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中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 317 -320. doi: 10.3877/cma.j.issn.1674-3903.2021.05.013

综述

伊布替尼治疗慢性移植物抗宿主病的研究进展
刘恒1, 吴涛1,()   
  1. 1. 730050 兰州,联勤保障部队第九四〇医院血液科
  • 收稿日期:2021-02-10 出版日期:2021-10-25
  • 通信作者: 吴涛
  • 基金资助:
    甘肃省自然科学基金(20JR5RA595); 中央高校基本科研业务费项目(31920200011)

Research progress of ibrutinib in the treatment of chronic graft-versus-host disease

Heng Liu1, Tao Wu1,()   

  1. 1. Department of Hematology, the 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, China
  • Received:2021-02-10 Published:2021-10-25
  • Corresponding author: Tao Wu
引用本文:

刘恒, 吴涛. 伊布替尼治疗慢性移植物抗宿主病的研究进展[J]. 中华移植杂志(电子版), 2021, 15(05): 317-320.

Heng Liu, Tao Wu. Research progress of ibrutinib in the treatment of chronic graft-versus-host disease[J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 317-320.

异基因造血干细胞移植(allo-HSCT)为许多血液病患者带来了治愈的希望,但是移植物抗宿主病的发生限制了移植疗效。慢性移植物抗宿主病(cGVHD)是allo-HSCT后晚期非复发死亡的重要原因,并严重影响受者生存质量。伊布替尼在cGVHD的治疗中取得了较好效果,是首个被美国食品药品监督管理局批准的成人cGVHD二线治疗药物。本文就伊布替尼治疗cGVHD的研究进展进行综述。

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is potentially curative for a number of hematologic conditions, both malignant and nonmalignant. However, its success can be limited by the development of graft-versus-host disease. Chronic graft-versus-host disease (cGVHD) is a major cause for late non-relapse-related death in patients undergoing allo-HSCT, and seriously affects their quality of life. Resulting from its good effect on cGVHD, ibrutinib became the first FDA-approved therapy for the treatment of cGVHD in adult patients after failure of one or more lines of systemic therapy. In this review, we describe the progress of ibrutinib identified as potential cGVHD therapy.

表1 2016至2020年伊布替尼治疗cGVHD在研临床试验
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