ischaemic injury[J]. J Cell Mol Med, 2017, 21(12): 3381-3393.
48	Grignano MA, Bruno S, Viglio S, et al. CD73-adenosinergic axis mediates the protective effect of extracellular vesicles derived from mesenchymal stromal cells on ischemic renal damage in a rat model of donation after circulatory death[J]. Int J Mol Sci, 2022, 23(18): 10681.
49	Rampino T, Gregorini M, Germinario G, et al. Extracellular vesicles derived from mesenchymal stromal cells delivered during hypothermic oxygenated machine perfusion repair ischemic/reperfusion damage of kidneys from extended criteria donors[J]. Biology, 2022, 11(3): 350.
50	Burrello J, Monticone S, Gai C, et al. Stem cell-derived extracellular vesicles and immune-modulation [J]. Front Cell Dev Biol, 2016, 4: 83.
51	Koch M, Lemke A, Lange C. Extracellular Vesicles from MSC modulate the immune response to renal allografts in a MHC disparate rat model [J]. Stem Cells Int, 2015, 2015: 486141.
52	Wu XQ, Yan TZ, Wang ZW, et al. BM-MSCs-derived microvesicles promote allogeneic kidney graft survival through enhancing micro-146a expression of dendritic cells[J]. Immunol Lett, 2017, 191：55-62.
53	Jose Ramirez-Bajo M, Rovira J, Lazo-Rodriguez M, et al. Impact of mesenchymal stromal cells and their extracellular vesicles in a rat model of kidney rejection[J]. Front Cell Dev Biol, 2020, 8: 10.
54	Fang Y, Bouari S, Hoogduijn MJ, et al. Therapeutic efficacy of extracellular vesicles to suppress allograft rejection in preclinical kidney transplantation models: a systematic review and meta-analysis[J]. Transplant Rev (Orlando), 2022, 36(4): 100714.
55	Peche H, Renaudin K, Beriou G, et al. Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model[J]. Am J Transplant, 2006, 6(7): 1541-1550.
56	Pang XL, Wang ZG, Liu L, et al. Immature dendritic cells derived exosomes promotes immune tolerance by regulating T cell differentiation in renal transplantation[J]. Aging (Albany NY), 2019, 11(20): 8911-8924.
57	Yu X, Huang C, Song B, et al. CD4^＋ CD25^＋ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model [J]. Cell Immunol, 2013, 285(1-2): 62-68.
58	Ezzelarab MB, Raich-Regue D, Lu L, et al. Renal allograft survival in nonhuman primates infused with donor antigen-pulsed autologous regulatory dendritic cells[J]. Am J Transplant, 2017, 17(6): 1476-1489.
59	Aiello S, Rocchetta F, Longaretti L, et al. Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival[J]. Sci Rep, 2017, 7(1): 11518.
60	Kim S, Lee SA, Yoon H, et al. Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury [J]. Kidney Int, 2021, 100(3): 570-584.
61	Qian Z, Zhang X, Huang J, et al. ROS-responsive MSC-derived exosome mimetics carrying MHY1485 alleviate renal ischemia reperfusion injury through multiple mechanisms[J]. ACS Omega, 2024, 9(23): 24853-24863.
62	Lin J, Lv J, Yu S, et al. Transcript engineered extracellular vesicles alleviate alloreactive dynamics in renal transplantation[J]. Adv Sci (Weinh), 2022, 9(31): e2202633.
63	Tsai HI, Wu Y, Liu X, et al. Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection[J]. Adv Sci (Weinh), 2022, 9(3): e2102634.

[1]	Fan Wang, Hui Yu, Jiale Xie, Huanhuan Xu, Rui Ma, Aihaiti Yirixiati·, Ke Xu, Peng Xu. Role of fibroblast-like synoviocytes in pathogenesis of rheumatoid arthritis [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(02): 225-230.
[2]	Youhan Yang, Yinxian Wen, Liaobin Chen. Research progress of bacteriophage in treatment of periprosthetic joint infection [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(01): 125-130.
[3]	Branch of Organ Transplantation of Chinese Medical Association, Branch of Kidney Transplantation, China International Exchange and Promotive Association for Medical and Health Care. Clinical guideline for diagnosis and treatment of combined pancreas and kidney transplantation in China [J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(03): 129-147.
[4]	Lihong Shang, Zhihua Wang, Wenyan Zhang, Linru Zhu, Hua Zhou. Pre-transplantation endomucin antibody is independently associated with ABMR and affects the prognosis of renal allografts [J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(03): 165-170.
[5]	Ting Lu, Hao Chen, Xuejing Wang, Ruoyun Tan, Yuzhu Peng. Analysis of risk factors of metabolic syndrome after renal transplantation [J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(02): 98-103.
[6]	Mingxing Guo, Ye Xu, Wanyi Xu, Ying Zhao, Ranjia Liu, Chen Pan, Xiangli Cui. Analysis of immunosuppressive drugs used in outpatient patients after kidney transplantation at 105 hospitals in China from 2017 to 2022 [J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(02): 104-109.
[7]	Zhongwen Liu, Chang Liu, Yang Gao, Dong Liu, Shiqing Lin, Jianhua Yang, Fuyi Zhao. Correlation of urinary microRNA-326 with the prognosis of bladder cancer patients treated with radical cystectomy [J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(04): 386-391.
[8]	Hai Huang, Bisheng Cheng, Jian Huang. 2024 Annual Meeting of European Association of Urology: frontier exploration and future trends in prostate cancer research [J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(03): 202-207.
[9]	Yinan Zhang, Guozhen Zhu. Research progress on the transition from acute kidney injury to chronic kidney disease [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(02): 106-112.
[10]	Yan Wang, Haiqian Liang, Shanshan Guo. Research advances in role of inflammasome in traumatic brain injury [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(03): 177-181.
[11]	Qiuyue Zhang, Yu Cheng, Yutian Niu, Maozhi Tang, Keqin Zhang, Yi Zhang, Yanan Guo, Zeng Tu. Progress in understanding of correlation between kidney transplantation and human microecology [J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(02): 207-213.
[12]	Huiting Zhang, Ling Feng. In vitro fertilization-embryo transfer technology and preterm birth [J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2024, 13(02): 73-78.
[13]	Pingyue Zhao, Shangrong Fan. Diagnosis and treatment of hypercortisolism in pregnancy [J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2024, 13(01): 1-5.
[14]	Tong Zou, Qiang Yao. Diagnosis and treatment of pregnancy complicated with adrenal insufficiency [J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2024, 13(01): 6-12.
[15]	Li Wu, Jingjin Jiang. Inflammatory markers and frailty in the elderly [J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2024, 11(01): 5-10.

Please choose a citation manager

Content to export