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中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 313 -316. doi: 10.3877/cma.j.issn.1674-3903.2021.05.012

综述

心脏移植相关非甲状腺性病态综合征与甲状腺激素替代治疗
冯春蕾1, 黄洁1,()   
  1. 1. 100037 北京,中国医学科学院阜外医院 国家心血管病中心心力衰竭与移植病房
  • 收稿日期:2021-06-08 出版日期:2021-10-25
  • 通信作者: 黄洁

Nonthyroidal illness syndrome related to heart transplantation and thyroid hormone replacement therapy

Chunlei Feng1, Jie Huang1,()   

  1. 1. Department of Heart Failure and Transplantation, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China
  • Received:2021-06-08 Published:2021-10-25
  • Corresponding author: Jie Huang
引用本文:

冯春蕾, 黄洁. 心脏移植相关非甲状腺性病态综合征与甲状腺激素替代治疗[J/OL]. 中华移植杂志(电子版), 2021, 15(05): 313-316.

Chunlei Feng, Jie Huang. Nonthyroidal illness syndrome related to heart transplantation and thyroid hormone replacement therapy[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 313-316.

非甲状腺性病态综合征(NTIS)在接受心脏外科手术的患者中普遍存在,对重症患者的预后具有提示意义。其中大部分患者通常不需要进行甲状腺激素替代治疗,但心脏移植有其特殊性。心脏移植供者为脑死亡器官捐献者,脑死亡后体内甲状腺激素水平迅速降低。心脏移植受者多为终末期心力衰竭患者,术前即可能合并NTIS及其他甲状腺功能异常。心脏移植领域甲状腺激素替代治疗的相关研究尚不充分,结论仍有争议。本文对心脏移植相关NTIS和甲状腺激素替代治疗进行综述。

Nonthyroidal illness syndrome (NTIS) is common in patients undergoing cardiac surgery which is associated with the prognosis of critically ill patients, and thyroid hormone replacement therapy is considered unnecessary for most patients without cardiac dysfunction. But heart transplantation has its particularity. The heart transplantation donors are come from donation after brain death, the level of thyroid hormone of donors degrades rapidly after brain death. Most of the heart transplantation recipients are patients with end-stage heart failure, who are more likely to be presented with NTIS and other thyroid dysfunction before transplantation. There remains debate about the potential benefits of thyroid hormone supplementation when considered heart transplantation. Nonthyroidal illness syndrome related to heart transplantation and thyroid hormone replacement therapy is reviewed in this paper.

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