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中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (01) : 55 -58. doi: 10.3877/cma.j.issn.1674-3903.2022.01.010

综述

肝癌肝移植桥接治疗进展
周辉年1, 李玉民1,()   
  1. 1. 730030 兰州大学第二医院普通外科
  • 收稿日期:2021-10-24 出版日期:2022-02-25
  • 通信作者: 李玉民
  • 基金资助:
    甘肃省2020年度重点人才项目(2020RCXM097); 兰州市人才创新创业项目(2018-RC-73)

Progress in bridging therapy of liver transplantation for hepatocellular carcinoma

Huinian Zhou1, Yumin Li1,()   

  1. 1. Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China
  • Received:2021-10-24 Published:2022-02-25
  • Corresponding author: Yumin Li
引用本文:

周辉年, 李玉民. 肝癌肝移植桥接治疗进展[J/OL]. 中华移植杂志(电子版), 2022, 16(01): 55-58.

Huinian Zhou, Yumin Li. Progress in bridging therapy of liver transplantation for hepatocellular carcinoma[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(01): 55-58.

肝移植是肝癌患者的最佳治疗方式之一,在给患者带来长期生存获益方面具有显著优势,但供肝不足导致部分等待肝移植的患者因肝癌病情进展最终退出等待者名单。桥接治疗能够控制部分肝癌患者病情进展,降低等待移植患者退出率。目前,临床常用的桥接治疗方法包括介入治疗、消融治疗和放疗。随着新的系统治疗和综合治疗策略在中晚期肝癌的降期治疗中取得了突出成果,这些方法能否用于桥接治疗也值得进一步探讨。

Liver transplantation is one of the best treatment options and can bring long-term survival benefits for patients with hepatocellular carcinoma. However, insufficient donor livers have led to some patients being withdrawn from the transplant waiting list. Bridging therapy can control the progression of some hepatocellular carcinoma and reduce the dropout rate of patients waiting for transplantation. Currently, commonly used bridging treatments include interventional therapy, ablation therapy, and radiotherapy. As new systemic and comprehensive strategies have achieved good results in downstaging of advanced hepatocellular carcinoma, whether these methods can be used for bridging therapy also deserves further investigation.

1
Llovet JM, Mas X, Aponte JJ, et al. Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation[J]. Gut, 2002, 50(1): 123-128.
2
Galuppo R, McCall A, Gedaly R. The role of bridging therapy in hepatocelhlar carcinoma[J]. Int J Hepatol, 2013:419302.
3
European Association for the Study of the Liver. EASL clinical practice guidelines: liver transplantation[J]. J Hepatol, 2016, 64(2): 433-485.
4
Thorat A, Lee CF, Wu TH, et al. Safety of transarterial chemoembolization as bridging therapy in HCC patients with hyperbilirubinemia on the waiting list for liver transplantation: a centre experience[J]. Hepatogastroenterology, 2012, 60(128): 2076-2079.
5
Pompili M, Francica G, Ponziani Fit, et al. Bridging and downstaging treatments for hepatocellular carcinoma in patients on the waiting list for liver transplantation[J]. World J Gastroenterol, 2013, 19(43): 7515-7530.
6
Yu CY, Ou HY, Weng CC, et al. Drug-eluting bead transarterial chemoembolization as bridge therapy for hepatocellular carcinoma before living-donor liver transplantation[J]. Transplant Proc, 201648(4):1045-1048.
7
Lai Q, Vitale A, Iesari S, et al. The intention-to-treat effect of bridging treatments in the setting of Milan criteria-in patients waiting for liver transplantation[J]. Liver Transpl, 2019, 25(7):1023-1033.
8
王浩, 高海军, 伊正甲, 等. 载药微球化疗栓塞治疗在肝癌肝移植术前应用的现状与进展[J]. 国际生物医学工程杂志2020, 43(3):255-259.
9
Lu DS, Yu NC, Raman SS, et al. Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation[J]. Hepatology, 2005, 41(5): 1130-1137.
10
Mazzaferro V, Battiston C, Perrone S, et al. Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study[J]. Ann Surg, 2004, 240(5): 900-909.
11
Cheung TT, Fan ST, Chan SC, et al. High-intensity focused ultrasound ablation: an effective bridging therapy for hepatocellular carcinoma patients[J]. WJG, 2013, 19(20): 3083-3092.
12
Chok KS, Cheung TT, Lo RC,et al. Pilot study of high-intensity focused ultrasound ablation as abridging therapy for hepatocellular carcinoma patients wait-listed for liver trailsplantation[J]. Liver Transpl, 2014, 20(8): 912-921.
13
汪国营. 肝癌肝移植新进展——2019年ILTS年会速递[J]. 器官移植2020, 11(1): 47-53.
14
Wong TC, Lee VH, Law AL, et al. Prospective study of stereotactic body radiation therapy for hepatocellular carcinoma on waitlist for liver transplant[J]. Hepatology, 2021, 74(5): 2580-2594.
15
邓斐文, 陈焕伟, 甄作均. 经颈静脉肝内门体分流术后肝移植单中心经验总结[J/CD]. 实用器官移植电子杂志2020, 8(4):261-266.
16
杨镇, 裘法祖. 门脉高压症外科治疗中应重视的几个问题[J]. 肝胆外科杂志2000, 8(1):1-2.
17
冷希圣. 肝移植时代如何看待门静脉高压症的断流手术[J]. 中国现代普通外科进展2007, 10(1):1-4.
18
Eilard MS, Andersson M, Naredi P, et al. A prospective clinical trial on sorafenib treatment of hepatocellular carcinoma before liver transplantation[J]. BMC Cancer, 2019, 19(1):568.
19
Maggiore U, Pascual J. The bad and the good news on cancer immunotherapy: implications for organ transplant recipients[J]. Adv Chronic Kidney Dis, 2016, 23(5):312-316.
20
Nordness MF, Hamel S, Godfrey CM, et al. Fatal hepatic necrosis after nivolumab as a bridge to liver transplant for HCC: are checkpoint inhibitors safe for the pretransplant patient?[J]. Am J Transplant, 2020, 20(3):879-883.
21
Chen GH, Wang GB, Huang F, et al. Pretransplant use of toripalimab for hepatocellular carcinoma resulting in fatal acute hepatic necrosis in the immediate postoperative period[J]. Transpl Immunol, 2021, 66:101386.
22
崔春晓, 杨柳晓, 王颖, 等.肝癌患者肝移植术前使用PD-1抑制剂对移植后排斥反应的影响[J]. 中国临床医学2020, 27(3):444-447.
23
Tabrizian P, Florman SS, Schwartz ME. PD-1 inhibitor as bridge therapy to liver transplantation?[J]. Am J Transplant, 2021, 21(5):1979-1980.
24
Díaz-Sánchez A, Matilla A, Núñez O, et al. Influence of treatment of hepatocellular carcinoma before liver transplantation on post transplant tumor recurrence and survival[J]. Gastroenterol Hepatol, 201033(3):155-164.
25
Clavien PA, Lesertel M, Bossuyt PM, et al. Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report[J]. Lancet Oncol, 2012, 13(1):e11-e22.
26
Cescon M, Cucchetti A, Ravaioli M, et al. Hepatocellular carcinoma locoregional therapies for patients in the waiting list. Impact on transplantability and recurrence rate[J]. J Hepatol, 2013, 58(3):609-618.
27
Heimbach JK, Kulik LM, Finn RS, et al. AASLD guidelines for the treatment of hepatocellular carcinoma[J]. Hepatology, 2018, 67(1):358-380.
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