Over the past15years,the number of organ donations and >transplants worldwide has shown a tortuous upward trend.In addition to continuously optimizing the prevention strategies for non-communicable diseases related to transplantation, countries are also striving to improve the efficiency of organ donation system, to expand the accessibility to organ transplantation services, and to achieve the sustainable development goals proposed by the United Nations. The present constitute a critical period for our endeavor to move toward national rejuvenation on all fronts through Chinese modernization. Adhering to the principle of "Put People and Their Lives First", and contributing to promotes Healthy China Initiative and raises socialist cultural-ethical standards, the Chinese organ donation program, with the participation of the Red Cross Society of China as a third party, has gradually embarked on a development path that contains the essence of Chinese modernization,highlighting the development path of complying with laws and regulations, adhering to spiritual guidance, firmly grasping institutional construction, emphasizing humanistic care, following ethical and moral principles, and emphasizing discipline construction. This article firstly reviews the history and current situation of organ donation and transplantation in the past 15 years at home and abroad, and to discusses the required internal and external environmental conditions for the development of organ donation and transplantation based on research data. Secondly, we summarize the characteristics of the current system construction and provide scientific advice for further optimizing the development strategies for organ donation in China.