Advances in the application of human umbilical cord mesenchymal stem cell in liver injury

doi:10.3877/cma.j.issn.1674-3903.2019.04.016

Abstract

Abstract:

End-stage liver disease caused by various acute and chronic liver injuries is a serious threat to human health. Taking effective measures to delay or even reverse the progress of liver injury has become a medical problem urgently to be solved. Human umbilical cord mesenchymal stem cell (hucMSC) is widely used in the study of liver injury because of their pluripotency, low immunogenicity, and non-inducing tumorigenesis after continuous passage in vitro. The results of animal experiments showed that after the injection of hucMSC into the injured liver, liver oxidative stress, inflammatory response and liver necrosis were alleviated, and the degree of liver damage was also significantly reduced. In clinical studies of patients with liver injury, hucMSC can not only slow down the inflammatory response, but also improve the immune status of the patients and prolong their postoperative survival. This article reviews the research progress of hucMSC in treating liver injury and delaying the progress of liver cirrhosis in recent years.

Key words: Human umbilical cord mesenchymal stem cell, Liver injury, Hepatic fibrosis

Wei Zhou, Qifa Ye. Advances in the application of human umbilical cord mesenchymal stem cell in liver injury[J]. Chinese Journal of Transplantation(Electronic Edition), 2019, 13(04): 323-326.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2019.04.016

https://zhyzzz.cma-cmc.com.cn/EN/Y2019/V13/I04/323

References 28

1	李宪哲，谢明颢，练磊. 间充质干细胞治疗炎症性肠病的应用及前景[J/CD]. 中华细胞与干细胞杂志(电子版), 2019, 9(4): 236-241.
2	Lee OK, Kuo TK, Chen WM, et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood[J]. Blood, 2004, 103(5): 1669-1675.
3	Si YL, Zhao YL, Hao HJ, et al. MSCs: biological characteristics, clinical applications and their outstanding concerns[J]. Ageing Res Rev, 2011, 10(1): 93-103.
4	Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells[J]. Blood, 2007, 110(10): 3499-3506.
5	Bongso A, Fong CY. The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton′s jelly of the human umbilical cord[J]. Stem Cell Rev, 2013, 9(2): 226-240.
6	Fan CG, Zhang QJ, Zhou JR. Therapeutic potentials of mesenchymal stem cells derived from human umbilical cord[J]. Stem Cell Rev, 2011, 7(1):195-207.
7	Vidal MA, Walker NJ, Napoli E, et al. Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue[J]. Stem Cells Dev, 2012, 21(2): 273-283.
8	Nekanti U, Rao VB, Bahirvani AG, et al. Long-term expansion and pluripotent marker array analysis of Wharton′s jelly-derived mesenchymal stem cells[J]. Stem Cells Dev, 2010, 19(1): 117-130.
9	Bruck R, Shirin H, Aeed H, et al. Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers[J]. J Hepatol, 2001, 35(4): 457-464.
10	Lee PH, Tu CT, Hsiao CC, et al. Antifibrotic activity of human placental amnion membrane-derived CD34^＋ mesenchymal stem/progenitor cell transplantation in mice with thioacetamide-induced liver injury[J]. Stem Cells Transl Med, 2016, 5(11): 1473-1484.
11	Mardpour S, Hassani SN, Mardpour S, et al. Extracellular vesicles derived from human embryonic stem cell-MSCs ameliorate cirrhosis in thioacetamide-induced chronic liver injury[J]. J Cell Physiol, 2017, 233(12): 9330-9344.
12	Lotfinia M, Kadivar M, Piryaei A, et al. Effect of secreted molecules of human embryonic stem cell-derived mesenchymal stem cells on acute hepatic failure model[J]. Stem Cells Dev, 2011, 25(24):1898-1908.
13	Yang Y, Ahn TJ, Moon C, et al. Protective effects of pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats[J]. Food Chem Toxicol, 2008, 46(1): 380-387.
14	Li T, Yan Y, Wang B, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis[J]. Stem Cells Dev, 2012, 22(6): 845-854.
15	Yan Y, Jiang W, Tan Y, et al. HucMSC exosome-derived GPX1 is required for the recovery of hepatic oxidant injury[J]. Mol Ther, 2017, 25(2): 465-479.
16	Yun JW, Ahn JH, Kwon E, et al. Human umbilical cord-derived mesenchymal stem cells in acute liver injury: hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution[J]. Regul Toxicol Pharmacol, 2016, 81:437-447.
17	Pushpavalli G, Veeramani C, Pugalendi KV. Influence of chrysin on hepatic marker enzymes and lipid profile against D-galactosamine-induced hepatotoxicity rats[J]. Food Chem Toxicol, 2010, 48(6): 1654-1659.
18	Ruan Q, Liu F, Gao Z, et al. The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats[J]. Mech Ageing Dev, 2013, 134(3-4): 89-97.
19	黄一鸣，王励，李进军，等. D-氨基半乳糖诱导的非人灵长类动物急性肝衰竭模型的建立[J]. 器官移植，2019, 10(1):55-59, 87.
20	Yan W, Li D, Chen T, et al. Umbilical cord MSCs reverse D-galactose-induced hepatic mitochondrial dysfunction via activation of Nrf2/HO-1 pathway[J]. Biol Pharm Bull, 2017, 40(8): 1174-1182.
21	顾世杰，陈云浩，赵辉，等. 不同途径移植人脐带间充质干细胞对大鼠肝脏缺血-再灌注损伤修复研究[J]. 器官移植，2017, 8(3):190-194.
22	周朝荣，吕海金，孙瑶，等. 人脐带间充质干细胞对小鼠肝缺血-再灌注损伤后肝内CD4^＋ T细胞的影响[J]. 器官移植，2018, 9(2): 103-109.
23	Kim HS, Ji HL, Roh KH, et al. Clinical trial of human umbilical cord blood-derived stem cells for the treatment of moderate-to-severe atopic dermatitis: phase Ⅰ/Ⅱa studies[J]. Stem Cells, 2017, 35(1): 248-255.
24	Shi M, Zhang Z, Xu R, et al. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients[J]. Stem Cells Transl Med, 2012, 1(10): 725-731.
25	陈榕，江涛，杨爱珍，等. 人脐带间充质干细胞应用于肝移植患者的观察[J]. 中国组织工程研究，2017, 21(17): 2665-2671.
26	段德，杨婧，杨晋辉，等. 人脐带间充质干细胞治疗肝硬化的研究进展[J]. 世界华人消化杂志，2016, 24(3): 362-367.
27	Sun Y, Shi H, Yin S, et al. Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-Cell destruction[J]. ACS Nano, 2018, 12(8):7613.
28	苏倩，尹华发，李家斌. 脐带间充质干细胞治疗终末期肝病的研究进展[J]. 国际流行病学传染病学杂志，2018, 45(3):204-207.

[1]	Jiansong Gao, Xiaoxiao Chen, Ting Feng, Jianfeng Bao, Shufang Wei, Lin Pan. Ultrasonic elastography based multiparameteric decision tree model for assessment of grade of liver fibrosis in patients with chronic hepatitis B [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(09): 923-929.
[2]	Tongtong Wang, Chunyu Zhu, Yingchu Liu, Guiju Gao. Current situation and mechanism of liver function injury in patients with acquired immunodeficiency syndrome combined with pneumocystis pneumonia treated by Trimethoprim sulfamethoxazole [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2023, 17(02): 79-83.
[3]	Xiaolin Jin, Zhibin Yang, Shuhua Zhan, Dan Zhu, Haiying He, Shuize Yin, Shiwu Ma. Influencing factor of liver dysfunction of inpatients of tuberculosis with initial treatment [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2020, 14(05): 394-400.
[4]	Jie Shu, Lifang Jiang, Ping Zhao. Clinical effect of alternate regional inflow into the liver for hepatectomy in patients with hepatocellular carcinoma and cirrhosis [J]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(01): 27-31.
[5]	Jiqiang Zhao, Jiquan Zhao, Feng Huo, Zhaohui He. Expression profiling analysis of microRNA in liver and serum of rat models from donation after cardiac death [J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 262-269.
[6]	Chaofeng Ding, Sheng Gao, Shusen Zheng. Prognostic factors of liver transplantation for patients with drug induced acute liver failure [J]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(04): 268-271.
[7]	Xi Lu, Tingting Yu, Zhigang Han. Association between CYP2D6 gene polymorphism and liver injury, rash, and diarrhea after targeted therapy inpatients with non-small cell lung cancer [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(06): 781-784.
[8]	Weijie Zeng, Yan Liao, Yue Hu, Juanyuan Hu, Guifang Zeng, Zeqin Fu, Shiduo Wu, Xiao Liang, Changfeng Xie, Muyun Liu. Comparison of immunosuppressive ability of human umbilical cord mesenchymal stem cells against T and B lymphocytes before and after cryopreservation [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(04): 200-206.
[9]	Wenli Xiu, Chenggang Mao, Chenyu Yang, Qian Dong. Mesenchymal stem cells modified with hepatocyte growth factor gene in the treatment of liver injury [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(06): 373-377.
[10]	Xiaoxiao Wang, Jinghui Hu, Jinyun Liu, Junfei Chen, Jingcheng Huang, Xianfu Luo. Value of contrast agent uptake related parameters of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging in evaluating the severity of drug induced liver injury in hepatobiliary phase [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(04): 204-209.
[11]	Jiyuan Ren, Zhimin Liu, Chunxing Li, Xuechun Xu, Ruoling Han. Evaluation of therapeutic effects for drug induced liver injury and viral hepatitis using quantitative ARFI technology [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(03): 264-267.
[12]	Xueying Lai, Bin Liu, Xueqin Hu, Haojun Chen. Therapeutic effect of magnesium isoglycyrrhizinate on liver injury induced by paclitaxel and its effect on serum IL-6, IL-10 and TNF-α [J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(11): 922-925.
[13]	Qing Tan, Jiangyun Wang, Qifeng Peng, Fang Liu, Yiping Gao, Shiqin Su, Bei Guo, Jianbo Zhao. Follow-up and risk factors analysis of liver function after transjugular intrahepatic portosystemic shunt [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2022, 10(01): 50-55.
[14]	Yan Liu, Shenjie Tang. Research progress on the correlation of intestinal flora with antitubercular agents and antitubercular agents-induced liver injury [J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 82-86.
[15]	Zhiqiang Liu, Xiangjie Dou, Bailu Liu, Xiaomeng Dong, Junyu Bao. Protective mechanism of ginkgo leaf extract and dipyridamole injection on hepatic ischemia reperfusion injury in rats [J]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(04): 259-265.

Please choose a citation manager

Content to export